Results 181 to 190 of about 936,581 (316)

Inhibition of SLC11A1‐Mediated Lysosomal Iron Accumulation in Microglia Promotes Repair Following White Matter Stroke

Advanced Science, EarlyView.
Genetic and pharmacological inhibition of SLC11A1 functioning as an H+/Fe2+ antiporter–mediated lysosomal iron accumulation in microglia promotes lysosomal lumen acidification, increases CTSD expression, enhances lysosomal myelin debris uptake and degradation, and promotes repair following white matter stroke. ABSTRACT White matter stroke (WMS) results
Lingling Qiu, Yajie Zhang, Yushi Tang, Hongli Hu, Ying Zhang, Junwen Xue, Hao Wang, Yecheng Wang, Chunfeng Liu, Jia Jia, Jian Cheng, Yongjun Cao   +11 more
wiley   +1 more source

Effects of Adding Sodium Diacetate and <i>Aspergillus oryzae</i> to TMR Diets on Lactating Camel Production Performance, Milk Quality, and Fecal Microbiota. [PDF]

Vet Sci
Wang Z, Wu J, Song D, Deng Q, Har A, Zhang Z, Zheng W.   +6 more
europepmc   +1 more source

Management Practices of Bovine Mastitis and Milk Quality on Egyptian Dairies. [PDF]

Vet Sci, 2023
Farag HS, Aly SS, Fahim KM, Fayed AA, Abdelfattah EM, El-Sayed SM, Hegazy YM, ElAshmawy WR.   +7 more
europepmc   +1 more source

Versatile CRISPR‐Cas Tools for Gene Regulation in Zebrafish via an Enhanced Q Binary System

Advanced Science, EarlyView.
This study introduces CRISPR‐Q, a transgenic CRISPR‐Cas system leveraging the QFvpr/QUAS binary expression platform in zebrafish. CRISPR‐Q overcomes previous challenges in achieving stable and efficient gene regulation. By enabling precise spatiotemporal control of transcript knockdown (CRISPR‐QKD) and gene activation (CRISPR‐Qa), it provides a ...
Miaoyuan Shi, Weiqi Ge, Changheng Li, Bin Liu, Xiaoyi Deng, Chengjie Liu, Meijun Zheng, Pu Zhang, Lei Li, Ying Guo, Yunqi Han, Yu Yang, Yanxun V. Yu, Youngnam N. Jin   +13 more
wiley   +1 more source

Prevalence and Farm Management Factors and Milk Quality Changes Related to Bovine Mastitis in Small- and Medium-Sized Farms in the Central Highlands of Ecuador. [PDF]

Vet Med Int
Maya-Delgado A, Ron-Garrido L, Balarezo-Espinoza K, Poveda-Tutasi MJ, Cholota-Iza C, Chávez-Larrea MA, Reyna-Bello A, Martin-Solano S, Saegerman C, Ron-Román J.   +9 more
europepmc   +1 more source

Farnesyltransferase Deficiency in Cardiomyocytes Initiates Senescence and Contributes to Cardiac Fibrosis

Advanced Science, EarlyView.
Lipid overload suppresses SREBF2‐mediated FNTB expression, leading to defective Lamin A maturation and nuclear envelope instability. This nuclear catastrophe triggers a pro‐fibrotic senescence program in cardiomyocytes. Notably, restoring nuclear integrity via AAV9‐based gene therapy effectively attenuates cardiac remodeling, identifying the ...
Yuxiao Chen, Lian Lou, Xuan Zhang, Lin Yan, Qi Zhang, Wen Shi, Jie Ding, Xu Lin, Rong Jiang, Shuo Liu, Thida Sok, Pengli Wang, Yun Mou, Jie Han, Shenjiang Hu, Xiaogang Guo, Jian Yang   +16 more
wiley   +1 more source

Purslane supplementation improved antioxidant capacity and milk quality potentially through rumen microbiota in dairy goats. [PDF]

Anim Nutr
Wang M, Ren Y, Shen H, Li K, Xu X, Shi H.   +5 more
europepmc   +1 more source

PDZK1‐ULK1 Axis Triggers Lipophagy to Inhibit Tumor Progression and Sunitinib Resistance in Clear Cell Renal Cell Carcinoma

Advanced Science, EarlyView.
This study reveals that PDZK1 loss impairs ULK1‐mediated lipophagy, driving lipid droplet accumulation and sunitinib resistance in clear cell renal cell carcinoma. PDZK1 inhibits LEF1 nuclear translocation, enhancing ULK1 transcription. Pharmacological ULK1 activation resensitizes resistant tumors to sunitinib.
Xuan Qi, Yu Guo, Yumeng Yang, Haibo Wang, Xiaomei Yang, Ran Song, Qiong Qin, Yan Zhang, Meihan Hu, Haixing Zhou, Duiping Feng, Junqi He   +11 more
wiley   +1 more source

An Inexpensive AI-Powered IoT Sensor for Continuous Farm-to-Factory Milk Quality Monitoring. [PDF]

Sensors (Basel)
Fizza K, Banerjee A, Georgakopoulos D, Jayaraman PP, Yavari A, Dawod A.   +5 more
europepmc   +1 more source

Milk Quality Conceptualization: A Systematic Review of Consumers', Farmers', and Processing Experts' Views. [PDF]

Foods, 2023
Castellini G, Castellini G, Barello S, Bosio AC.   +3 more
europepmc   +1 more source