Results 91 to 100 of about 284,848 (306)

Relationship Between Neurologic Symptoms and Signs and FMR1 Genotype in Premutation Carriers

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Objectives Fragile X‐associated Tremor/Ataxia Syndrome (FXTAS) is the most severe late‐onset condition caused by a premutation in the FMR1 gene, characterized by expanded CGG triplet repeats of 55–200. Clinical presentations of FXTAS, including gait ataxia, kinetic tremor, cognitive decline, and rare Parkinsonism, are linked to ...
Flora Tassone, Freddy Chafota, Miguel E. Rentería, Randi J. Hagerman, Ellery Santos, Anna Atkinson, Nicholas G. Martin, Elsdon Storey, Danuta Z. Loesch   +8 more
wiley   +1 more source

Patterns of Factors in the National Institute on Aging Health Disparities Research Framework Domains and Mild Cognitive Impairment Risk

AJPM Focus
Introduction: Alzheimer's disease and related dementias are public health and social care challenges. This study used the National Institute on Aging Health Disparities Research Framework to organize potential cognitive impairment risk factors.
Maria Vassilaki, MD, PhD, Jeremiah A. Aakre, MPH, Timothy G. Lesnick, MS, Walter K. Kremers, PhD, Jonathan Graff-Radford, MD, David S. Knopman, MD, Thomas H. Mosley, PhD, B. Gwen Windham, MD, MHS, Michael E. Griswold, PhD, Yonas E. Geda, MD, MSc, Val J. Lowe, MD, Clifford R. Jack, Jr., MD, Ronald C. Petersen, MD, PhD, Prashanthi Vemuri, PhD   +13 more
doaj   +1 more source

Effectiveness of rTMS on Working Memory and Inhibitory Impairments in Patients With Post‐Stroke Executive Deficits

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Considerable efforts have been dedicated to developing effective treatments for post‐stroke executive impairment (PSEI), among which repetitive transcranial magnetic stimulation (rTMS) has shown great potential. This study aimed to investigate the therapeutic effects of high‐frequency rTMS on working memory (WM) and response ...
Mengting Lao, Rongwei Du, Zhujun Wang, Yang Gao, Meiling Cheng, Xianglong Wang, Wen Wu   +6 more
wiley   +1 more source

Cortical sources of resting state EEG rhythms are sensitive to the progression of early stage Alzheimer's disease [PDF]

, 2013
Cortical sources of resting state electroencephalographic (EEG) rhythms are abnormal in subjects with Alzheimer's disease (AD). Here we tested the hypothesis that these sources are also sensitive to the progression of early stage AD over the course of ...
Nicola Marzano, Lizio, Roberta, Montella, Patrizia, F. Nobili, Giovanni B Frisoni, Vernieri, Fabrizio, De Salvo S, NOBILI, FLAVIO MARIANO, G. Tedeschi, Vernieri F, Nobili, Flavio, S. De Salvo, Frisoni GB, J. C. Richardson, De Salvo, Simona, P. M. Rossini, F. Vernieri, Babiloni C, Salvatore E, G. Rodriguez, Frisoni, Giovanni B., Paolo M. Rossini, A. Soricelli, Guido Rodriguez, Jill C. Richardson, G. B. Frisoni, Fabrizio Vernieri, C. Del Percio, Mundi C, Babiloni, Claudio, Salvatore, Elena, S. Marino, Del Percio C, Rossini P.M., Soricelli, Andrea, Marzano N, E. Salvatore, Elena Salvatore, Rossini, Paolo Maria, Lizio R, F. Ursini, Mundi, Ciro, Roberta Lizio, Silvia Marino, Tedeschi, Gioacchino, Richardson, Jill C., Montella P, R. Ferri, Flavio Nobili, Rodriguez G, Rossini PM, C. Mundi, Francesca Ursini, Filomena I.I. Cosentino, Gioacchino Tedeschi, Soricelli A, Tedeschi G, Raffaele Ferri, Cosentino, Filomena I. I., Ferri R, Richardson JC, F. I. I. Cosentino, Patrizia Montella, Marzano, Nicola, Del Percio, Claudio, Marino S, Claudio Del Percio, Rossini, Paolo M., Andrea Soricelli, P. Montella, Ferri, Raffaele, Marino, Silvia, Ursini, Francesca, Nobili F, N. Marzano, Cosentino, Filomena I.I., Rodriguez, Guido, Ursini F, Claudio Babiloni, Cosentino FI, Simona De Salvo, Ciro Mundi, Frisoni, Giovanni B   +82 more
core   +1 more source

[18F]Fluorodeprenyl‐D2 PET as a Tool to Monitor Disease Activity in GAD65‐Ab Autoimmune Encephalitis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate [18F]fluorodeprenyl‐D2 ([18F]F‐DED) positron‐emission tomography (PET) imaging as a biomarker of disease activity in autoimmune encephalitis (AIE) associated with glutamic acid decarboxylase 65 (GAD65) antibodies. Methods [18F]F‐DED PET was performed in 25 GAD65‐AIE patients and 8 controls using dynamic (0–60 min) and ...
Julia S. Dorneich, Jonathan A. Gernert, Hanna Zimmermann, Lisa Tagnin, Marianthi Zeinaki, Laura Sanzo, Letizia Vogler, Elisabeth Kaufmann, Justina Dargvainiene, Frank Leypoldt, Gérard N. Bischof, Robert Perneczky, Boris‐Stephan Rauchmann, Simon Lindner, Günter U. Höglinger, Rudolf A. Werner, Martin Kerschensteiner, Tania Kümpfel, Matthias Brendel, Franziska S. Thaler   +19 more
wiley   +1 more source

Validation of Addenbrooke’s cognitive examination III for detecting mild cognitive impairment and dementia in Japan

BMC Geriatrics, 2019
Background Early detection of mild cognitive impairment (MCI) and dementia is very important to begin appropriate treatment promptly and to prevent disease exacerbation.
Shintaro Takenoshita, Seishi Terada, Hidenori Yoshida, Megumi Yamaguchi, Mayumi Yabe, Nao Imai, Makiko Horiuchi, Tomoko Miki, Osamu Yokota, Norihito Yamada   +9 more
doaj   +1 more source

Longitudinal Assessment of Biomarkers in ALS: Discriminative Biomarkers for Disease Progression and Survival

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To assess the association and discriminative performance of serum biomarkers with clinical disease progression and survival in patients with amyotrophic lateral sclerosis (ALS). Methods This retrospective study, conducted at Houston Methodist Hospital, Houston, TX, used longitudinal serum samples collected between January 2018 and ...
David R. Beers, Yueh‐Yun Lin, Jason R. Thonhoff, Aaron D. Thome, Alireza Faridar, Weihua Zhao, Shixiang Wen, Stanley H. Appel   +7 more
wiley   +1 more source

Using machine learning for detection of Parkinson's disease and mild cognitive impairment.

PLoS ONE
BackgroundParkinson's disease is a movement disorder featuring motor symptoms and cognitive decline, which can manifest as mild cognitive impairment. The incidence of mild cognitive impairment increases with disease progression, and Parkinson's disease ...
Anthaea-Grace Patricia Dennis, Sarah L Martin, Robert Chen, Philip Gerretsen, Antonio P Strafella   +4 more
doaj   +1 more source

MCI, en dan? De toekomst van 'mild cognitive impairment'

Tijdschrift voor Gerontologie en Geriatrie, 2014
Bespreking: Belleville, S., Gauthier, S., Lepage, E., Kergoat, M.J. & Gilbert, B. (2014). Predicting decline in mild cognitive impairment: a prospective cognitive study. Neuropsychology, 28, 643–652.
Han F.A. Diesfeldt
doaj   +1 more source

Dementia and mild cognitive impairment in prisoners aged over 50 years in England and Wales: a mixed-methods study

Health Services and Delivery Research, 2020
Background: People aged ≥ 50 years constitute the fastest-growing group in the prison population of England and Wales. This population has complex health and social care needs.
Katrina Forsyth, Leanne Heathcote, Jane Senior, Baber Malik, Rachel Meacock, Katherine Perryman, Sue Tucker, Rachel Domone, Matthew Carr, Helen Hayes, Roger Webb, Laura Archer-Power, Alice Dawson, Sarah Leonard, David Challis, Stuart Ware, Richard Emsley, Caroline Sanders, Salman Karim, Seena Fazel, Adrian Hayes, Alistair Burns, Mary Piper, Jenny Shaw   +23 more
doaj   +1 more source