Results 111 to 120 of about 7,809,762 (287)

GD-1 Stellar Stream and Cocoon in the DESI Early Data Release

The Astrophysical Journal
We present  ∼115 new spectroscopically identified members of the GD-1 tidal stream observed with the 5000-fiber Dark Energy Spectroscopic Instrument (DESI).
M. Valluri, P. Fagrelius, S. E. Koposov, T. S. Li, Oleg Y. Gnedin, E. F. Bell, R. G. Carlberg, A. P. Cooper, J. Aguilar, S. Ahlen, C. Allende Prieto, V. Belokurov, L. Beraldo e Silva, D. Brooks, A. Byström, T. Claybaugh, K. Dawson, A. Dey, P. Doel, J. E. Forero-Romero, E. Gaztañaga, S. Gontcho A Gontcho, J. Han, K. Honscheid, T. Kisner, A. Kremin, A. Lambert, M. Landriau, L. Le Guillou, M. E. Levi, A. de la Macorra, M. Manera, P. Martini, G. E. Medina, A. Meisner, R. Miquel, J. Moustakas, A. D. Myers, J. Najita, C. Poppett, F. Prada, M. Rezaie, G. Rossi, A. H. Riley, E. Sanchez, D. Schlegel, M. Schubnell, D. Sprayberry, G. Tarlé, G. Thomas, B. A. Weaver, R. H. Wechsler, R. Zhou, H. Zou   +53 more
doaj   +1 more source

Aberrant GRP78 Phase Transition Sustains Endothelial IRE1α Signaling and Drives Blood–Brain Barrier Failure in Cerebral Amyloid Angiopathy

Advanced Science, EarlyView.
Vascular Aβ40 corrupts GRP78 phase behavior in brain endothelial cells, sustaining IRE1α–TRAF2–JNK signaling and driving apoptosis, tight junction loss, and blood–brain barrier failure in cerebral amyloid angiopathy. Pharmacological IRE1α inhibition restores vascular integrity, reduces leakage, and improves functional outcomes, revealing a targetable ...
Honglin Zheng, Qiang Li, Haiyang Luo, Yapei Yuan, Na Zhang, Yongting Lu, Suying Duan, Jieshi Zhong, Hang Zhang, Chenyang Liu, Yaochong Zhang, Wenzhuo Zhao, Yaxuan Song, Tuo Wang, Si Yan, Yapeng Li, Han Liu, Yuan Gao, Zongping Xia, Yuming Xu   +19 more
wiley   +1 more source

A Unified Halo Mass Function Across Dark Matter Models from High-Resolution Multi-Scale Simulations

The Open Journal of Astrophysics
We measure the dark matter halo mass function, with backsplash halos removed, from a wide range of cosmological-box and zoom-in simulations. These include the MultiDark Planck boxes, along with a suite of zoom-in simulations of Group, Milky Way, and LMC ...
Andrew Benson, Ethan O. Nadler, Xiaolong Du, Vera Gluscevic   +3 more
doaj   +1 more source

Targeting the KCNC3‐Dependent Anterior Insular‐Lateral Orbitofrontal Cortex Glutamatergic Circuit Attenuates Post‐Traumatic Anxiety

Advanced Science, EarlyView.
Frontal lobe traumatic brain injury is associated with hyperactivity of an insular–orbitofrontal circuit in both patients and mice. By combination of integrating functional imaging, cell‐type–specific circuit manipulation, single‐cell transcriptomics, and whole‐cell recordings, this work identifies the downregulation of the potassium channel KCNC3 in ...
Meng‐Ge Li, Xiao‐Bo Qian, Hai‐Long Zhang, Di Li, Ling Ji, Xin‐Chun Xu, Jia‐Sheng Ding, Li‐Jun Yin, Li Zhang, Guang‐Yin Xu, Rong Gao   +10 more
wiley   +1 more source

AI Designed Conformation Locking Peptides Target STING to Restore Diabetic Wound Healing

Advanced Science, EarlyView.
A generative AI pipeline identifies SCP‐1, a conformation‐locking peptide that stabilizes inactive STING. Incorporated into a dual‐responsive hydrogel for localized, MMP‐9‐triggered release, SCP‐1 suppresses inflammation, promotes reparative macrophage polarization, and accelerates diabetic wound healing.
Xinyu Li, Haojie Fu, Zhe Wang, Xuanzhou Chen, Ruhong Zhang, Xudong Wang, Louis D. Zhang, Xiang Li, Datao Li   +8 more
wiley   +1 more source

Milky Way-est: Cosmological Zoom-in Simulations with Large Magellanic Cloud and Gaia–Sausage–Enceladus Analogs

The Astrophysical Journal
We present Milky Way-est, a suite of 20 cosmological cold-dark-matter-only zoom-in simulations of Milky Way (MW)-like host halos. Milky Way-est hosts are selected such that they (i) are consistent with the MW’s measured halo mass and concentration, (ii ...
Deveshi Buch, Ethan O. Nadler, Risa H. Wechsler, Yao-Yuan Mao   +3 more
doaj   +1 more source

Predicting the XRISM dark matter decay signal in the Milky Way halo [PDF]

Dark matter may be detected in X-ray decay, including from the decay of the dark matter particles that make up the Milky Way (MW) halo. We use a range of density profiles to compute X-ray line intensity profiles, with a focus on the resonantly produced ...
Lovell, M R
core   +1 more source

Reorganization of Innate Immune Cell Lipid Profiles by Bioinspired Meroterpenoids to Limit Inflammation

Advanced Science, EarlyView.
Resolution pharmacology is an emerging strategy to tackle inflammatory pathologies. Bioinspired meroterpenoids induce a lipid mediator class switch toward inflammation resolution in vitro and in vivo by targeting key nodes in lipid mediator biosynthesis and neutral lipid dynamics.
Lorenz Waltl, David Holubek, Klaus Speck, Raphael Wildermuth, Franz‐Lucas Haut, Stephan Permann, Immanuel Plangger, Christian Steinborn, Zhigang Rao, Danilo D'Avino, Ida Cerqua, Julia Stadler, Fiorentina Roviezzo, Peter Schlenke, Anita Siller, Harald Schennach, Solveigh C. Koeberle, Eva‐Maria Pferschy‐Wenzig, Antonietta Rossi, Thomas Magauer, Andreas Koeberle   +20 more
wiley   +1 more source

C-19 and Hot, Wide Star Streams

The Astrophysical Journal
The C-19 star stream has the abundance characteristics of an unusually metal-poor globular cluster but kinematically is uncharacteristically hot and wide for a cluster stream, having a line-of-sight velocity dispersion of 7  ±  2 km s ^−1 and a 1 σ width
Raymond G. Carlberg, Rodrigo Ibata, Nicolas F. Martin, Else Starkenburg, David S. Aguado, Khyati Malhan, Kim Venn, Zhen Yuan   +7 more
doaj   +1 more source

The oblateness of the Milky Way dark matter halo from the stellar streams of NGC 3201, M68, and Palomar 5

, 2022
We explore constraints on the oblateness of the Milky Way dark matter halo inferred from fits to three stellar streams generated by the globular clusters NGC 3201, M68 (NGC 4590), and Palomar 5.
Palau, Carles G., Miralda-Escudé, Jordi
core