Results 51 to 60 of about 28,520 (293)

Observability of γ rays from dark matter neutralino annihilations in the Milky Way halo [PDF]

Astroparticle Physics, 1998
Recent advances in N-body simulations of cold dark matter halos point to a substantial density enhancement near the center. This means that, e.g., the $ $ ray signals from neutralino dark matter annihilations would be significantly enhanced compared to old estimates based on an isothermal sphere model with large core radius.
Bergström, L., Ullio, P., Buckley, J. H.   +2 more
openaire   +2 more sources

Gamma-rays From Warm WIMP Dark Matter Annihilation

, 2012
The weakly interacting massive particle (WIMP) often serves as a candidate for the cold dark matter, however when produced non-thermally it could behave like warm dark matter.
Bi, Xiao-Jun, Cao, Yixian, Gao, Liang, Liu, Jie, Yin, Peng-Fei, Yuan, Qiang, Zhang, Xinmin   +6 more
core   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Halo-to-Halo Similarity and Scatter in the Velocity Distribution of Dark Matter

, 2012
We examine the Velocity Distribution Function (VDF) in dark matter halos from Milky Way to cluster mass scales. We identify an empirical model for the VDF with a wider peak and a steeper tail than a Maxwell--Boltzmann distribution, and discuss physical ...
Hahn, Oliver, Mao, Yao-Yuan, Strigari, Louis E., Wechsler, Risa H., Wu, Hao-Yi   +4 more
core   +2 more sources

Investigating dark matter substructure with pulsar timing: I. Constraints on ultracompact minihalos [PDF]

, 2016
Small-scale dark matter structure within the Milky Way is expected to affect pulsar timing. The change in gravitational potential induced by a dark matter halo passing near the line of sight to a pulsar would produce a varying delay in the light travel ...
Clark, Hamish A., Lewis, Geraint F., Scott, Pat   +2 more
core   +2 more sources

Bimetallic Nanoreactor Activates cGAS‐STING Pathway via mtDNA Release for Cancer Metalloimmunotherapy

Advanced Functional Materials, EarlyView.
A bimetallic Mn–Ca nanoreactor (MCC) is developed as a non‐nucleotide STING nanoagonist for cancer metalloimmunotherapy. MCC induces Ca2+ overload and hydroxyl radical generation, resulting in mitochondrial damage and mtDNA release. The released mtDNA cooperates with Mn2+ to robustly activate cGAS–STING signaling.
Xin Wang Mo, Nguyen Thi Nguyen, LiLi Guo, Ngoc Man Phan, Hyunsu Shin, Tae‐il Kim, Yu Seok Youn, Jaeyun Kim   +7 more
wiley   +1 more source

Signature of a Dark Ultracompact Dwarf Galaxy Transiting the Milky Way Disk

The Astrophysical Journal Letters
We report the discovery of a vertical velocity anomaly in the stellar component of the Galactic disk, consistent with the impact of a dark, ultracompact dwarf galaxy (UCD)-sized object plunging into the Milky Way.
Ken Udagawa, Tomoharu Oka, Hiroki Yokozuka, Tatsuya Kotani   +3 more
doaj   +1 more source

Testing two alternatives theories to dark matter with the Milky Way dynamics

, 2015
Two alternative theories to dark matter are investigated by testing their ability to describe consistently the dynamics of the Milky Way. The first one refers to a modified gravity theory having a running gravitational constant and the second assumes ...
de Oliveira, P. L. C., Pacheco, J. A. de Freitas, Reinisch, G.   +2 more
core   +1 more source

Synthetic Nanobiology Actuated Lipometabolic Cell Factory for Autologous Tumor Immunotherapy

Advanced Functional Materials, EarlyView.
FA plays a crucial role in the interaction between tumor cells and the tumor microenvironment, especially for the immune response. A biocatalytic immunoenhancement strategy is developed to boost antitumor immunity by FA metabolic orientation to ceramide. Through the design of this delicate catalytic immunoenhancement strategy, the synthetic nanobiology
Shoujie Zhao, Yejing Zhu, Hengchao Yu, Jun Zhu, Bo Wang, Yu Qiao, Zhimin Tian, Junlong Zhao, Lei Liu   +8 more
wiley   +1 more source

VIVID: A qPCR‐Based Platform for Sensitive and Quantitative In Vivo Tracking of Extracellular Vesicles

Advanced Functional Materials, EarlyView.
This study introduces VIVID (Vesicle In Vivo Identification using DNA), a qPCR‐based platform that tracks PCR‐amplifiable DNA tags loaded in the EVs for accurate and quantifiable EV biodistribution in vivo. ABSTRACT Extracellular vesicles (EVs) represent promising carriers for nucleic acid therapeutics, offering advantages over synthetic nanoparticles ...
Oscar Boyadjian, Talin Ebrahimian, Jonathan Miranda O'Connor, Janusz Rak, Stephanie Lehoux, Maryam Tabrizian   +5 more
wiley   +1 more source