Results 81 to 90 of about 28,645 (286)

Constraints on the parameters of radiatively decaying dark matter from the dark matter halos of the Milky Way and Ursa Minor [PDF]

Astronomy & Astrophysics, 2007
We improve the earlier restrictions on parameters of the dark matter (DM) in the form of a sterile neutrino. The results were obtained from non-observing the DM decay line in the X-ray spectrum of the Milky Way (using the recent XMM-Newton PN blank sky data).
Boyarsky, Alexey, Nevalainen, Jukka, Ruchayskiy, Oleg   +2 more
openaire   +2 more sources

Cryo‐EM Structure Guided Engineering of Botulinum Neurotoxin A With Advanced Receptor Binding Affinity and Therapeutical Benefits

Advanced Science, EarlyView.
The butterfly unfolded wing in an open form structure of botulinum neurotoxin type A (BoNT/A) at physiological‐state was confirmed at 2.85 Å resolution by cryo‐electron microscopy (cryo‐EM). Structure‐guided protein engineering significantly enhanced the receptor‐binding affinity, therapeutic efficacy, and safety of the engineered toxin variants ...
Wenrui Wang, Zhaxi Zerang, Linjin You, Ziye Liu, Rong Nie, Fuwei Qi, Fenfen Gao, Chengmu Zhao, Wantong Ma, Jinghan He, Xiaoru Wang, Shanquan Wu, Bo Liu, Xinyao Liu, Dongsheng Lei, Dejuan Zhi, Dongsheng Wang   +16 more
wiley   +1 more source

Semianalytic Modeling of Dark Matter Subhalo Encounters with Thin Stellar Streams: Statistical Predictions for GD-1-like Streams in Cold Dark Matter

The Astrophysical Journal
Stellar streams from disrupted globular clusters are dynamically cold structures that are sensitive to perturbations from dark matter subhalos, allowing them in principle to trace the dark matter substructure in the Milky Way.
Duncan K. Adams, Aditya Parikh, Oren Slone, Rouven Essig, Manoj Kaplinghat, Adrian M. Price-Whelan   +5 more
doaj   +1 more source

PET Imaging of Cardiac Inflammation in Viral Myocarditis Using a DPP4‐Targeted Probe

Advanced Science, EarlyView.
This study describes a DPP4‐targeted PET probe for imaging myocardial inflammation by selectively targeting activated immune cells. Derived from the clinically approved small‐molecule inhibitor linagliptin, the probe demonstrates favorable biodistribution with specific cardiac uptake in myocarditis.
Wanhao Gao, Wenzhu Hu, Du Tang, Xinxin Liu, Kun Yu, Lixia Feng, Minyu Liao, Wang Lin, Wenqiang Zhu, Sanjay Rajagopalan, Xiaoli Lan, Jixin Zhong, Dao Wen Wang, Dawei Jiang, Xiaoquan Rao   +14 more
wiley   +1 more source

The impact of baryons on the direct detection of dark matter

, 2016
The spatial and velocity distributions of dark matter particles in the Milky Way Halo affect the signals expected to be observed in searches for dark matter.
Bailin, Jeremy, Freese, Katherine, Kelso, Chris, Savage, Christopher, Stinson, Gregory S., Valluri, Monica   +5 more
core   +1 more source

A Functionally Conserved Enhancer is Critical for PGC1A Expression and Thermogenesis in Brown Fat

Advanced Science, EarlyView.
An evolutionarily conserved enhancer controls PGC1A expression and thermogenic activation in brown adipose tissue. Integrative multi‐omics analyses identify two BAT‐specific enhancers, with PGC1A‐En1 functioning as the dominant regulatory element that maintains thermogenic capacity across species.
Duo Su, Haosen Yang, Xiaokai Li, Tingting Jiang, Siyuan Zhan, Tao Zhong, Jiazhong Guo, Yan Wang, Li Li, Hongping Zhang, Linjie Wang   +10 more
wiley   +1 more source

Gut Lactate Boosts Ruminococcus via Histone Lactylation to Mediate Time‐Restricted Feeding Protection in Crohn's Disease

Advanced Science, EarlyView.
TRF enriches Ruminococcus, a bacterial genus producing SCFAs, and activates the epithelial HIF‐1α signaling pathway. This mechanism protects the colonic mucosa from inflammatory insults in colitis models. Mechanistically, gut lactate production during starvation and refeeding mediates H4K12la, which increases SLC9A3 expression and creates an acidic gut
Linwen Huang, Huishi Tan, Senhui Weng, Yuntao Liu, Lingxu Song, Shaoyu Cheng, Zelong Lin, Jiawei Chen, Fei Tan, Jun Wang, Jinke Huang, Linkun Cai, Jiwei Chai, Cailing Zhong, Yanqiang Shi, Wendi Zhang, Haiyan Zhang, Chongyang Huang   +17 more
wiley   +1 more source

Machine Learning the Dark Matter Halo Mass of Milky Way-Like Systems

The Open Journal of Astrophysics
Despite the Milky Way's proximity to us, our knowledge of its dark matter halo is fairly limited, and there is still considerable uncertainty in its halo mass.
Elaheh Hayati, Peter Behroozi, Ekta Patel   +2 more
doaj   +1 more source

Constraining the Tilt of the Milky Way's Dark Matter Halo with the Sagittarius Stream

, 2022
Recent studies have suggested that the Milky Way (MW)'s Dark Matter (DM) halo may be significantly tilted with respect to its central stellar disk, a feature that might be linked to its formation history. In this work, we demonstrate a method of constraining the orientation of the minor axis of the DM halo using the angle and frequency variables.
Panithanpaisal, Nondh, Sanderson, Robyn E., Arora, Arpit, Cunningham, Emily C., Baptista, Jay   +4 more
openaire   +2 more sources

Sex‐Specific Regulation of Glycemic Homeostasis by Theabrownin from Pu‐erh Tea

Advanced Science, EarlyView.
Pu‐erh tea's key component, theabrownin (TB), lowers blood glucose in a sex‐specific manner. In females, estrogen boosts intestinal MUC2 production, which dramatically enhances TB's ability to inhibit the carbohydrate‐digesting enzyme α‐glucosidase.
Yang Li, Junliang Kuang, Dan Zheng, Jieyi Wang, Kun Ge, Chun Qu, Xiaojiao Zheng, Zhenxing Ren, Fengjie Huang, Mingliang Zhao, Yimin Sun, Huiheng Zhang, Keke Ding, Xixi Xia, Yajun Tang, Lu Liu, Jian Zhou, Fei Gao, Xiaohui Ma, Yongquan Xu, Guoxiang Xie, Aihua Zhao, Wei Jia   +22 more
wiley   +1 more source