Results 81 to 90 of about 284,848 (306)

Microstate connectivity alterations in patients with early Alzheimer's disease [PDF]

, 2015
Electroencephalography (EEG) microstates and brain network are altered in patients with Alzheimer's disease (AD) and discussed as potential biomarkers for AD. Microstates correspond to defined states of brain activity, and their connectivity patterns may
Andreas Monsch (3564989), Christian Schindler (71594), Stephan RĂźegg (3564995), Michael Ehrensperger (3564992), Nina Benz, Ute Gschwandtner (811880), Monsch, Andreas U., Christian Schindler, Peter Fuhr, Stephan Rüegg, Hardmeier, Martin, Benz, Nina, Rüegg, Stephan, Martin Hardmeier (146865), Michael Ehrensperger, Gschwandtner, Ute, Florian Hatz, Ehrensperger, Michael, Fuhr, Peter, Martin Hardmeier, Andreas U. Monsch, Peter Fuhr (640430), Ute Gschwandtner, Schindler, Christian, Florian Hatz (640427), Nina Benz (3564983), Hatz, Florian   +26 more
core   +1 more source

Neuropathology of mild cognitive impairment

Rinsho Shinkeigaku, 2012
The concept of mild cognitive impairment (MCI) is clinical condition between normal cognition and dementia. Annual rate of conversion from MCI to dementia is estimated as 10-15%. It must be emphasized that all MCI will not be potential patients of dementing illness.
openaire   +3 more sources

Elevated Connectivity During Language Processing Is Associated With Cognitive Performance in SeLECTS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Self‐Limited Epilepsy with Centrotemporal Spikes (SeLECTS) is associated with language impairments despite seizures originating in the motor cortex, suggesting aberrant cross‐network interactions. Here we tested whether functional connectivity in SeLECTS during language tasks predicts language performance.
Wendy Qi, Katharine Lee, Kerry C. Nix, Miguel Menchaca, Xiwei Shé, Lorelei Santa Maria, Wei Wu, Zihuai He, Fiona M. Baumer   +8 more
wiley   +1 more source

Effect of emotional stimulus on response inhibition in people with mild cognitive impairment: an event-related potential study

Frontiers in Neuroscience
BackgroundA few studies are emerging to explore the issue of how aging promotes emotional response inhibition. However, there is a lack of empirical study concerning the impact of pathological cognitive impairment on emotional response inhibition.
Jing Wang, Cheng Li, Xiaohong Yu, Yue Zhao, Enfang Shan, Ying Xing, Xianwen Li   +6 more
doaj   +1 more source

Donepezil for mild cognitive impairment

Cochrane Database of Systematic Reviews, 2006
Problems with memory which do not meet the diagnostic criteria for dementia, usually called mild cognitive impairment (MCI), can be the first sign of an impending dementia, particularly Alzheimer's disease (AD). There is no consensus on a definition or diagnostic criteria for MCI, and MCI remains a vague term and those so described are a heterogeneous ...
Birks, Jacqueline, Flicker, Leon
openaire   +2 more sources

SPG4 and Dementia: Expanding the Clinical Spectrum

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Hereditary spastic paraplegia (HSP) is a group of disorders characterized by progressive spasticity and lower limb weakness, with mutations in SPG4/SPAST being the most common cause. Detailed studies and clinical and molecular comparisons across different populations are missing.
Emanuele Panza, Arun Meyyazhagan, Eliseo Picchi, Gustavo Ribas, Ingrid Faber, Ryosuke Miyamoto, Preethi Basavaraju, Paolo Eusebi, Haripriya Kuchi Bhotla, Mario Stasi, Fabrizio Gaudiello, Francesco Patti, Filippo Maria Santorelli, Marcondes Cavalcante França Jr, José Luiz Pedroso, Orlando Graziani Povoas Barsottini, Hélio Afonso Ghizoni Teive, Peter Henry St George‐Hyslop, Toshitaka Kawarai, Antonio Orlacchio   +19 more
wiley   +1 more source

Combining cognitive screening tests for the evaluation of mild cognitive impairment in the elderly

Clinics, 2009
OBJECTIVE: To determine the accuracy of the Mini-Mental State Examination combined with the Verbal Fluency Test and Clock Drawing Test for the identification of patients with mild cognitive impairment and Alzheimer's disease (AD).
Rodolfo B. Ladeira, Breno S. Diniz, Paula V. Nunes, Orestes V. Forlenza   +3 more
doaj   +1 more source

A Cognitive Electrophysiological Signature Differentiates Amnestic Mild Cognitive Impairment from Normal Aging [PDF]

, 2017
Background: Noninvasive and effective biomarkers for early detection of amnestic mild cognitive impairment (aMCI) before measurable changes in behavioral performance remain scarce.
Munro, Nancy B., Abner, Erin L., Kryscio, Richard J., Kryscio, Richard, Li, Juan, Jicha, Gregory A., Broster, Lucas S., Schmitt, Frederick A., Abner, Erin, Smith, Charles D., Jiang, Yang   +10 more
core   +1 more source

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

Molecular imaging of serotonin degeneration in mild cognitive impairment

Neurobiology of Disease, 2017
Neuropathological and neuroimaging studies have consistently demonstrated degeneration of monoamine systems, especially the serotonin system, in normal aging and Alzheimer's disease. The evidence for degeneration of the serotonin system in mild cognitive
Gwenn S. Smith, Frederick S. Barrett, Jin Hui Joo, Najlla Nassery, Alena Savonenko, Devin J. Sodums, Christopher M. Marano, Cynthia A. Munro, Jason Brandt, Michael A. Kraut, Yun Zhou, Dean F. Wong, Clifford I. Workman   +12 more
doaj   +1 more source