Results 141 to 150 of about 7,809,762 (287)

Cosmological Predictions for Minor Axis Stellar Density Profiles in the Inner Regions of Milky Way–mass Galaxies

The Astrophysical Journal
ΛCDM cosmology predicts the hierarchical formation of galaxies, which build up mass by merger events and accreting smaller systems. The stellar halo of the Milky Way (MW) has proven to be useful a tool for tracing this accretion history. However, most of
Madeline Lucey, Robyn E. Sanderson, Danny Horta, Aritra Kundu, Philip F. Hopkins, Arpit Arora, Jasjeev Singh, Nondh Panithanpaisal   +7 more
doaj   +1 more source

The Adipose‐Sympathetic Nerve Crosstalk: FSTL1 as an Adipocyte‐Derived Neurotrophic Factor for WAT Browning

Advanced Science, EarlyView.
As a novel adipose‐derived neurotrophic factor, Follistatin‐like 1 is endocytosed by sympathetic neurons primarily via tropomyosin‐related kinase B. This process promotes sympathetic innervation in adipose tissue and norepinephrine release, leading to white adipose tissue browning, enhanced thermogenesis, and anti‐obesity effects in mice.
Xiao‐Wei Jia, Jia‐Xin Liu, Rui‐Ping Wang, Xue‐Qin Wu, Yao Che, Mu‐Chen Wu, Hong‐Wei Shang, Xin Lu, Tao Lu, Lu‐Lu Wang, Chun‐Yan Jiang, Dong‐Liang Fang, Chun Yang, Yan Gao   +13 more
wiley   +1 more source

Multi‐Technique Integration Identifies O‐GlcNAc Transferase in Fibroblast‐Like Synoviocytes as a Therapeutic Target for Rheumatoid Arthritis

Advanced Science, EarlyView.
AI‑guided single‑cell transcriptomics identifies OGT as a key regulator enriched in rheumatoid arthritis fibroblast‑like synoviocytes (RA‐FLSs). Inflammatory stimuli activate the OGT–SAP130 axis, which modulates the H3K27ac/H3K27me3 balance and epigenetically silences BTG2, promoting aggressive transformation of RA‑FLSs.
Duoli Xie, Jie Huang, Chunhao Cao, Zhenchao Tang, Xingchen Li, Jianmin Guo, Xinxin Chen, Fang Wang, Dongyi He, Jie Li, Yu Du, Bing He, Jianhua Yao, Aiping Lu, Chao Liang   +14 more
wiley   +1 more source

Spatiotemporal Multi‐Omic Mapping Reveals Liver‐Muscle Metabolic Crosstalk in Cancer Cachexia

Advanced Science, EarlyView.
The interactive CCAtlas platform delineates cross‐species, spatiotemporal, and sex‐specific molecular dynamics and metabolic rewiring across organs during cancer cachexia. Hepatic Gamt downregulation curtails hepatic creatine synthesis to trigger systemic creatine insufficiency and consequent skeletal muscle atrophy in LLC tumour‐bearing mice ...
Zihan Tian, Qianyu Wang, Wenyan Gao, Xianfeng Li, Jiawen Fan, Xiaoliang Wu, Siqi Liu, Xiangdong Ming, Danna Yeerken, Mutian Shen, Qingjie Min, Qimin Zhan, Yan Wang   +12 more
wiley   +1 more source

Decoding the Galactic Twirl: The Downfall of Milky Way–Mass Galaxy Rotation Curves in the FIRE Simulations

The Astrophysical Journal
Recent measurements of the Milky Way rotation curve found a sharp decline at around 15–20 kpc from the center of the Galaxy, suggesting that the Galactic dark matter halo is much less massive than predicted by other dynamical tracers.
Xiaowei Ou, Lina Necib, Andrew Wetzel, Anna Frebel, Jeremy Bailin, Micah Oeur   +5 more
doaj   +1 more source

There's no place like home? Statistics of Milky Way-mass dark matter halos

, 2009
We present an analysis of the distribution of structural properties for Milky Way-mass halos in the Millennium-II Simulation (MS-II). This simulation of structure formation within the standard LCDM cosmology contains thousands of Milky Way-mass halos and has sufficient resolution to properly resolve many subhalos per host.
Boylan-Kolchin, M., Springel, V., White, S., Jenkins, A.   +3 more
openaire   +3 more sources

Dark matter substructure in the Milky Way

The standard Lambda-CDM cosmological model predicts a wealth of small-scale structures, including dark matter subhalos residing within more massive halos such as that of our own Milky Way galaxy. While some of these subhalos may be massive enough to host
Kong, Hyunsu
core   +1 more source

AHR‐Responsive Carbon Dots Orchestrate Skin Wound Healing and Colonic Mucosal Repair via Treg‐Mediated Macrophage Efferocytosis

Advanced Science, EarlyView.
Guided by pharmacophore modeling and molecular docking, aryl hydrocarbon receptor (AHR)‐responsive carbon dots were synthesized. They bind directly to AHR and expand gut‐resident regulatory T (Treg) cells. Treg‐derived C‐C motif chemokine ligand 1 (CCL1) enhances macrophage efferocytosis, creating a pro‐regenetative niche that promotes colonic mucosal ...
Zilu Zhu, Han Zhang, Shuai Lin, Wenqian Zheng, Xin Li, Xiaowei Xu, Ruili Yang   +6 more
wiley   +1 more source

Transient Sleep Deprivation Induces Persistent Auditory Neuropathy via ROS‐Initiated Neuroinflammation and BK Channel Suppression

Advanced Science, EarlyView.
Sleep disturbance severity closely tracks hearing loss in a clinical cohort, yet the mechanistic link remains unclear. Acute sleep deprivation is shown to trigger transient cochlear oxidative stress that switches into a self‐sustaining neuroinflammatory state, suppressing BK channels and causing irreversible synaptopathy.
Dan Chen, Ying Ma, Lixuan Huang, Xin Chen, Fanliang Kong, Zhenzhou Qian, Mingyue Guan, Xinlin Wang, Yanyan Yang, Shasha Zhang, Peng Li, Renjie Chai   +11 more
wiley   +1 more source

Diffuse Light in Milky Way–like Haloes

The Astrophysical Journal Letters
We investigate the diffuse light (DL) content of dark matter haloes in the mass range $11.5\leqslant \mathrm{log}{M}_{\mathrm{halo}}\leqslant 13$ , a range that also includes the dark matter halo of the Milky Way, taking advantage of a state-of-the-art ...
Emanuele Contini, San Han, Seyoung Jeon, Jinsu Rhee, Sukyoung K. Yi   +4 more
doaj   +1 more source