Results 131 to 140 of about 7,809,762 (287)

TRIM28‐Derived Peptide Exerts Anti‐Tumor Roles by Stabilizing Tumor Suppressive BRD7 Protein in Multiple Cancers

Advanced Science, EarlyView.
An α‐helical peptide, TAB12, designed to mimic the TRIM28 binding interface, competitively disrupts the TRIM28‐BRD7 interaction, thereby blocking ubiquitin‐mediated degradation of the tumor suppressor BRD7. This stabilization unleashes potent anti‐tumor effects across multiple tumor types with a favorable safety profile, offering a feasible strategy ...
Qingqing Wei, Changning Xue, Mengna Li, Jianxia Wei, Lemei Zheng, Shipeng Chen, Yijie Wang, Yumei Duan, Yanwei Luo, Wei Xiong, Ming Zhou   +10 more
wiley   +1 more source

Machine Learning the Dark Matter Halo Mass of the Milky Way

Although numerous dynamical techniques have been developed to estimate the total dark matter halo mass of the Milky Way, it remains poorly constrained, with typical systematic uncertainties of 0.3 dex. In this study, we apply a neural network-based approach that achieves high mass precision without several limitations that have affected past approaches;
Hayati, Elaheh, Behroozi, Peter, Patel, Ekta, Wang, Yunchong, Gottlöber, Stefan, Yepes, Gustavo   +5 more
openaire   +2 more sources

A Decoy‐Receptor‐Armed Biomimetic Nanotherapeutic With Inherent Tropism for Conserved Pathogenic Macrophages for Treating Osteoarthritis and Intervertebral Disc Degeneration

Advanced Science, EarlyView.
A biomimetic doppelgänger nanosystem neutralizes extracellular inflammatory cytokines and silences intracellular pyroptosis, reprogramming pathogenic macrophages to attenuate both joint and spine degeneration. ABSTRACT Osteoarthritis (OA) and intervertebral disc degeneration (IVDD) are debilitating musculoskeletal disorders driven by shared ...
Fudong Li, Bin Zhang, Zhiqiu Zhang, Bing Zheng, Linhui Han, Chen Yan, Jialin Li, Kaiqiang Sun, Tianyi Zhao, Jiangang Shi   +9 more
wiley   +1 more source

Star Stream Velocity Distributions in Cold Dark Matter and Warm Dark Matter Galactic Halos

The Astrophysical Journal
The dark matter subhalos orbiting in a galactic halo perturb the orbits of stars in thin stellar streams. Over time, the random velocities in the streams develop non-Gaussian wings.
Raymond G. Carlberg, Adrian Jenkins, Carlos S. Frenk, Andrew P. Cooper   +3 more
doaj   +1 more source

Iron‐Tannic Acid Hydrogel Mediated Mild Photothermal Therapy Combined With Ferroptosis Enhances Anti‐Tumor Immunity in Colorectal Cancer

Advanced Science, EarlyView.
An injectable gelatin‐based tannic acid–iron hydrogel with mild photothermal therapy could not only induce immunogenic cell death, but also elicit ferroptosis of both tumor cells and tumor‐associated macrophages, resulting in DC maturation, T‐cell infiltration and down‐regulation of ferroptosis‐sensitive M2‐type TAMs levels.
Yuan Zhu, Xi Yu, Tao Wang, Wanyi Liu, Chang Lu, Jiani Zhong, Yujie He, Wei Li, Kunxi Zhang, Peihao Yin, Zeting Yuan   +10 more
wiley   +1 more source

An Effector TaCRVP From Tuta Absoluta Oral Secretion Impairs H2O2‐Mediated Plant Defense by Targeting Tomato SlCAT2

Advanced Science, EarlyView.
The Tuta absoluta salivary effector TaCRVP subverts tomato immunity by hijacking host catalase SlCAT2. Through a sophisticated dual mechanism, TaCRVP simultaneously promotes SlCAT2 tetramerization for activation and blocks its SlAdBiL‐mediated degradation for stabilization.
Jianquan Yan, Youdan Zhang, Zhujun Wang, Huatao Tang, Huiping Liu, Zi Chen, Shuai Liu, Jiayi Shi, Lu Peng, Youming Hou   +9 more
wiley   +1 more source

Dark matter constraints from wide halo binary stars

, 2010
We report on a recent re-examination of dark matter constraints from halo wide stellar binaries, motivated by observations we made of four of the very wide binary candidates on which earlier constraints were based.
Koch, Andreas, Wilkinson, M. I., Irwin, Michael J., Marshall, J., Belokurov, V., Quinn, D. P.   +5 more
core   +4 more sources

Microlensing Optical Depth, Event Rate, and Limits on Compact Objects in Dark Matter Based on 20 Yr of OGLE Observations of the Small Magellanic Cloud

The Astrophysical Journal Supplement Series
Some previous studies have suggested that massive and intermediate-mass primordial black holes (PBHs) could comprise a substantial fraction of dark matter in the Universe.
Przemek Mróz, Andrzej Udalski, Michał K. Szymański, Igor Soszyński, Paweł Pietrukowicz, Szymon Kozłowski, Radosław Poleski, Jan Skowron, Dorota Skowron, Krzysztof Ulaczyk, Mariusz Gromadzki, Krzysztof Rybicki, Patryk Iwanek, Marcin Wrona, Milena Ratajczak   +14 more
doaj   +1 more source

The Flattened Dark Matter Halos of NGC 4244 and the Milky Way

, 1996
10 pages, including 4 figures. Total 230 kByte. Requires the Sprocl.sty file (can be found at:http://www.wspc.co.uk) To appear in the proceedings of ``Aspects of Dark Matter in Astro- and Particle Physics'', Heidelberg, September 1996 (World Scientific: Eds. H.V. Klapdor-Kleingrothaus, Y. Ramachers)
openaire   +2 more sources

ZBTB18 Dysfunction Promotes Neuropathic Pain via CHD4‐based Epigenetic Disinhibition of CLIC1 Channels in Sensory Neurons

Advanced Science, EarlyView.
In this study, we identify a novel functional role of ZBTB18 in regulating trigeminal‐mediated neuropathic pain. Nerve injury reduces ZBTB18 in trigeminal ganglion neurons, impairing CHD4/NuRD recruitment and de‐repressing Clic1. Elevated CLIC1 enhances chloride channel activity and neuronal hyperexcitability, thereby driving pain.
Shoupeng Wang, Zitong Huang, Yu Tao, Yunmei Zhang, Yufang Sun, Dongsheng Jiang, Weiwei Lu, Fuhai Ji, Gang Chen, Min Xu, Yuan Zhang, Jin Tao   +11 more
wiley   +1 more source