Results 91 to 100 of about 7,809,762 (287)

Cerium Nanoparticle‐Mediated Inhibition of the NSUN2/m5C Axis Suppresses Synovial Aggression in Rheumatoid Arthritis

Advanced Science, EarlyView.
A novel epitranscriptomic mechanism in rheumatoid arthritis is uncovered: NSUN2 promotes disease via m5C‐dependent stabilization of ICMT mRNA, fueling the migration and invasion of pathogenic RA FLS. Targeting this axis with engineered nanoparticles (Ce/SAA NPs) effectively inhibits disease progression, presenting a precise therapeutic strategy ...
Ruiru Li, Simin Chen, Huijuan Hu, Shiyao Wu, Jingnan Wang, Kai Sun, Chenxi Peng, Suling Liu, Shuoyang Zhang, Yu Kuang, Wei Chen, Qian Qiu, Liuqin Liang, Yu Wen, Hanshi Xu, Youjun Xiao   +15 more
wiley   +1 more source

A $\sim$300 pc-sized core of Milky Way dark matter halo constrained from the OGLE micro-lensing sky map [PDF]

We report the detection of a 282 $^{+34}_{-31}$ pc-sized core in the center of Milky Way dark matter halo at $68\%$ confidence level by using the micro-lensing event rate sky map data from the Optical Gravitational Lensing Experiment (OGLE) survey.
Li, Qinxun, Wei, Leyao, Cai, Yi-Fu, Luo, Wentao, Q. Li, Y. F. Cai, Q. Guo, W. Luo, Lin, Shu-Rui, B. Wang, A. Rodriguez, C. Su, Wang, Bo, L. Wei, S. Lin, Su, Can-Po, Rodriguez, Alexander, Guo, Qi   +17 more
core   +1 more source

Estimating the dark matter halo mass of our Milky Way using dynamical tracers [PDF]

, 2015
The mass of the dark matter halo of the Milky Way can be estimated by fitting analytical models to the phase-space distribution of dynamical tracers.
Han, Jiaxin, Cole, Shaun, Han, J., Cole, S., Lowing, B., Frenk, Carlos, Wang, W., Cooper, A.P., Frenk, C., Wang, Wenting, Cooper, Andrew P., Lowing, Ben   +11 more
core   +1 more source

RPLP2 Mediates the Beneficial Effects of Exercise on Stress Resistance Through Muscle–Brain Communication

Advanced Science, EarlyView.
A novel exercise‐inducible myokine acidic ribosomal protein P2 (RPLP2), initially identified from human trials, is presented here, whose circulating levels negatively correlate with clinical anxiety severity. Muscle‐derived RPLP2 enhances hippocampal ribosomal assembly and adult neurogenesis to rescue stress‐induced anxiety deficits.
Peiyu Luo, Wei Wu, Huan Peng, Dan He, Yuxi Guo, Boyue Zhao, Xiaodan Wang, Li Ma, Yuhang Qin, Yifang Zhai, Lixia Zhuo, Ying Zhang, Yijie Guo, Linlin Jing, Fangyao Chen, Erfei Zhang, Wei Wang, Xiancang Ma, Yan Li   +18 more
wiley   +1 more source

Bar-driven Streaming Motions Mimic a Massive Bulge in the Inner Milky Way

The Astrophysical Journal
The circular speed curve of the Milky Way provides a key constraint on its mass distribution, reflecting the axisymmetric component of the gravitational potential.
Junichi Baba
doaj   +1 more source

The oblateness of the Milky Way dark matter halo from the stellar streams of NGC 3201, M68, and Palomar 5 [PDF]

We explore constraints on the Milky Way dark matter halo oblateness using three stellarstreamsfrom globular clusters NGC3201, M68, and Palomar 5. Previous constraints on the gravitational potential from dynamical equilibrium of stellar populations and ...
Palau, Carles G., Miralda Escudé, Jordi
core   +1 more source

HMGCR‐Driven Cholesterol Metabolism Promotes Osteoarthritis Progression by Accelerating Synovial Fibroblast Senescence

Advanced Science, EarlyView.
In the pathological context of osteoarthritis (OA), the phosphorylation of AKT1 at Ser473 enhances its binding to Lys140 of Insig1, which facilitates the formation of AKT1–Insig1 complex. Subsequently, the activation of AKT1 promotes the phosphorylation of Insig1 at Ser189, potentially enhancing the dissociation of Insig1 from sterol regulatory element‑
Xiaoqi Zhang, Siru Zhou, Xi Liu, Wei Xiang, Xiuqin Peng, Yu Tian, Song Li, Hailin Wang, Bo Liao, Shunzheng Fang, Runze Jin, Jinhui Wu, Chuanqing Bai, Wei Zhang, Bo Huang, Bingfei Li, Lifeng Chen, Lin Chen, Bin Zhang, Zhenhong Ni   +19 more
wiley   +1 more source

A Novel IDO1/NE Dual Inhibitor, IMM‐H018 Prevents the Primary and Secondary Sepsis and Ameliorates the Kidney Injury Through Inhibiting the Cytokine Storm and Microthrombosis, and Reversing Immunosuppression

Advanced Science, EarlyView.
IMM‐H018, a dual IDO1/NE inhibitor, demonstrates potent therapeutic efficacy in sepsis by simultaneously targeting excessive inflammation and immune dysfunction. It prevents both primary and secondary sepsis through anti‐inflammatory, immune‐restoring, and renoprotective mechanisms, reducing organ damage, improving immune homeostasis, preserving kidney
Yi Zhou, Xiaodi Zhao, Xiaochen Pan, Zhiling Ma, Huaqing Cui, Hui Wen, Peng Wang, Xiufeng Liao, Kejie Qin, Yuchen Wang, Li Sheng, Sen Zhang   +11 more
wiley   +1 more source

Importance of Initial Condition on Bar Secular Evolution: Role of Halo Angular Momentum Distribution Discontinuity

The Astrophysical Journal
The dark matter halo properties, for example, mass, spin, and concentration, play a significant role in the formation and evolution of bars in disk galaxies.
Sandeep Kumar Kataria, Juntai Shen
doaj   +1 more source

CALB2 is a Mechanoresistance Gene in Metastatic Prostate Cancer

Advanced Science, EarlyView.
Prostate cancer cell lines of differing origins were cultured over many passages while being subjected to semi‐lethal levels of fluid shear stress, representing the harsh mechanical environment these cells are subjected to in the circulation during the process of distant metastasis.
Abigail R. Fabiano, Allen C. Luo, Paul Taufalele, Jenna A. Dombroski, Ehsan Aalaei, Schyler J. Rowland, Melissa S. Cantú, Alexandria T. Carter, Samantha V. Knoblauch, Cynthia A. Reinhart‐King, Michael R. King   +10 more
wiley   +1 more source