Results 171 to 180 of about 932 (190)

Interaction of mildronate with the mitochondrial carnitine/acylcarnitine transport protein

Journal of Biochemical and Molecular Toxicology, 2008
AbstractThe interaction of mildronate [3‐(2,2,2‐trimethylhydrazine) propionate] with the purified mitochondrial carnitine/acylcarnitine transporter reconstituted in liposomes has been studied. Mildronate, externally added to the proteoliposomes, strongly inhibited the carnitine/carnitine antiport catalyzed by the reconstituted transporter with an ...
Oppedisano Francesca, Fanello Delia, Calvani Menotti, INDIVERI, Cesare   +3 more
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Mildronate treatment improves functional recovery following middle cerebral artery occlusion in rats

Behavioural Brain Research, 2011
Mildronate (3-(2,2,2-trimethylhydrazinium) propionate) is an inhibitor of l-carnitine biosynthesis and an anti-ischemic drug. In the present study, we investigated the effects of mildronate in rats following focal cerebral ischemia. Male Wistar rats were subjected to transient occlusion of the middle cerebral artery (MCAO) for 90min, followed by the ...
Baiba, Svalbe, Liga, Zvejniece, Edijs, Vavers, Osvalds, Pugovics, Ruta, Muceniece, Edgars, Liepinsh, Maija, Dambrova   +6 more
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Mildronate enhances learning/memory and changes hippocampal protein expression in trained rats

Pharmacology Biochemistry and Behavior, 2013
Previously we demonstrated that mildronate [3-(2,2,2-trimethylhydrazinium) propionate dihydrate], a representative of the aza-butyrobetaine class of compounds, protects mitochondrial metabolism under conditions such as ischemia. Mildronate also acted as a neuroprotective agent in an azidothymidine-induced mouse model of neurotoxicity, as well as in a ...
Vija, Klusa, Ruta, Muceniece, Sergejs, Isajevs, Darja, Isajeva, Ulrika, Beitnere, Ilona, Mandrika, Jolanta, Pupure, Juris, Rumaks, Baiba, Jansone, Ivars, Kalvinsh, Harry V, Vinters   +10 more
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Neuroprotective effects of mildronate in a rat model of traumatic brain injury

Injury, 2019
Traumatic brain injury (TBI) is one of the most common preventable causes of mortality and morbidity. Inflammation, apoptosis, oxidative stress, and ischemia are some of the important pathophysiological mechanisms underlying neuronal loss after TBI. Mildronate is demonstrated to be beneficial in various experimental models of ischemic diseases via anti-
Dilan Demir, Pınar Kuru Bektaşoğlu, Türkan Koyuncuoğlu, Cansu Kandemir, Dilek Akakın, Meral Yüksel, Erhan Çelikoğlu, Berrak Ç. Yeğen, Bora Gürer   +8 more
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[Anti-atherosclerotic action of mildronate in experiment].

Patologicheskaia fiziologiia i eksperimental'naia terapiia, 2002
Mildronate is a new antiischemic drug which inhibits biosynthesis of carnitine from butyrobetaine. We studied antiatherosclerotic and antiinflammatory effects of mildronate in guinea-pigs, rats and rabbits. We found a hypolipidemic action of this substance in rats with triton WR-1339 hyperlipidemia. A protective antiatherosclerotic effect of mildronate
I V, Okunevich, V E, Ryzhenkov
openaire   +1 more source

Mildronate: Mechanisms of action and prospects for correction of pathologic states

Pharmaceutical Chemistry Journal, 1995
The energy metabolism of fatty acids (FA) is attributed to their intramitochondrial [?,-oxidation. FA with number of carbon atoms less than 12 penetrate into mitochondria by a camitine-independent pathway. Carnitine-y-trimethylamino[3-hydroxybutyrate is needed for the oxidation of long-chain FA [1, 2].
Zh. V. Shutenko, D. V. Meirena, T. I. Kagan, N. I. S'yakste, I. Ya. Kalvin'sh   +4 more
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[Absence of mutagenic and carcinogenic properties in Mildronate].

Voprosy onkologii, 1999
Mutagenic and carcinogenic properties of mildronate (3-[2.2.2.-trimethyl hydrazonium]-propionate) have been studied for its marked immuno-stimulating and anti-ischemic action. When dosage up to 1,000 mg/dish was used no reversal of base-pair substitution or frame shift in S.typhimurium was observed. In drosophila females treated with mildronate, mosaic
G A, Belitskiĭ, I Ia, Kalvinysh, V N, Anisimov, E M, Khovanova, E G, Ugvinenko, Iu D, Tolcheev   +5 more
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[Mildronate in the treatment of transitory ischemic attacks].

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 2013
An aim of the present study was to evaluate the treatment efficacy of the antioxidant mildronate in patients with transitory ischemic attacks. We studied the dynamics of clinical status, psychometric data and indices of free-radical lipid oxidation in 40 patients. The improvement in the subjective state, memory and attention was seen in 24 patients.
M Iu, Maksimova, T N, Fedorova
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MILDRONATE

Drugs of the Future, 1989
J. Prous, J. Castañer
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[Efficacy and safety of mildronate in emergency medical care].

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 2014
Detailed clinical data about patients who used emergency services during 2011 are presented. The main attention is focused on the state of patients with acute and chronic brain ischemia before and after treatment with mildronate. Mean age of patients with ischemic stroke and chronic brain ischemia was 63.4 and 57.7 years, respectively.
N M, Nevzorov, Yu N, Markevich
openaire   +1 more source