Results 61 to 70 of about 7,809,762 (287)

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

The DREAMS Project: Disentangling the Impact of Halo-to-Halo Variance and Baryonic Feedback on Milky Way Dark Matter Speed Distributions

The Astrophysical Journal
Dark matter direct detection experiments require information about the local dark matter speed distribution to produce constraints on dark matter candidates, or infer their properties in the event of a discovery.
Ethan Lilie, Jonah C. Rose, Mariangela Lisanti, Alex M. Garcia, Paul Torrey, Kassidy E. Kollmann, Jiaxuan Li, Olivia Mostow, Bonny Y. Wang, Stephanie O’Neil, Xuejian Shen, Alyson M. Brooks, Arya Farahi, Nitya Kallivayalil, Lina Necib, Andrew B. Pace, Mark Vogelsberger   +16 more
doaj   +1 more source

Implications for dark matter direct detection in the presence of LIGO-motivated primordial black holes

Physics Letters B, 2020
We discuss formation of dark matter (DM) mini-halos around primordial black holes (PBHs) and its implication on DM direct detection experiments, including axion searches.
Mark P. Hertzberg, Enrico D. Schiappacasse, Tsutomu T. Yanagida   +2 more
doaj   +1 more source

On the phase-space structure of the Milky Way dark-matter halo

, 2001
4 pages, 5 figures, uses dunk2001_asp.sty, to appear in "The Dynamics, Structure and History of Galaxies: A Workshop in Honour of Prof. Ken Freeman", (eds) G. S. Da Costa & E. M.
Helmi, Amina, Springel, Volker, White, Simon D.~M.   +2 more
openaire   +3 more sources

Observability of γ rays from dark matter neutralino annihilations in the Milky Way halo [PDF]

Astroparticle Physics, 1998
44 pages, LaTex, eps figures embedded with epsfig and subfigure ...
Bergström, L., Ullio, P., Buckley, J. H.   +2 more
openaire   +2 more sources

The Clustering of Dark Matter, Haloes & Galaxies [PDF]

, 2008
In this thesis I study the spatial distribution of galaxies, haloes and dark matter particlesin the Universe. The subjects investigated are conceptually divided into three areas.One line of research, which is made up of Chapters 2 and 3， is to explore ...
Raúl Esteban Angulo de la Puente,
core  

A Magneto‐Mechanically Activated Nerve Guidance Conduit Promotes Peripheral Nerve Regeneration via TIMP1‐Mediated Membrane Tension Transfer

Advanced Functional Materials, EarlyView.
This study presents a magneto‐mechanical strategy that incorporates FP@MSCs into an aligned PCL/GelMA nerve guidance conduit. Magnetic stimulation increases membrane tension in FP@MSCs, triggering cytoskeletal remodeling, Schwann cell‐like differentiation, and TIMP1 secretion. TIMP1 activates ITGB1/CD63–FAK signaling in NE‐4C cells, increasing membrane
Xinyu Zhu, Yumin Wu, Xiang Gao, Tianlu Wang, Wanting Jia, Xueying Mei, Huanzhong Ji, Zongxi Wu, Yujie Liang, Xiang Li, Kan Li, Jingyuan Li, Guangsen Zheng, Guiqing Liao, Siyong Gao   +14 more
wiley   +1 more source

Symphony: Cosmological Zoom-in Simulation Suites over Four Decades of Host Halo Mass

The Astrophysical Journal, 2023
We present Symphony, a compilation of 262 cosmological, cold-dark-matter-only zoom-in simulations spanning four decades of host halo mass, from 10 ^11 –10 ^15 M _⊙ .
Ethan O. Nadler, Philip Mansfield, Yunchong Wang, Xiaolong Du, Susmita Adhikari, Arka Banerjee, Andrew Benson, Elise Darragh-Ford, Yao-Yuan Mao, Sebastian Wagner-Carena, Risa H. Wechsler, Hao-Yi Wu   +11 more
doaj   +1 more source

PLL‐g‐HPA Hydrogel Microneedles Loaded With Rhoifolin Target Macrophages to Alleviate Fibroblast Senescence for Diabetic Wound Healing

Advanced Healthcare Materials, EarlyView.
Diabetic wound healing is hindered by a pathological crosstalk wherein elevated IL‐11 induces M1 macrophage polarization, leading to IL‐1β/IL‐6 release and subsequent fibroblast senescence via RAS/p38MAPK/p53/E2F1 signaling. Here, we develop a Gel@M‐Rho microneedle patch that delivers rhoifolin‐loaded, macrophage membrane‐coated nanoparticles to target
Jiewen Liao, Lin Gan, Li Lu, Lizhi Ouyang, Yuan Xiong, Fawwaz Al‐Smadi, Guandong Dai, Mohammad‐Ali Shahbazi, Bobin Mi, Mengfei Liu, Guohui Liu   +10 more
wiley   +1 more source

The DREAMS Project: Disentangling the Impact of Halo-to-halo Variance and Baryonic Feedback on Milky Way Dark Matter Density Profiles

The Astrophysical Journal
In this work, we utilize a new suite of Milky Way–mass halos from the DREAMS Project, simulated with cold dark matter (CDM), to quantify the influence of baryon feedback and intrinsic halo-to-halo variance on dark matter density profiles.
Alex M. Garcia, Jonah C. Rose, Paul Torrey, Andrea Caputo, Mariangela Lisanti, Andrew B. Pace, Hongwan Liu, Abdelaziz Hussein, Haozhe Liu, Francisco Villaescusa-Navarro, John Barry, Ilem Leisher, Belén Costanza, Jonathan Kho, Ethan Lilie, Jiaxuan Li, Niusha Ahvazi, Aklant Bhowmick, Tri Nguyen, Stephanie O’Neil, Xiaowei Ou, Xuejian Shen, Arya Farahi, Nitya Kallivayalil, Lina Necib, Mark Vogelsberger   +25 more
doaj   +1 more source