Results 171 to 180 of about 961 (200)

Mildronate Ameliorates Kidney Function and Reduces Inflammation in SCD Mice

Blood, 2023
INTRODUCTION:Sickle cell disease (SCD) is a genetic hemoglobin disorder characterized by hemolytic anemia, vaso-occlusive crisis and inflammation that affects organs such as the kidney, liver, brain, spleen, and heart. SCD is driven by a mutation in the β-globin gene that causes sickling of red blood cells (RBCs).
Asrar Ahmad, Clemilson Berto-Junior, Papa Hoyeck, Namita Kumari, Marina Jerebtsova, Sergei Nekhai   +5 more
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Single- and Multiple-dose Pharmacokinetic, Safety and Tolerability Study of Mildronate Injection in Healthy Chinese Subjects Pharmacokinetic of Mildronate Injection

Drug Research, 2015
Mildronate is an agent for cardioprotection and neuroprotection. This study aimed to evaluate the pharmacokinetic (PK) profiles, safety and tolerability of mildronate injection after single escalating doses and multiple doses in healthy Chinese subjects. We performed a randomized, open-label, single- and multiple-dose phase I trial including 3 doses of
Z, Zhao, J, Chen, W, Peng, X, Wang, Z, Chen, H, Tang, Y, Liang, Z, Ma, J, Chen, X, Chen, G, Zhong, M, Huang   +11 more
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Neuroprotective effects of mildronate in a rat model of traumatic brain injury

Injury, 2019
Traumatic brain injury (TBI) is one of the most common preventable causes of mortality and morbidity. Inflammation, apoptosis, oxidative stress, and ischemia are some of the important pathophysiological mechanisms underlying neuronal loss after TBI. Mildronate is demonstrated to be beneficial in various experimental models of ischemic diseases via anti-
Dilan Demir, Pınar Kuru Bektaşoğlu, Türkan Koyuncuoğlu, Cansu Kandemir, Dilek Akakın, Meral Yüksel, Erhan Çelikoğlu, Berrak Ç. Yeğen, Bora Gürer   +8 more
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[Anti-atherosclerotic action of mildronate in experiment].

Patologicheskaia fiziologiia i eksperimental'naia terapiia, 2002
Mildronate is a new antiischemic drug which inhibits biosynthesis of carnitine from butyrobetaine. We studied antiatherosclerotic and antiinflammatory effects of mildronate in guinea-pigs, rats and rabbits. We found a hypolipidemic action of this substance in rats with triton WR-1339 hyperlipidemia. A protective antiatherosclerotic effect of mildronate
I V, Okunevich, V E, Ryzhenkov
openaire   +1 more source

Mildronate: Mechanisms of action and prospects for correction of pathologic states

Pharmaceutical Chemistry Journal, 1995
The energy metabolism of fatty acids (FA) is attributed to their intramitochondrial [?,-oxidation. FA with number of carbon atoms less than 12 penetrate into mitochondria by a camitine-independent pathway. Carnitine-y-trimethylamino[3-hydroxybutyrate is needed for the oxidation of long-chain FA [1, 2].
Zh. V. Shutenko, D. V. Meirena, T. I. Kagan, N. I. S'yakste, I. Ya. Kalvin'sh   +4 more
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[Absence of mutagenic and carcinogenic properties in Mildronate].

Voprosy onkologii, 1999
Mutagenic and carcinogenic properties of mildronate (3-[2.2.2.-trimethyl hydrazonium]-propionate) have been studied for its marked immuno-stimulating and anti-ischemic action. When dosage up to 1,000 mg/dish was used no reversal of base-pair substitution or frame shift in S.typhimurium was observed. In drosophila females treated with mildronate, mosaic
G A, Belitskiĭ, I Ia, Kalvinysh, V N, Anisimov, E M, Khovanova, E G, Ugvinenko, Iu D, Tolcheev   +5 more
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[Mildronate in the treatment of transitory ischemic attacks].

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 2013
An aim of the present study was to evaluate the treatment efficacy of the antioxidant mildronate in patients with transitory ischemic attacks. We studied the dynamics of clinical status, psychometric data and indices of free-radical lipid oxidation in 40 patients. The improvement in the subjective state, memory and attention was seen in 24 patients.
M Iu, Maksimova, T N, Fedorova
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MILDRONATE

Drugs of the Future, 1989
J. Prous, J. Castañer
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[Efficacy and safety of mildronate in emergency medical care].

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 2014
Detailed clinical data about patients who used emergency services during 2011 are presented. The main attention is focused on the state of patients with acute and chronic brain ischemia before and after treatment with mildronate. Mean age of patients with ischemic stroke and chronic brain ischemia was 63.4 and 57.7 years, respectively.
N M, Nevzorov, Yu N, Markevich
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Mildronate in ophthalmic disorders

2013
Viene descritta una composizione utile per il trattamento di patologie oculari su base ...
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