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Neuroprotective properties of mildronate, a mitochondria-targeted small molecule
Neuroscience Letters, 2010Mildronate, a representative of the aza-butyrobetaine class of drugs with proven cardioprotective efficacy, was recently found to prevent dysfunction of complex I in rat liver mitochondria. The present study demonstrates that mildronate also acts as a neuroprotective agent.
Simons Svirskis +2 more
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Interaction of mildronate with the mitochondrial carnitine/acylcarnitine transport protein
Journal of Biochemical and Molecular Toxicology, 2008AbstractThe interaction of mildronate [3‐(2,2,2‐trimethylhydrazine) propionate] with the purified mitochondrial carnitine/acylcarnitine transporter reconstituted in liposomes has been studied. Mildronate, externally added to the proteoliposomes, strongly inhibited the carnitine/carnitine antiport catalyzed by the reconstituted transporter with an ...
Cesare Indiveri, Francesca Oppedisano
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Neuroprotective effects of mildronate in a rat model of traumatic brain injury
Injury, 2019Traumatic brain injury (TBI) is one of the most common preventable causes of mortality and morbidity. Inflammation, apoptosis, oxidative stress, and ischemia are some of the important pathophysiological mechanisms underlying neuronal loss after TBI. Mildronate is demonstrated to be beneficial in various experimental models of ischemic diseases via anti-
Pinar Kuru Bektasoglu +2 more
exaly +4 more sources
HPLC analysis of mildronate and its analogues in plasma
Journal of Pharmaceutical and Biomedical Analysis, 1993O, Sahartova, V, Shatz, I, Kalvins
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The use of the drug mildronate in obstetrics
Journal of obstetrics and women's diseases, 2021The report contains data on positive influence of mildronatum infusion (10% NaCl) on uterine-placental and fetoplacental circulation in women with chronic placental insufficiency in the third trimester of pregnancy.
N. G. Pavlova +2 more
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Microencapsulation of mildronate in biodegradable and non-biodegradable polymers
Journal of Microencapsulation, 2013The extremely high hygroscopicity (solubility in water ≥2 g/ml) of the pharmaceutical preparation mildronate defines specific requirements to both packaging material and storage conditions. To overcome the above mentioned inconveniences, microencapsulated form of mildronate was developed using polystyrene (PS) and poly (lactic acid) (PLA) as watertight
Dagnija, Loca +6 more
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