Results 151 to 160 of about 7,809,762 (287)

Phase Separation of SF3B1 Serves as a Critical Post‐Transcriptional Regulator During Early Mouse Embryogenesis

Advanced Science, EarlyView.
Phase separation of SF3B1 acts as a key regulatory mechanism for dynamic alternative splicing throughout early mouse embryogenesis. Its absence triggers extensive splicing errors, which induce persistent DNA damage, defective cell cycle progression, and failed cell lineage commitment, and ultimately hinder the normal growth and development of ...
Kang Zhao, Ting‐Yu Han, Yan‐Li Cheng, Yi‐Dan Zhang, Yu‐Wei Zhang, JinJian Guo, ShaoJun Zhang, WenZe Huang, Jing Zhang, Pei‐Yu Liao, Ying Xin, ChuanChen Chu, Qing‐Yuan Sun, ZhiZhen Liu, Xiang‐Hong Ou, Jun Xie   +15 more
wiley   +1 more source

Robust Measurement of Stellar Streams around the Milky Way: Correcting Spatially Variable Observational Selection Effects in Optical Imaging Surveys

The Astrophysical Journal
Observations of density variations in stellar streams are a promising probe of low-mass dark matter substructure in the Milky Way. However, survey systematics such as variations in seeing and sky brightness can also induce artificial fluctuations in the ...
K.K. Boone, P.S. Ferguson, M. Tabbutt, K. Bechtol, T.-Y. Cheng, A. Drlica-Wagner, C. E. Martínez-Vázquez, B. Mutlu-Pakdil, T. M. C. Abbott, M. Aguena, O. Alves, F. Andrade-Oliveira, D. Bacon, S. Bocquet, D. Brooks, R. Camilleri, A. Carnero Rosell, L. N. da Costa, M. E. da Silva Pereira, T. M. Davis, J. De Vicente, S. Desai, P. Doel, S. Everett, B. Flaugher, J. Frieman, J. García-Bellido, D. Gruen, G. Gutierrez, S. R. Hinton, D. L. Hollowood, K. Honscheid, D. J. James, K. Kuehn, J. L. Marshall, J. Mena-Fernández, F. Menanteau, R. Miquel, J. Myles, R. L. C. Ogando, A. A. Plazas Malagón, A. Porredon, M. Rodríguez-Monroy, E. Sanchez, D. Sanchez Cid, I. Sevilla-Noarbe, M. Smith, E. Suchyta, M. E. C. Swanson, V. Vikram, N. Weaverdyck, (DES Collaboration)   +51 more
doaj   +1 more source

Engineered Transformer Base Editor with Enhanced Editing Efficiency

Advanced Science, EarlyView.
A highly efficient transformer base editor system achieves robust genomic editing in a humanized mouse model. This work establishes a versatile and translatable platform, opening new avenues for precision gene therapy. ABSTRACT Canonical cytosine base editors (CBEs) achieve precise C‐to‐T conversions without inducing DNA double‐strand breaks (DSBs ...
Bowen Chen, Letong Liang, Rui Xu, Tianyi Wang, Hongyan Chen, Daru Lu   +5 more
wiley   +1 more source

A Model-independent Radio Telescope Dark Matter Search in the L and S Bands

The Astrophysical Journal Letters
Ultralight bosonic dark matter in its most general form can be detected through its decay or annihilation to a quasimonochromatic radio line. Assuming only that this line is consistent with the most general properties of the expected phase space of our ...
Aya Keller, Nicole Wolff, Karl van Bibber   +2 more
doaj   +1 more source

Geometry of the Milky Way’s dark matter from dynamical models of the tilted stellar halo

Monthly Notices of the Royal Astronomical Society
ABSTRACT The shape and orientation of the Milky Way’s dark matter halo remain poorly constrained. Observations of the accreted stellar halo show that it is triaxial and tilted with respect to the disc. If this configuration is long-lived, it can place constraints on the shape and orientation of the dark matter halo that can support it
Adam M Dillamore, Jason L Sanders
openaire   +2 more sources

Spatiotemporally Controlled Sequential Chemo‐Immunotherapy Activates Pyroptosis for Robust Anti‐Tumor Immunotherapy

Advanced Science, EarlyView.
A glutathione and ultrasound dual‐responsive cerasome achieves sequential co‐delivery of gemcitabine and BMS1166 in tumors. Chemotherapy priming followed by on‐demand PD‐L1 blockade synergistically amplifies anti‐tumor immunity, inhibiting primary tumor growth, distant metastasis and inducing durable immune memory.
Suhui Sun, Ruiqi Wu, Qingshuang Tang, Yunli Xu, Wanrui Shi, Mengxin Wang, Haonan Wang, Yan Luo, Cheng Ma, Xiaolong Liang   +9 more
wiley   +1 more source

Millimeter-wave CO and SiO Observations toward the Broad-velocity-width Molecular Feature CO 16.134–0.553: A Smith Cloud Scenario?

The Astrophysical Journal
We report the results of the CO J = 1–0 and SiO J = 2–1 mapping observations toward the broad-velocity-width molecular feature (BVF) CO 16.134–0.553 with the Nobeyama Radio Observatory 45 m telescope.
Hiroki Yokozuka, Tomoharu Oka, Shiho Tsujimoto, Yuto Watanabe, Miyuki Kaneko   +4 more
doaj   +1 more source

Structural Basis of Lymphangiogenic Receptor VEGFR‐3 Activation Mediated by Distinctive Clustering of the Ligand–Receptor Complex

Advanced Science, EarlyView.
VEGF‐C and its receptor VEGFR‐3 are critical for lymphangiogenesis. Cryo‐EM structures of the VEGFR‐3/VEGF‐C ectodomain complex reveal a canonical 2:2 ligand–receptor hetero‐tetramer that further assembles into higher‐order clusters beyond simple receptor dimerization.
Ryeongeun Cho, Jinsook Ahn, Jimin Yang, Dong Sun Lee, Gahi Hong, Sangkyu Lee, Ho Min Kim   +6 more
wiley   +1 more source

Molecular Atlas of Key Food Odorants Reveals Mixture‐Level Organization and Enables Generative Aroma Design

Advanced Science, EarlyView.
KFO‐Atlas reveals how real‐world aromas are organized as structured mixtures rather than individual molecules. Building on these principles, KFO‐Gen, a generative AI framework, designs perceptually valid aroma formulations and reconstructs meat‐like aromas exclusively from plant‐derived odorants, providing a foundation for mixture‐level studies and AI ...
Jingzhi Zhang, Huadong Xing, Antonella Di Pizio, Qinfei Ke, Xingran Kou, Dachuan Zhang   +5 more
wiley   +1 more source

Fuzzy Dark Matter and the Impact of Core–Halo Diversity on Its Particle Mass Constraints

The Astrophysical Journal
We investigate how diversity in the core–halo mass relation and the inclusion of higher-order velocity moments affect constraints on the fuzzy dark matter particle mass ( m _ψ ) inferred from the internal kinematics of dwarf galaxies.
Dafa Wardana, Kohei Hayashi, Masashi Chiba, Elisa G. M. Ferreira   +3 more
doaj   +1 more source