Results 41 to 50 of about 168,085 (280)

Plasma-based S100B testing for management of traumatic brain injury in emergency setting

Practical Laboratory Medicine, 2021
Background: Serum biomarker S100B has been explored for its potential benefit to improve clinical decision-making in the management of patients suffering from traumatic brain injury (TBI), especially as a pre-head computed-tomography screening test for ...
Verena Haselmann, Christian Schamberger, Feodora Trifonova, Volker Ast, Matthias F. Froelich, Maximilian Strauß, Maximilian Kittel, Sabine Jaruschewski, David Eschmann, Michael Neumaier, Eva Neumaier-Probst   +10 more
doaj   +1 more source

modCHIMERA: A novel murine closed-head model of moderate traumatic brain injury [PDF]

, 2018
Traumatic brain injury is a major source of global disability and mortality. Preclinical TBI models are a crucial component of therapeutic investigation.
Bayly, P. V., Brody, D. L., Fanizzi, C., Gangolli, M., Kim, J. H., Kummer, T. T., Sauerbeck, A. D., Wellington, C. L.   +7 more
core   +2 more sources

Traumatic Microhemorrhages Are Not Synonymous With Axonal Injury

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Diffuse axonal injury (DAI) is caused by acceleration‐deceleration forces during trauma that shear white matter tracts. Susceptibility‐weighted MRI (SWI) identifies microbleeds that are considered the radiologic hallmark of DAI and are used in clinical prognostication.
Karinn Sytsma, Rhonda Mittenzwei, Heather Maioli, Amanda Kirkland, C. Dirk Keene, Ramon Diaz‐Arrastia, Christine Mac Donald, Chiara Maffei, Brian L. Edlow, Amber L. Nolan   +9 more
wiley   +1 more source

Mild Traumatic Brain Injury

Academic Radiology, 2010
Mild traumatic brain injuries (MTBI) are heterogeneous. This injury falls on a broad spectrum, from very mild neurometabolic changes in the brain with rapid recovery to permanent problems due to structural brain damage. It is incorrect to assume that MTBIs cannot cause permanent brain damage and it is incorrect to assume that MTBIs typically cause ...
Grant L. Iverson, Rael T. Lange
  +4 more sources

Links between traumatic brain injury and ballistic pressure waves originating in the thoracic cavity and extremities

, 2008
Identifying patients at risk of traumatic brain injury (TBI) is important because research suggests prophylactic treatments to reduce risk of long-term sequelae.
Alexander MP, Amy Courtney, Bruton C, Center for Disease Control and Prevention (CDC), Cernak I, Cernak I, Courtney M, Courtney M, Herrmann M, Krave U, Kushner DS, Kushner DS, Lowenstein DH, Margerison JH, Mayorga MA, Michael Courtney, Newgard K, Scott SG, Shaw NA, Stalnacke BM, Suneson A, Suneson A, Suneson A, Thompson HJ, Toth Z, Treib J, Trudeau DL, Vanderploeg RD, Vink R, Wang Q   +29 more
core   +1 more source

Long-term health outcomes after exposure to repeated concussion in elite level: rugby union players [PDF]

, 2016
Background: There is continuing concern about effects of concussion in athletes, including risk of the neurodegenerative disease chronic traumatic encephalopathy.
Hay, J., Maclean, L.M., McConnachie, A., McMillan, T.M., McSkimming, P., Stewart, W., Wainman-Lefley, J.   +6 more
core   +1 more source

CX3CL1 in Early Detection of Alzheimer's Disease: Plasma Dynamics Across Age and Disease Stages

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Backgrounds Alzheimer's disease (AD) is characterized by amyloid‐beta plaques, tau tangles, and neuroinflammation. C‐X3‐C motif chemokine ligand 1 (CX3CL1, also known as fractalkine), a neuroimmune chemokine implicated in AD pathogenesis, shows inconsistent alterations in plasma/serum across studies.
Ling Wang, Yujie Liu, Fei Li, Xuelin Li, Lanlan Li, Jie Zhang, Yali Xu   +6 more
wiley   +1 more source

Repeated Mild Traumatic Brain Injury

Cell Transplantation, 2017
Mild traumatic brain injury (mTBI) represents a significant public healthcare concern, accounting for the majority of all head injuries. While symptoms are generally transient, some patients go on to experience long-term cognitive impairments and ...
Brooke Fehily, Melinda Fitzgerald
doaj   +1 more source

Multidimensional Profiling of MRI‐Negative Temporal Lobe Epilepsy Uncovers Distinct Phenotypes

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Although hippocampal sclerosis (TLE‐HS) represents the most frequent cause of temporal lobe epilepsy (TLE), up to 30% of patients show no lesion on visual MRI inspection (TLE‐MRIneg). These cases pose diagnostic and therapeutic challenges and are underrepresented in surgical series.
Alice Ballerini, Alessia Casarini, Niccolò Biagioli, Laura Mirandola, Daniela Ballotta, Paul Summers, Simona Scolastico, Laura Madrassi, Maurilio Genovese, Marcella Malagoli, Gaetano Cantalupo, Giada Giovannini, Matteo Pugnaghi, Niccolò Orlandi, Laura Tassi, Valeria Cuccarini, Domenico Aquino, Elena Tartara, Fulvia Palesi, Giuseppe Didato, Paolo Vitali, the 3TLE Study Group, Roberta Di Giacomo, Fabio Doniselli, Federica Mazzi, Carlo Andrea Galimberti, Claudia A. M. Gandini Wheeler‐Kingshott, Stefano Meletti, Anna Elisabetta Vaudano   +28 more
wiley   +1 more source

Differential detection of impact site versus rotational site injury by magnetic resonance imaging and microglial morphology in an unrestrained mild closed head injury model. [PDF]

, 2016
Seventy-five percent of all traumatic brain injuries are mild and do not cause readily visible abnormalities on routine medical imaging making it difficult to predict which individuals will develop unwanted clinical sequelae. Microglia are brain-resident
Carson, Monica J, Donovan, Virgina, Grinberg, Yelena Y, Hernandez, Alfredo, Obenaus, Andre   +4 more
core