Results 141 to 150 of about 624 (180)

The use of the drug mildronate in obstetrics

Journal of obstetrics and women's diseases, 2021
The report contains data on positive influence of mildronatum infusion (10% NaCl) on uterine-placental and fetoplacental circulation in women with chronic placental insufficiency in the third trimester of pregnancy.
N. G. Pavlova, E. I. Krivtsova, N. N. Konstantinova   +2 more
openaire   +1 more source

Neuroprotective properties of mildronate, a mitochondria-targeted small molecule

Neuroscience Letters, 2010
Mildronate, a representative of the aza-butyrobetaine class of drugs with proven cardioprotective efficacy, was recently found to prevent dysfunction of complex I in rat liver mitochondria. The present study demonstrates that mildronate also acts as a neuroprotective agent.
Šimons Svirskis, Sergejs Isajevs, Jolanta Pupure   +2 more
exaly   +3 more sources

Interaction of mildronate with the mitochondrial carnitine/acylcarnitine transport protein

Journal of Biochemical and Molecular Toxicology, 2008
AbstractThe interaction of mildronate [3‐(2,2,2‐trimethylhydrazine) propionate] with the purified mitochondrial carnitine/acylcarnitine transporter reconstituted in liposomes has been studied. Mildronate, externally added to the proteoliposomes, strongly inhibited the carnitine/carnitine antiport catalyzed by the reconstituted transporter with an ...
Cesare Indiveri, Francesca Oppedisano, Menotti Calvani   +2 more
exaly   +3 more sources

Inhibition of carnitine acetyltransferase by mildronate, a regulator of energy metabolism

Journal of Enzyme Inhibition and Medicinal Chemistry, 2009
Carnitine acetyltransferase (CrAT; EC 2.3.1.7) catalyzes the reversible transfer of acetyl groups between acetyl-coenzyme A (acetyl-CoA) and L-carnitine; it also regulates the cellular pool of CoA and the availability of activated acetyl groups. In this study, biochemical measurements, saturation transfer difference (STD) nuclear magnetic resonance ...
Janis Kuka, Maija Dambrova, Edgars Liepinsh   +2 more
exaly   +3 more sources

Mildronate exerts acute anticonvulsant and antihypnotic effects

Behavioural Pharmacology, 2010
The effects of mildronate [3-(2,2,2-trimethylhydrazinium) propionate], an inhibitor of L-carnitine biosynthesis and an anti-ischaemic drug, were examined in various in-vivo conditions to investigate the neuropharmacological profile after acute administration.
Liga, Zvejniece, Baiba, Svalbe, Marina, Makrecka, Edgars, Liepinsh, Ivars, Kalvinsh, Maija, Dambrova   +5 more
openaire   +2 more sources

A Dose-Dependent Improvement in Exercise Tolerance in Patients With Stable Angina Treated With Mildronate: A Clinical Trial “MILSS I”

Medicina (Lithuania), 2011
Objective. To assess the efficacy of various doses of Mildronate in combination with standard therapy for the exercise tolerance of patients with stable angina pectoris.
null null, Vilnis Dzerve
exaly   +3 more sources

Microencapsulation of mildronate in biodegradable and non-biodegradable polymers

Journal of Microencapsulation, 2013
The extremely high hygroscopicity (solubility in water ≥2 g/ml) of the pharmaceutical preparation mildronate defines specific requirements to both packaging material and storage conditions. To overcome the above mentioned inconveniences, microencapsulated form of mildronate was developed using polystyrene (PS) and poly (lactic acid) (PLA) as watertight
Dagnija, Loca, Eduards, Sevostjanovs, Marina, Makrecka, Olga, Zharkova-Malkova, Liga, Berzina-Cimdina, Velta, Tupureina, Marina, Sokolova   +6 more
openaire   +2 more sources

Mildronate Cardioprotective Action through Carnitine-Lowering Effect

Trends in Cardiovascular Medicine, 2002
Mildronate [3-(2,2,2-trimethylhydrazinium)propionate dihydrate] ameliorates cardiac function during ischemia by modulating myocardial energy metabolism. Biochemical and pharmacological evidence supports the hypothesis that the mechanism of action of mildronate is based on its regulatory effect on carnitine concentration, whereby mildronate treatment ...
Maija, Dambrova, Edgars, Liepinsh, Ivars, Kalvinsh   +2 more
openaire   +4 more sources

HPLC analysis of mildronate and its analogues in plasma

Journal of Pharmaceutical and Biomedical Analysis, 1993
O, Sahartova, V, Shatz, I, Kalvins
exaly   +3 more sources

Single- and Multiple-dose Pharmacokinetic, Safety and Tolerability Study of Mildronate Injection in Healthy Chinese Subjects Pharmacokinetic of Mildronate Injection

Drug Research, 2015
Mildronate is an agent for cardioprotection and neuroprotection. This study aimed to evaluate the pharmacokinetic (PK) profiles, safety and tolerability of mildronate injection after single escalating doses and multiple doses in healthy Chinese subjects. We performed a randomized, open-label, single- and multiple-dose phase I trial including 3 doses of
Z, Zhao, J, Chen, W, Peng, X, Wang, Z, Chen, H, Tang, Y, Liang, Z, Ma, J, Chen, X, Chen, G, Zhong, M, Huang   +11 more
openaire   +2 more sources