Results 61 to 70 of about 28,645 (286)

ELABELA Targets Mitochondria to Modulate Heart Development

Advanced Science, EarlyView.
The role of peptide ELABELA (ELA) in cardiomyocyte apoptosis and congenital heart disease (CHD) is unclear. ELA deficiency caused cardiomyocyte apoptosis and CHD. A novel ELA‐APJ‐AKT‐BCL2/BAX axis in regulating mitochondrial function and contributing to CHD pathogenesis was established.
Jian Wang, Qingjie Wang, Zhikang Xu, Shuang Zhou, Yue Zhou, Junjie Yang, Lingfeng Tong, Zhuo Meng, Mei Yang, Wen Zhao, Tie Yang, Hualin Wang, Jun Zhang, Rubin Tan, Lei Wang, Yuqiang Huang, Bin Zhou, Sun Chen, Bing Zhang, Jinxiang Yuan, Jianyuan Zhao, Alex F. Chen, Kun Sun   +22 more
wiley   +1 more source

The DREAMS Project: Disentangling the Impact of Halo-to-halo Variance and Baryonic Feedback on Milky Way Dark Matter Density Profiles

The Astrophysical Journal
In this work, we utilize a new suite of Milky Way–mass halos from the DREAMS Project, simulated with cold dark matter (CDM), to quantify the influence of baryon feedback and intrinsic halo-to-halo variance on dark matter density profiles.
Alex M. Garcia, Jonah C. Rose, Paul Torrey, Andrea Caputo, Mariangela Lisanti, Andrew B. Pace, Hongwan Liu, Abdelaziz Hussein, Haozhe Liu, Francisco Villaescusa-Navarro, John Barry, Ilem Leisher, Belén Costanza, Jonathan Kho, Ethan Lilie, Jiaxuan Li, Niusha Ahvazi, Aklant Bhowmick, Tri Nguyen, Stephanie O’Neil, Xiaowei Ou, Xuejian Shen, Arya Farahi, Nitya Kallivayalil, Lina Necib, Mark Vogelsberger   +25 more
doaj   +1 more source

Substructure in CDM Halos and the Heating of Stellar Disks [PDF]

, 2001
Numerical simulations have revealed the presence of long-lived substructure in Cold Dark Matter (CDM) halos. These surviving cores of past merger and accretion events vastly outnumber the known satellites of the Milky Way.
Navarro, Julio F.
core   +3 more sources

Observability of γ rays from dark matter neutralino annihilations in the Milky Way halo [PDF]

Astroparticle Physics, 1998
44 pages, LaTex, eps figures embedded with epsfig and subfigure ...
Bergström, L., Ullio, P., Buckley, J. H.   +2 more
openaire   +2 more sources

QBP1 Peptide as a Potential Anti‐Amyloidogenic Therapy for Type 2 Diabetes: An In Vitro Study

Advanced Science, EarlyView.
The anti‐amyloidogenic peptide QBP1 effectively halts human islet amyloid polypeptide (hIAPP) aggregation, preventing the formation of toxic β‐structured intermediates. Through a combination of biophysical assays, molecular dynamics, and cell‐based studies, QBP1 is shown to preserve β‐cell viability and metabolic homeostasis, positioning it as a ...
María M. Tejero‐Ojeda, Ada Bernaus Vives, Michał Wojciechowski, Dinh Quoc Huy Pham, Mateusz Chwastyk, Mario Vallejo, Anna Novials, Douglas V. Laurents, Mariano Carrión‐Vázquez   +8 more
wiley   +1 more source

A Study of the Dynamical Structures in a Dark Matter Halo Using UMAP

The Astrophysical Journal
We use a dimension reduction algorithm, Uniform Manifold Approximation and Projection (UMAP), to study dynamical structures inside a dark matter halo. We use a zoom-in simulation of a Milky Way mass dark matter halo and apply UMAP to the six-dimensional ...
Soorya Narayan, Susmita Adhikari
doaj   +1 more source

Evolution of the Dark Matter Phase-Space Density Distributions of LCDM Halos [PDF]

, 2009
We study the evolution of phase-space density during the hierarchical structure formation of LCDM halos. We compute both a spherically-averaged surrogate for phase-space density (Q) and the coarse-grained distribution function f(x,v) for dark matter ...
Andrey V. Kravtsov, Arad, Ascasibar, Ascasibar, Austin, Barnes, Barnes, Bertschinger, Binney, Borgani, Cuesta, Dehnen, Dehnen, Diemand, Faltenbacher, Gnedin, Hoffman, Hogan, Ileana M. Vass, Kazantzidis, Klypin, Knollmann, Kravtsov, Kravtsov, Li, Maciejewski, Mathur, Merritt, Monica Valluri, Navarro, Rasia, Sharma, Stadel, Stelios Kazantzidis, Taylor, Tozzi, Tremaine, Tremaine, Valluri, Vass, Vogelsberger, Voit, Wang, Wojtak   +43 more
core   +1 more source

Marburg Virus Glycoprotein Is a Remarkable Virulent Factor Linked to Hemorrhagic Pathology: Evidence from Multimodal Experimental Systems

Advanced Science, EarlyView.
By integrating data from in vitro, ex vivo, and in vivo models, our research identifies the MARV glycoprotein as a remarkable hemorrhagic factor, filling a major gap in this important field. It also provides practical experimental tools for the basic research on viral pathogenesis and applied research aimed at antiviral intervention for hemorrhagic ...
Ting Yao, Hang Liu, Yanfeng Yao, Wei Deng, Jiawen Sun, Zhenyu Kang, Ashaq Ali, Chao Shan, Zhiming Yuan, Fei Deng, Hualin Wang, Yun‐Jia Ning   +11 more
wiley   +1 more source

On the Corotation of Milky Way Satellites: LMC-mass Satellites Induce Apparent Motions in Outer Halo Tracers

The Astrophysical Journal
Understanding the physical mechanism behind the formation of a corotating thin plane of satellite galaxies, like the one observed around the Milky Way (MW), has been challenging.
Nicolás Garavito-Camargo, Adrian M. Price-Whelan, Jenna Samuel, Emily C. Cunningham, Ekta Patel, Andrew Wetzel, Kathryn V. Johnston, Arpit Arora, Robyn E. Sanderson, Lehman Garrison, Danny Horta   +10 more
doaj   +1 more source

Halo-to-Halo Similarity and Scatter in the Velocity Distribution of Dark Matter

, 2012
We examine the Velocity Distribution Function (VDF) in dark matter halos from Milky Way to cluster mass scales. We identify an empirical model for the VDF with a wider peak and a steeper tail than a Maxwell--Boltzmann distribution, and discuss physical ...
Hahn, Oliver, Mao, Yao-Yuan, Strigari, Louis E., Wechsler, Risa H., Wu, Hao-Yi   +4 more
core   +2 more sources