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Mildronate Cardioprotective Action through Carnitine-Lowering Effect
Trends in Cardiovascular Medicine, 2002Mildronate [3-(2,2,2-trimethylhydrazinium)propionate dihydrate] ameliorates cardiac function during ischemia by modulating myocardial energy metabolism. Biochemical and pharmacological evidence supports the hypothesis that the mechanism of action of mildronate is based on its regulatory effect on carnitine concentration, whereby mildronate treatment ...
Edgars Liepinsh, Maija Dambrova
exaly +3 more sources
Neuroprotective properties of mildronate, a mitochondria-targeted small molecule
Neuroscience Letters, 2010Mildronate, a representative of the aza-butyrobetaine class of drugs with proven cardioprotective efficacy, was recently found to prevent dysfunction of complex I in rat liver mitochondria. The present study demonstrates that mildronate also acts as a neuroprotective agent.
Jolanta Pupure +2 more
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Interaction of mildronate with the mitochondrial carnitine/acylcarnitine transport protein
Journal of Biochemical and Molecular Toxicology, 2008AbstractThe interaction of mildronate [3‐(2,2,2‐trimethylhydrazine) propionate] with the purified mitochondrial carnitine/acylcarnitine transporter reconstituted in liposomes has been studied. Mildronate, externally added to the proteoliposomes, strongly inhibited the carnitine/carnitine antiport catalyzed by the reconstituted transporter with an ...
Francesca Oppedisano, Cesare Indiveri
exaly +3 more sources
Mildronate treatment improves functional recovery following middle cerebral artery occlusion in rats
Behavioural Brain Research, 2011Mildronate (3-(2,2,2-trimethylhydrazinium) propionate) is an inhibitor of l-carnitine biosynthesis and an anti-ischemic drug. In the present study, we investigated the effects of mildronate in rats following focal cerebral ischemia. Male Wistar rats were subjected to transient occlusion of the middle cerebral artery (MCAO) for 90min, followed by the ...
Liga Zvejniece +2 more
exaly +3 more sources
Mildronate enhances learning/memory and changes hippocampal protein expression in trained rats
Pharmacology Biochemistry and Behavior, 2013Previously we demonstrated that mildronate [3-(2,2,2-trimethylhydrazinium) propionate dihydrate], a representative of the aza-butyrobetaine class of compounds, protects mitochondrial metabolism under conditions such as ischemia. Mildronate also acted as a neuroprotective agent in an azidothymidine-induced mouse model of neurotoxicity, as well as in a ...
Vija Kluša +2 more
exaly +3 more sources
Protective effects of mildronate in an experimental model of type 2 diabetes in Goto‐Kakizaki rats [PDF]
British Journal of Pharmacology, 2009 Background and purpose: Mildronate [3-(2,2,2-trimethylhydrazinium) propionate] is an anti-ischaemic drug whose mechanism of action is based on its inhibition of L-carnitine biosynthesis and uptake.
Edgars Liepinsh +2 more
exaly +3 more sources
Mildronate exerts acute anticonvulsant and antihypnotic effects
Behavioural Pharmacology, 2010The effects of mildronate [3-(2,2,2-trimethylhydrazinium) propionate], an inhibitor of L-carnitine biosynthesis and an anti-ischaemic drug, were examined in various in-vivo conditions to investigate the neuropharmacological profile after acute administration.
Liga, Zvejniece +5 more
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The use of the drug mildronate in obstetrics
Journal of obstetrics and women's diseases, 2021The report contains data on positive influence of mildronatum infusion (10% NaCl) on uterine-placental and fetoplacental circulation in women with chronic placental insufficiency in the third trimester of pregnancy.
N. G. Pavlova +2 more
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Microencapsulation of mildronate in biodegradable and non-biodegradable polymers
Journal of Microencapsulation, 2013The extremely high hygroscopicity (solubility in water ≥2 g/ml) of the pharmaceutical preparation mildronate defines specific requirements to both packaging material and storage conditions. To overcome the above mentioned inconveniences, microencapsulated form of mildronate was developed using polystyrene (PS) and poly (lactic acid) (PLA) as watertight
Dagnija, Loca +6 more
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EFFECTS OF THE DRUG MILDRONATE
2023Mildronate (3-(2,2,2-trimethylhydrazine) propionate; THP; MET-88; meldonium, quaterine) is an anti-ischemic drug developed in the Latvian Institute of Organic Synthesis. Mildronate was designed as a promising inhibitor of carnitine biosynthesis aimed to prevent accumulation of cytotoxic intermediate products of fatty acid beta- oxidation in ischemic ...
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