Results 81 to 90 of about 151,078 (334)

Report on the 2nd MObility for Vesicle research in Europe (MOVE) symposium—2024

FEBS Open Bio, EarlyView.
The 2nd MObility for Vesicle research in Europe (MOVE) Symposium in Belgrade brought over 280 attendees from 28 countries to advance extracellular vesicle (EV) research. Featuring keynotes, presentations, and industry sessions, it covered EV biogenesis, biomarkers, therapies, and manufacturing.
Dorival Mendes Rodrigues‐Junior, Michaela Kocholata, Marilena E. Lekka, Olga Janouskova, Moran Yadid, Maja Kosanovic   +5 more
wiley   +1 more source

Lactoferrin treatment activates acetylcholinesterase, decreasing acetylcholine levels in non‐small cell lung cancer (NSCLC) cell culture supernatants, inhibiting cell survival

FEBS Open Bio, EarlyView.
Representation of the suggested mode of action of lactoferrin (Lf) in nonsmall cell lung cancer (NSCLC) A549 cells. Lf induces activation of caspase‐3 by activating p53 and AChE leading to decreased ACh concentrations. In turn, ACh signaling leads to activation of VEGF and AKT and blocking of caspase‐3.
Stuti Goel, Caroline Wozniak, Aya Sabri, Ben Haddad, Brooke Lopo, Alvaro Cobos, Sarah Sarofim, Jeffrey Guthrie, Deborah Heyl, Hedeel Guy Evans   +9 more
wiley   +1 more source

The Rapid Formation of the Metal-poor Milky Way

The Astrophysical Journal
Our understanding of the assembly timeline of the Milky Way has been transforming along with the dramatic increase in astrometric and spectroscopic data available over the past several years.
Turner Woody, Charlie Conroy, Phillip Cargile, Ana Bonaca, Vedant Chandra, Jiwon Jesse Han, Benjamin D. Johnson, Rohan P. Naidu, Yuan-Sen Ting   +8 more
doaj   +1 more source

Polarisation properties of Milky-Way-like galaxies

, 2012
(Abridged) We study the polarisation properties, magnetic field strength, and synchrotron emission scale-height of Milky-Way-like galaxies in comparison with other spiral galaxies.
Beck, Beck, Beck, Beck, Beuermann, Braun, Brown, Brown, Cox, Dumke, Dumke, Fleishman, Gaensler, Gold, Gold, Górski, Han, Haslam, Heald, Heesen, Heesen, Hill, Johnston, Niklas, Nord, Noutsos, Page, Phillipps, Roger, Soida, Sokoloff, Stil, Sun, Sun, Sun, Sun, Taylor, Testori, Van Eck, W. Reich, Waelkens, Wolleben, X. H. Sun   +42 more
core   +1 more source

HSP70 governs permeability and mechanotransduction in primary human endothelial cells

FEBS Open Bio, EarlyView.
HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez, Everton G. Melo, Isadora C. B. Pavan, Percíllia V. S. Oliveira, Luiza B. C. T. Coimbra, Thaís L. S. Araujo   +5 more
wiley   +1 more source

Windows in the Milky Way [PDF]

The objectives were twofold: (1) to study the IRAS emission levels in the vicinity of Baade's Window and in other optically transparent regions near the Galactic Center; and (2) to study the IRAS emission levels along sightlines in the Milky Way that ...
Boulanger, Francois, Okumura, Koryo, Tacconi-Garman, Lowell Evan, Waller, William H.   +3 more
core   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

Constraining the Milky Way Halo Accretion History with Simulated Stellar Halos: Designing the HALO7D-X Survey

The Astrophysical Journal
We present the design for HALO7D-X, a survey of the stellar halo to investigate the accretion history of the Milky Way. The survey will use a combination of Hubble Space Telescope (HST) and Gaia data for sky position and proper motions of faint stars (18 
Miranda Apfel, Kevin McKinnon, Constance M. Rockosi, Puragra Guhathakurta, Kathryn V. Johnston   +4 more
doaj   +1 more source

Dynamical Models for the Milky Way

, 1996
The only way to map the Galaxy's gravitational potential $\Phi({\bf x})$ and the distribution of matter that produces it is by modelling the dynamics of stars and gas. Observations of the kinematics of gas provide key information about gradients of $\Phi$
Binney, James, Dehnen, Walter
core  

Exploring Dark Matter with Milky Way substructure

, 2009
The unambiguous detection of Galactic dark matter annihilation would unravel one of the most outstanding puzzles in particle physics and cosmology. Recent observations have motivated models in which the annihilation rate is boosted by the Sommerfeld ...
Abdo, Aharonian, Aharonian, Chang, Diemand, Hisano, J. Silk, M. Kuhlen, P. Madau   +8 more
core   +1 more source