Results 81 to 90 of about 7,809,762 (287)

Minimum-entropy Constraints on Galactic Potentials

The Astrophysical Journal
A tracer sample in a gravitational potential, starting from a generic initial condition, phase-mixes toward a stationary state. This evolution is accompanied by an entropy increase, and the final state is characterized by a distribution function (DF ...
Leandro Beraldo e Silva, Monica Valluri, Eugene Vasiliev, Kohei Hattori, Walter de Siqueira Pedra, Kathryne J. Daniel   +5 more
doaj   +1 more source

Constraints on the parameters of radiatively decaying dark matter from the dark matter halos of the Milky Way and Ursa Minor [PDF]

Astronomy & Astrophysics, 2007
We improve the earlier restrictions on parameters of the dark matter (DM) in the form of a sterile neutrino. The results were obtained from non-observing the DM decay line in the X-ray spectrum of the Milky Way (using the recent XMM-Newton PN blank sky data).
Boyarsky, Alexey, Nevalainen, Jukka, Ruchayskiy, Oleg   +2 more
openaire   +2 more sources

Lactiplantibacillus Plantarum GUANKE Alleviates Allergic Asthma by Restricting Monocyte‐to‐DC Differentiation Via Microbiota‐Associated IAA

Advanced Science, EarlyView.
Lactiplantibacillus plantarum GUANKE remodels the indigenous gut microbiota and is associated with microbiota‐dependent restoration of circulating IAA. IAA treatment attenuates JAK3‐STAT3 and Jag1‐Notch4‐Hey1 signaling and reduces CX3CR1+Ly6C− monocytic precursor generation and pulmonary CD11b+ DC accumulation, together with reduced Th2 inflammation ...
Yujia He, Jielan Mi, Zhiping Zhao, Xiao Zhang, Zhihan Yang, Kun Yue, Yuanming Huang, Liqiong Song, Xiaoting Wen, Jianguo Xu, Zhihong Ren   +10 more
wiley   +1 more source

Semianalytic Modeling of Dark Matter Subhalo Encounters with Thin Stellar Streams: Statistical Predictions for GD-1-like Streams in Cold Dark Matter

The Astrophysical Journal
Stellar streams from disrupted globular clusters are dynamically cold structures that are sensitive to perturbations from dark matter subhalos, allowing them in principle to trace the dark matter substructure in the Milky Way.
Duncan K. Adams, Aditya Parikh, Oren Slone, Rouven Essig, Manoj Kaplinghat, Adrian M. Price-Whelan   +5 more
doaj   +1 more source

Astrocytic LMP2 Coordinates NF‐κB and TGF‐β1/Smad3 Signaling to Drive Neuroinflammation after Cerebral Ischemia/Reperfusion

Advanced Science, EarlyView.
ABSTRACT Astrocyte reactivity critically shapes neuroinflammatory outcomes after ischemic stroke, yet the upstream regulators governing astrocyte state transitions remain incompletely defined. Here, we identify the immunoproteasome subunit low molecular weight protein 2 (LMP2) as an important modulator of astrocyte functional remodeling following ...
Yanguang Mao, Rulan Ma, Zejing Lin, Huiying Zhao, Yuexian Liu, Yonghe Su, Xu Zhang, Xingyong Chen   +7 more
wiley   +1 more source

Simulations of satellite tidal debris in the Milky Way halo

, 2020
Aims. We study the distribution of the stellar and dark matter debris of the Milky Way satellites. Methods. For the first time we address the question of the tidal disruption of satellites in simulations by utilising simultaneously (a) a realistic set of
Andreas Just, Andrea V. Macciò, Matteo Mazzarini, Reza Moetazedian   +3 more
core   +1 more source

Mitochondrial SLC25A46 Rewires Fatty Acid Oxidation to Promote Cell Proliferation and Ferroptosis Evasion in Ovarian Cancer by Stabilizing CACT

Advanced Science, EarlyView.
Mitochondrial SLC25A46 is upregulated in ovarian cancer (OC) and correlates with poor prognosis. SLC25A46 stabilizes CACT to activate fatty acid oxidation, increasing ATP and NADPH production to drive cell proliferation and ferroptosis evasion. SLC25A46 silencing sensitizes OC cells to ferroptosis and carboplatin, offering a promising therapeutic ...
Yunge Gao, Jiatao Hao, Xiaohong Zhang, Meiting Long, Yujing Feng, Xiaoyue Liu, Xuejian Li, Shujuan Liu, Xin Guo, Xiaohui Lv   +9 more
wiley   +1 more source

Constraining the Tilt of the Milky Way's Dark Matter Halo with the Sagittarius Stream

, 2022
Recent studies have suggested that the Milky Way (MW)'s Dark Matter (DM) halo may be significantly tilted with respect to its central stellar disk, a feature that might be linked to its formation history. In this work, we demonstrate a method of constraining the orientation of the minor axis of the DM halo using the angle and frequency variables.
Panithanpaisal, Nondh, Sanderson, Robyn E., Arora, Arpit, Cunningham, Emily C., Baptista, Jay   +4 more
openaire   +2 more sources

EpCAM+ Extracellular Vesicle PD‐L1 Dynamics as a Predictive Biomarker of Immune Checkpoint Blockade Response

Advanced Science, EarlyView.
A highly sensitive SERS‐based platform measures PD‐L1 expression on EpCAM+ circulating EVs from cancer patients undergoing immunotherapy. Monitoring dynamic changes after treatment reveals that reduced EpCAM+ EV PD‐L1 levels associate with improved long‐term clinical outcomes, establishing a non‐invasive approach for tracking immune checkpoint ...
Byeonggeol Mun, Jinyoung Kim, Chang Gon Kim, Seokhyeong Go, Mina Han, Yujin Ouck, Soojin Jang, Seong Uk Son, Gamin Kim, Wonrak Son, Eunjung Kim, Min Hee Hong, Ja Hyun Yeo, Eun‐Kyung Lim, Hye Ryun Kim, Seungjoo Haam   +15 more
wiley   +1 more source

Tilted Dark Halos Are Common and Long-lived, and Can Warp Galactic Disks

The Astrophysical Journal Letters, 2023
In the Lambda cold dark matter paradigm, the dark halo governs the gravitational potential within which a galaxy can form and evolve. In this Letter we show that the present-day inner ( r < 50 kpc) dark halo can be significantly misaligned with the ...
Jiwon Jesse Han, Vadim Semenov, Charlie Conroy, Lars Hernquist   +3 more
doaj   +1 more source