Results 61 to 70 of about 151,078 (334)
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Dynamical evolution of a bulge in an N-body model of the Milky Way [PDF]
, 2011 The detailed dynamical structure of the bulge in the Milky Way is currently under debate. Although kinematics of the bulge stars can be well reproduced by a boxy-bulge, the possible existence of a small embedded classical bulge can not be ruled out.
Gerhard, Ortwin +2 more
core +2 more sources
The baryons in the Milky Way satellites [PDF]
Monthly Notices of the Royal Astronomical Society, 2011 We investigate the formation and evolution of satellite galaxies using smoothed particle hydrodynamics (SPH) simulations of a Milky Way(MW)-like system, focussing on the best resolved examples, analogous to the classical MW satellites. Comparing with a pure dark matter simulation, we find that the condensation of baryons has had a relatively minor ...
Vincent R. Eke +4 more
openaire +6 more sources
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
The Astrophysical JournalUnderstanding the physical mechanism behind the formation of a corotating thin plane of satellite galaxies, like the one observed around the Milky Way (MW), has been challenging.
Nicolás Garavito-Camargo +10 more
doaj +1 more source
Chemodynamical modelling of the Milky Way [PDF]
Astronomische Nachrichten, 2016 AbstractChemodynamical models of our Galaxy that have analytic Extended Distribution Functions (EDFs) are likely to play a key role in extracting science from surveys in the era of Gaia.
J. Binney, J. L. Sanders
openaire +4 more sources
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Mapping the Chemodynamics of the Galactic Disk Using the LAMOST and APOGEE Red Clump Stars
The Astrophysical Journal Supplement SeriesA detailed measurement is made of the metallicity distributions, kinematics, and dynamics of the thin and thick disks across a large disk volume (5.0 ≤ R ≤ 15.0 kpc and ∣ Z ∣ ≤ 3.0 kpc) by using the LAMOST–APOGEE red clump stars.
Weixiang Sun +3 more
doaj +1 more source
Stellar Bars in Isolated Gas-rich Spiral Galaxies Do Not Slow Down
The Astrophysical Journal, 2023 Elongated bar-like features are ubiquitous in galaxies, occurring at the centers of approximately two-thirds of spiral disks in the nearby Universe. Due to gravitational interactions between the bar and the other components of galaxies, it is expected ...
Angus Beane +8 more
doaj +1 more source
The Chemical Evolution of the Milky Way
, 1999 The field of chemical evolution modeling of the Galaxy is experiencing in the last years a phase of high activity and important achievements. There are, however, several open questions which still need to be answered. In this review I summarize what have
A Pasquali +27 more
core +1 more source