Results 51 to 60 of about 1,198,612 (297)

Cancer cell death induced by the NAD antimetabolite Vacor discloses the antitumor potential of SARM1

FEBS Letters, EarlyView.
Vacor, a compound converted into the toxic metabolite Vacor adenine dinucleotide (VAD) by the nicotinamide salvage pathway enzymes NAMPT and NMNAT2, exhibits antitumor activity by inducing rapid and complete NAD depletion. We report that Vacor toxicity is limited to cell lines expressing high levels of SARM1, a NAD glycohydrolase.
Giuseppe Ranieri, Andrea Lapucci, Giuseppe Orsomando, Nadia Raffaelli, Alberto Chiarugi, Daniela Buonvicino   +5 more
wiley   +1 more source

Receiving screened donor human milk as part of a community‐based lactation support programme reduces parental symptoms of anxiety and depression

Maternal and Child Nutrition
Infant feeding decisions and maternal mental health are closely tied. Donor human milk (DHM) protects premature infant health and development and can reduce hospital stays.
Amy Brown, Sam Griffin, Gillian Weaver, Natalie Shenker   +3 more
doaj   +1 more source

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer

Molecular Oncology, EarlyView.
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley   +1 more source

Sequencing the transcriptome of milk production: milk trumps mammary tissue [PDF]

, 2013
Background: Studies of normal human mammary gland development and function have mostly relied on cell culture, limited surgical specimens, and rodent models.
Barry, Peter A, German, J Bruce, Hartono, Stella R, Hinde, Katie, Hovey, Russell C, Islas-Trejo, Alma, Korf, Ian, Lee, Joyce WS, Lemay, Danielle G, Medrano, Juan F, Schmidt, Kimberli A, Silva, Pedro Ivo, Smilowitz, Jennifer T, Ventimiglia, Frank   +13 more
core   +2 more sources

Cytomegalovirus infection is common in prostate cancer and antiviral therapies inhibit progression in disease models

Molecular Oncology, EarlyView.
Human cytomegalovirus infection is common in normal prostate epithelium, prostate tumor tissue, and prostate cancer cell lines. CMV promotes cell survival, proliferation, and androgen receptor signaling. Anti‐CMV pharmaceutical compounds in clinical use inhibited cell expansion in prostate cancer models in vitro and in vivo, motivating investigation ...
Johanna Classon, Moa Stenudd, Margherita Zamboni, Kanar Alkass, Carl‐Johan Eriksson, Lars Pedersen, Alrik Schörling, Anna Thoss, Anders Bergh, Pernilla Wikström, Hans‐Olov Adami, Henrik Toft Sørensen, Henrik Druid, Jonas Frisén   +13 more
wiley   +1 more source

Persistence of Supplemented Bifidobacterium longum subsp. infantis EVC001 in Breastfed Infants. [PDF]

, 2017
Attempts to alter intestinal dysbiosis via administration of probiotics have consistently shown that colonization with the administered microbes is transient. This study sought to determine whether provision of an initial course of Bifidobacterium longum
Andra A. Hutton, Bethany M. Henrick, Carlito B. Lebrilla, Claire A. Shaw, Daniela Barile, David A. Mills, Gege Xu, Giorgio Casaburi, J. Bruce German, Jasmine C. C. Davis, Jennifer T. Smilowitz, Lindsey N. Contreras, Mark A. Underwood, Michelle C. Palumbo, Rosa Krajmalnik-Brown, Samara L. Freeman, Steven A. Frese   +16 more
core   +2 more sources

Targeting of PTP4A3 overexpression sensitises HGSOC cells towards chemotherapeutic drugs

Molecular Oncology, EarlyView.
In HGSOC with normal KRAS expression, high PTP4A3 expression regulates autophagy activation. Conversely, in HGSOC with high KRAS expression, KRAS dictates autophagy control, and PTP4A3 is not required. When high PTP4A3 expression is inhibited, HGSOC cells are preferentially sensitised towards DNA‐damaging agents.
Ana López‐Garza, David James, Emma Creagh, James T. Murray   +3 more
wiley   +1 more source

Cerebral low-molecular metabolites influenced by intestinal microbiota: a pilot study

Frontiers in Systems Neuroscience, 2013
Recent studies suggest that intestinal microbiota influences gut-brain communication. In this study, we aimed to clarify the influence of intestinal microbiota on cerebral metabolism. We analyzed the cerebral metabolome of germ-free (GF) mice and ex-germ-
Mitsuharu eMatsumoto, Ryoko eKibe, Takushi eOoga, Yuji eAiba, Emiko eSawaki, Yasuhiro eKoga, Yoshimi eBenno   +6 more
doaj   +1 more source

Quantification of phospholipids and glycerides in human milk using ultra-performance liquid chromatography with quadrupole-time-of-flight mass spectrometry

Frontiers in Chemistry, 2023
Human milk lipids, which are an important source of energy and affect growth and development of infants, require a comprehensive method for its qualitative and quantitative analysis.
Yan Liu, Yan Liu, Weicang Qiao, Weicang Qiao, Yanpin Liu, Yanpin Liu, Junying Zhao, Junying Zhao, Qian Liu, Qian Liu, Kai Yang, Kai Yang, Minghui Zhang, Minghui Zhang, Yaling Wang, Yaling Wang, Yan Liu, Yan Liu, Lijun Chen, Lijun Chen   +19 more
doaj   +1 more source