Results 81 to 90 of about 2,881,091 (302)

Functional Hubs in Mild Cognitive Impairment [PDF]

International Journal of Bifurcation and Chaos, 2015
We investigate how hubs of functional brain networks are modified as a result of mild cognitive impairment (MCI), a condition causing a slight but noticeable decline in cognitive abilities, which sometimes precedes the onset of Alzheimer's disease. We used magnetoencephalography (MEG) to investigate the functional brain networks of a group of patients
Adrián Navas, David Papo, Stefano Boccaletti, Francisco del Pozo, Ricardo Bajo, Fernando Maestú, Johann H. Martínez, Pablo Gil, Irene Sendiña-Nadal, Javier M. Buldú   +9 more
openaire   +3 more sources

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source

Perceived experiences of adults with mild cognitive impairment: a qualitative study

BMC Psychology
Introduction Increasing attention is being paid to preventing the progression of mild cognitive impairment and dementia. Today, there is a growing emphasis on listening to the “voice” of people with mild cognitive impairment to ensure patient-centered ...
Poursoleiman Leila, Rooddehghan Zahra, Bahramnezhad Fatemeh, Shafiee Sabet Mahdi, Dehghan Nayeri Nahid   +4 more
doaj   +1 more source

Threshold effects of insulin resistance on cognitive function in coronary heart disease: the non-linear diagnostic value of the triglyceride-glucose index

Frontiers in Cardiovascular Medicine
BackgroundInsulin resistance contributes to cognitive dysfunction in patients with coronary heart disease (CHD). We examined the dose-response relationship between the triglyceride-glucose (TyG) index and cognitive status in this population.MethodsWe ...
Shun Zhao, Yejing Zhao, Xiaohong Wu, Changjiang Li, Hongyu Peng   +4 more
doaj   +1 more source

Non-pharmacological interventions on cognitive functions in mild cognitive impairment and their efficacy in the light of meta-analyses and systematic reviews

Aktualności Neurologiczne, 2019
Recent decades have witnessed a growing interest in the possibilities of non-pharmacological modulation of cognitive functions in older patients using cognitive interventions, such as cognitive training, cognitive stimulation and cognitive rehabilitation.
Ludmiła Zając-Lamparska
doaj   +1 more source

Modern aspects of diagnosis and treatment of mild cognitive impairment

Российский журнал гериатрической медицины, 2020
The study of cognitive impairments (CI) began with a more severe form- dementia, which is usually the result of a long-running pathological process. It is preceded by non-demented cognitive disorders (including mild cognitive impairment syndrome — MCI ...
A. B. Lokshina
doaj   +1 more source

White Matter Microstructural Abnormalities in Neonatal Onset Genetic Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Recent evidence indicates that epilepsy is associated with abnormal white matter. If seizures alter white matter, then the impact upon network function, epileptogenesis, and cognition could be pronounced in neonates undergoing rapid developmental myelination. Neonates with epilepsy due to nonstructural genetic causes provide a unique
Amanda G. Sandoval Karamian, Tianjia Zhu, Hao Huang, Shavonne L. Massey, Mark P. Fitzgerald, Darshana Parikh, Arastoo Vossough, Ingo Helbig, Nicholas S. Abend   +8 more
wiley   +1 more source

Assessment of outcome in clinical trials in mild Alzheimer 19s disease: urgent time for a rethink? [PDF]

, 2013
Introduction: A major barrier for clinical trials in Alzheimer's disease is the lack of sensitive clinical endpoints for the early stages. Until recently, regulatory agencies have required demonstration of improvement in two disease domains, cognition ...
McGoldrick, S., Duffy, Fiona, McGoldrick, Susan, Reynish, Emma, Kelly, Fiona, Morrison, Y., Wilson, L., Bennett, Crispin, Wilson, J T Lindsay, Bennett, C., Morrison, Yvonne, Duffy, F., Reynish, E.   +12 more
core  

Preventing disability in older adults with mild cognitive impairment: A Strategy Training intervention study

Contemporary Clinical Trials Communications, 2019
Non-pharmacological interventions designed to change cognitive function in older adults with Mild Cognitive Impairment have shown mixed results. Few studied interventions directly address preclinical disability. Slowing changes in disability are critical
Juleen Rodakowski, Katlyn W. Golias, Charles F. Reynolds, III, Meryl A. Butters, Oscar L. Lopez, Mary Amanda Dew, Elizabeth R. Skidmore   +6 more
doaj   +1 more source

Cognitive and Neuroimaging Divergence Between Juvenile and Adult FUS Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by progressive motor neuron degeneration. Fused in sarcoma (FUS)‐associated juvenile ALS (jALS) represents a distinct and aggressive subgroup with rapid deterioration and poor prognosis.
Alexandra V. Jürs, Marcel Naumann, Annaliis Lehto, Hanna Schön, Jens Kurth, Johannes Prudlo, Andreas Hermann, Elisabeth Kasper   +7 more
wiley   +1 more source