Results 61 to 70 of about 4,796,996 (337)
ERBIN limits epithelial cell plasticity via suppression of TGF‐β signaling
FEBS Letters, EarlyView.In breast and lung cancer patients, low ERBIN expression correlates with poor clinical outcomes. Here, we show that ERBIN inhibits TGF‐β‐induced epithelial‐to‐mesenchymal transition in NMuMG breast and A549 lung adenocarcinoma cell lines. ERBIN suppresses TGF‐β/SMAD signaling and reduces TGF‐β‐induced ERK phosphorylation.
Chao Li +3 more
wiley +1 more source
Stellar Bars in Isolated Gas-rich Spiral Galaxies Do Not Slow Down
The Astrophysical Journal, 2023 Elongated bar-like features are ubiquitous in galaxies, occurring at the centers of approximately two-thirds of spiral disks in the nearby Universe. Due to gravitational interactions between the bar and the other components of galaxies, it is expected ...
Angus Beane +8 more
doaj +1 more source
Evidence for two early accretion events that built the Milky Way stellar halo [PDF]
Monthly notices of the Royal Astronomical Society, 2019 The Gaia Sausage is the major accretion event that built the stellar halo of the Milky Way galaxy. Here, we provide dynamical and chemical evidence for a second substantial accretion episode, distinct from the Gaia Sausage. The Sequoia Event provided the
G. Myeong +7 more
semanticscholar +1 more source
FEBS Letters, EarlyView.Spinal muscular atrophy (SMA) is a genetic disease affecting motor neurons. Individuals with SMA experience mitochondrial dysfunction and oxidative stress. The aim of the study was to investigate the effect of an antioxidant and neuroprotective substance, ergothioneine (ERGO), on an SMNΔ7 mouse model of SMA.
Francesca Cadile +8 more
wiley +1 more source
Candidate Members of the VMP/EMP Disk System of the Galaxy from the SkyMapper and SAGES Surveys
The Astrophysical Journal Supplement SeriesPhotometric stellar surveys now cover a large fraction of the sky, probe to fainter magnitudes than large-scale spectroscopic surveys, and are relatively free from the target selection biases often associated with such studies.
Jihye Hong +17 more
doaj +1 more source
Origin of the system of globular clusters in the Milky Way [PDF]
Astronomy & Astrophysics, 2019 Context. The assembly history experienced by the Milky Way is currently being unveiled thanks to the data provided by the Gaia mission. It is likely that the globular cluster system of our Galaxy has followed a similarly intricate formation path.
D. Massari, H. Koppelman, A. Helmi
semanticscholar +1 more source
Constraints on the properties of warm dark matter using the satellite galaxies of the Milky Way [PDF]
, 2020 The satellite galaxies of the Milky Way (MW) are effective probes of the underlying dark matter (DM) substructure, which is sensitive to the nature of the DM particle. In particular, a class of DM models have a power spectrum cut-off on the mass scale of
Oliver Newton +8 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu +11 more
wiley +1 more source