Results 181 to 190 of about 6,179,746 (234)

Single‐Cell Mapping Identifies Aging‐Associated Neutrophil Remodeling Across Multiple Organs

Aging Cell, Volume 25, Issue 10, October 2026.
Single‐cell transcriptomic profiling across multiple organs identifies aging reshapes neutrophil differentiation from the bone marrow to peripheral tissues. Computation analysis identifies an age‐enriched Neu06‐IL6 neutrophil state and predicts IL‐6 as one of a candidate regulator for neutrophil remodeling.
Yuman Wang, Teding Chang, Yangguang Fu, Guangyu Liang, Huicheng Liu, Le Zhang, Jinhua Yan, Man Liu, Anding Liu, Cuntai Zhang   +9 more
wiley   +1 more source

Inflammation-Associated Changes in Bioactive Proteins and Peptides of Bovine Milk: Evidence from Mastitis, Lameness, and Metabolic Disorders-A Review. [PDF]

Molecules
Kovács L, Sándorová L, Pajor F.
europepmc   +1 more source

Prodh2‐Mediated Mitochondrial Stress Drives TNF‐α‐Induced Myoblast Dysfunction and Sarcopenia in COPD

Aging Cell, Volume 25, Issue 10, October 2026.
TNF‐α upregulates Prodh2 via p53 in COPD myoblasts, driving mitochondrial ROS–induced cGAS/STING activation and myoblast dysfunction. This metabolic‐immune pathway underlies sarcopenia, positioning Prodh2 as a therapeutic target for COPD‐associated muscle wasting. ABSTRACT Sarcopenia in chronic obstructive pulmonary disease (COPD) is driven by elevated
Gang Chen, Zhitao Shangguan, Jingjing Gong, Dalu Cheng, Penghong Chen, Jiandong Li, Qiong Lin   +6 more
wiley   +1 more source

Betaine Promotes Milk Protein Synthesis via Alleviating Oxidative Stress Caused by NEFA in Mammary Epithelial Cells of Dairy Cows. [PDF]

Vet Med Sci
Yan W, Sun X, Shi H, Li Z, Li W, Gao X, Dong J.   +6 more
europepmc   +1 more source

Repeated Moderate and Severe Heat Exposure Has Divergent Effects on Skeletal Muscle Mitochondrial, Proteostatic and Neuromuscular Outcomes in Mice

Acta Physiologica, Volume 242, Issue 10, October 2026.
ABSTRACT Aim Repeated heat exposure may promote adaptive remodeling or cumulative tissue burden depending on thermal dose, but its graded molecular and functional consequences during recovery remain unclear. We examined whether repeated moderate (39°C) and severe (41°C) whole‐body hyperthermia produce distinct skeletal muscle trajectories involving ...
Cansu Yakin, Cihan Suleyman Erdogan, Fatma Ozge Tuncel, Yunus Kosif, Bayram Yilmaz   +4 more
wiley   +1 more source

Is Milk Thistle a Cardioprotective Ally or a Thrombotic Threat? [PDF]

JACC Case Rep
Lindner E, Alhmouz MM, Abuhalimeh R, Abuhalimeh L, Chin J, Qadura M, Younes H, Abuhalimeh BJ.   +7 more
europepmc   +1 more source

The histone deacetylase inhibitor, suberoylanilide hydroxamic acid, restores blood–brain barrier integrity in a human stem cell‐based model of ischaemic stroke

British Journal of Pharmacology, Volume 183, Issue 19, Page 5791-5812, October 2026.
Ischaemic stroke is characterised by acute cerebrovascular occlusion and blood–brain barrier (BBB) breakdown. Our results indicated that the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA) ameliorated the loss of BBB integrity, changed the morphology of brain endothelial cells, increased the level of basement membrane and ...
Anikó Szecskó, Koppány Párdi, Zuhao Cui, Gergő Porkoláb, Zsófia Hoyk, Csilla Kovács, Janet F. Adegbite, Virág Fodor, Nárcisz M. Cser, László Dér, Krisztina Nagy, Csilla Sajben, Roland Tengölics, Mária A. Deli, Szilvia Veszelka   +14 more
wiley   +1 more source

Associations Between Chocolate Consumption and Cardiometabolic Risk Markers Across Metabolic Profiles: Insights from a Population-Based Study. [PDF]

Nutrients
Martín-Carro B, Iglesias-Colino E, Montes-Riesgo D, Cascón S, Nieto-García L, Romero A, Pérez-Sánchez P, Sánchez-Puente A, Varas-Marcos I, Blázquez B, Pérez Del Villar C, Cembrero-Fuciños D, Muriel P, Moyano-Maza JC, Santolino I, Martín-Gallego A, González-González L, Maíllo-Seco J, Ruiz-Olgado MJ, Rincón LM, Isidoro-García M, Sánchez PL.   +21 more
europepmc   +1 more source

Indole‐3‐Propionic Acid Drives Dendritic H3K27 Acetylation to Enhance CD8+ T Cell Immunity in Hepatocellular Carcinoma

Cancer Science, Volume 117, Issue 10, Page 2705-2718, October 2026.
The gut microbiota metabolite indole ‐ 3 ‐ propionic acid（IPA) enhanced the inhibitory effect of SCB on tumor growth in HCC mice. IPA upregulated IL‐12A expression through facilitating acetylation of H3K27 in DCs. IPA elevated IL‐12A expression in DCs to promote CD8+ T cell anti‐tumor immunity and ultimately enhances the efficacy of SCB therapy against
Rui Zhao, Siqi Liu, Qian Zhang, Wenrui Wang, Lanlan Yang, Xue Shao, Shengnan Jia, Zhenjing Jin   +7 more
wiley   +1 more source

Integrated Transcriptomic and Proteomic Analysis of the Pathogenic Mechanisms of <i>Staphylococcus aureus</i>-Induced Gangrenous Mastitis in Dairy Goats. [PDF]

Animals (Basel)
Fu M, Tan X, Liu Y, Zhang W, Zhuang S, An X, Fan Y.   +6 more
europepmc   +1 more source