Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source
Partial substitution of concentrates by maize silage in rations for organic dairy cows and its influence on performance and utilization efficiency [PDF]
, 2006 The aim of the present study was to investigate the influence of partial substitution of purchased concentrates with maize silage on feed intake, energy and nutrient supply, milk production and feed utilization efficiency in organic dairy cows.
Baumung, Roswitha +3 more
core
Fluorescence-based analyser as a rapid tool for determining soluble protein content in dairy ingredients and infant milk formula [PDF]
, 2018 peer-reviewedAbstract: Milk protein, in particular native whey protein, is of interest to dairy manufacturers as a measure of functional and nutritional quality.
Esquerre, Carlos +4 more
core +1 more source
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
The effect of preservation method of barley, maturity of grass silage, and type of protein supplementation on sensoric milk quality in organic farming [PDF]
, 2006 Three continuous production experiments and three short term cross over experiments were carried out in Northern Norway to investigate different feeding strategies for dairy cows in organic farming.
Adler, Steffen A., Randby, Åshild T.
core
Effects of peripartum biotin supplementation of dairy cows on milk production and milk composition with emphasis on fatty acids profile [PDF]
, 2008 Forty Holstein dairy cows receiving a 38% concentrate diet based on maize silage were assigned to either a control group, either a biotin group, receiving 20 mg of biotin per day from 15 days before expected calving date and for 120 days after calving ...
Enjalbert, Francis +2 more
core +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Nutrient utilisation, growth and chemical body composition of pre-weaned lambs reared artificially : effects of feeding milk replacer and pellets : a thesis presented in partial fulfilment of the requirements for the degree of Doctor of Philosophy in Animal Science at Massey University, Palmerston North, Manawatū, New Zealand [PDF]
, 2016 Listed in 2016 Dean's List of Exceptional ThesesUnderstanding how nutrient supply controls lamb growth is important in improving the efficiency of nutrient utilisation.
Danso, Antoinette Simpah
core
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Annual rhythms of milk, fat, and protein production in Holstein cows
Ciência e AgrotecnologiaEnvironmental factors and animal diet contribute to seasonal variations in milk production and composition over the year. However, these annual production patterns may result from an endogenous yearly rhythm that regulates milk synthesis in the animals ...
Juscilene Aparecida Silva Pacheco +3 more
doaj +1 more source