Results 161 to 170 of about 7,809,762 (287)

DDX21 Enhances Radiosensitivity in Head and Neck Squamous Cell Carcinoma by Suppressing MK2‐Mediated DNA Damage Response

Advanced Science, EarlyView.
DDX21 suppresses MK2 activation by directly inhibiting Thr334 phosphorylation in a p38‐independent manner, thereby impairing DNA damage response. Clinically, patients with well‐differentiated tumors exhibiting high DDX21 expression are more likely to benefit from adjuvant radiotherapy, whereas those with low DDX21 levels are predisposed to ...
Tianru Yang, Ting Shen, Yanfang Qiu, Wei Zhang, Ziran Zheng, Jiayi Sun, Yuedi Yao, Mianfeng Yao, Jiang Li   +8 more
wiley   +1 more source

COZMIC. II. Cosmological Zoom-in Simulations with Fractional non-CDM Initial Conditions

The Astrophysical Journal
We present 24 cosmological dark matter (DM)-only zoom-in simulations of a Milky Way analog with initial conditions appropriate for scenarios where non-cold dark matter (NCDM) is a fraction of the total DM abundance (f-NCDM models) as the second ...
Rui An, Ethan O. Nadler, Andrew Benson, Vera Gluscevic   +3 more
doaj   +1 more source

Sonogenetics Nanomedicine Activates the cGAS‐STING Pathway for Immunotherapy of Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
A HER3‐targeted sonogenetic lipid nanoparticle platform is developed for triple‐negative breast cancer therapy. An AI‐designed miniprotein inhibits HER3 signaling, while TRPV4 and NFAT‐responsive IL‐15 plasmids enable ultrasound‐controlled calcium signaling and cytokine expression. The system induces Ca2+ overload, ROS generation, mitochondrial damage,
Junya Song, Yan Liu, Shifeng Zhao, Cheng Zhu, Hongchang Guo, Jin Chang, Jun Kang   +6 more
wiley   +1 more source

GD-1 and the Milky Way Starless Dark Matter Subhalos

The Astrophysical Journal
Measurements of the GD-1 star stream velocity distribution within ±3° of the centerline find a total line-of-sight velocity spread of 5–6 km s ^−1 in the-well measured ϕ _1  = [−30, 0] region.
Raymond G. Carlberg
doaj   +1 more source

Fermentation Potentials of Baobab Pulp Extract in Soy Yoghurt Production

AgriFood: Journal of Agricultural Products for Food, EarlyView.
The research work was about the importance of sourcing for alternative inoculants to replace the main inoculants regularly used for yoghurt production. The search for baobab pulp extract as replacement yielded result, as soy yoghurt was successfully produced.
Adegbola Oladele Dauda, Nahim Mokolade Adeagbo, Quadri Idowu Akinremi, Taofiqat Damilola Maiyaki, Adedamola Israel Abioye, Zulfiqoh Tolani AbdulAkeem, Damilare Johnson Folaranmi   +6 more
wiley   +1 more source

Adipose‐derived mesenchymal stem cell injection into the KI10 acupoint mitigates cartilage damage in KOA rats through PGE2‐mediated α7nAChR/NF‐κB pathway

Animal Models and Experimental Medicine, EarlyView.
In our research, KOA rat models were established and treated with ADSC injection into the KI10 acupoint. Pain relief, behavioral function, and joint structural improvements were systematically assessed using ethological tests, imaging, histopathological staining, transmission electron microscopy, and molecular analyses.
Mengwei Dong, Wenfang Li, Wanpeng Yang, Te Ba, Nan Nan, Yang Liu, Jing Han, Huiqin Hao   +7 more
wiley   +1 more source

Dynamics of Axion Clumps in the Milky Way halo to study Dark Matter

, 2022
In a wide variety of axion models, a relevant fraction of all Dark Matter (DM) is expected to bound in dense small-scale substructures, called axion miniclusters. Despite they enhance the local DM density, the crossing of miniclusters through Earth are rare events occurring once in 105 years making direct detection inefficient.
openaire   +1 more source

Performance Assessment and Lab‐Scale Economic Evaluation of Alkaline Extraction and Comparative Precipitation of Cyanobacterial Proteins

Asia-Pacific Journal of Chemical Engineering, EarlyView.
ABSTRACT Algal proteins from cyanobacteria serve as a natural source of biopolymers. The principal challenge manifests as nonoptimization of unit operations in downstream process accounting for higher costs. This study focuses on process assessment of unit‐operations for selecting suitable recovery strategies not only based on yield, but also considers
Neha Goel, Ariz Hussain, Poonam Choudhary   +2 more
wiley   +1 more source

Entropy of the Universe and Hierarchical Dark Matter. [PDF]

Entropy (Basel), 2022
Frampton PH.
europepmc   +1 more source

Mapping Lupinus polyphyllus density and distribution along road verges using unmanned aerial vehicle (UAV)–based remote sensing

Applications in Plant Sciences, EarlyView.
Abstract Premise Road verges function as refuges for semi‐natural species, but they can also facilitate the spread of non‐native plants such as Lupinus polyphyllus. Unmanned aerial vehicle (UAV)–based remote sensing is a promising tool for mapping these species; however, its application in roadside contexts remains limited.
Elin L. Blomqvist, Jan‐Olov Andersson, R. Lutz Eckstein, Jan Haas   +3 more
wiley   +1 more source