Results 121 to 130 of about 7,809,762 (287)

UFL1‐Mediated UFMylation of ENO1 Restrains Aerobic Glycolysis and Colorectal Cancer Progression

Advanced Science, EarlyView.
UFMylation restrains aerobic glycolysis and colorectal cancer progression by modifying the glycolytic enzyme ENO1. Pharmacological enhancement of the UFL1–ENO1 interaction by the FDA‐approved antibiotic torezolid promotes ENO1 UFMylation, suppresses tumor metabolism, and sensitizes colorectal cancer to chemotherapy, revealing an actionable metabolic ...
Xiuqing Ma, Rui Wan, Yueyuan Zhong, Ziyang Cui, Xuan Zhang, Xiaoqiang He, Rong Wang, Lei Huang, Wan‐Yang Sun, Rong‐Rong He, Yang Zhou, Jianshuang Li, Li Shen, Shao‐Hua Wang, Tongzheng Liu   +14 more
wiley   +1 more source

The Distant Milky Way Halo from the Southern Hemisphere: Characterization of the LMC-induced Dynamical Friction Wake

The Astrophysical Journal
The infall of the Large Magellanic Cloud (LMC) into the Milky Way’s halo impacts the distribution of stars and dark matter (DM) in our Galaxy. Mapping the observational consequences of this encounter can inform us about the properties of both galaxies ...
Manuel Cavieres, Julio Chanamé, Camila Navarrete, Yasna Ordenes-Briceño, Nicolás Garavito-Camargo, Gurtina Besla, Maren Hempel, A. Katherina Vivas, Facundo Gómez   +8 more
doaj   +1 more source

Disk Heating, Galactoseismology, and the Formation of Stellar Halos

Galaxies, 2017
Deep photometric surveys of the Milky Way have revealed diffuse structures encircling our Galaxy far beyond the “classical” limits of the stellar disk. This paper reviews results from our own and other observational programs, which together suggest that,
Kathryn V. Johnston, Adrian M. Price-Whelan, Maria Bergemann, Chervin Laporte, Ting S. Li, Allyson A. Sheffield, Steven R. Majewski, Rachael S. Beaton, Branimir Sesar, Sanjib Sharma   +9 more
doaj   +1 more source

Dark matter in the Milky Way

, 2007
Context.Gas within a galaxy is forced to establish pressure balance against gravitational forces. The shape of an unperturbed gaseous disk can be used to constrain dark matter models.
P. M. W. Kalberla, L. Dedes, J. Kerp, U. Haud   +3 more
core   +1 more source

Targeting Tex10 Overcomes Oxaliplatin Resistance by Competitively Disrupting the Non‐Canonical BAF Complex in Colorectal Cancer

Advanced Science, EarlyView.
This study reveals that Tex10 drives oxaliplatin resistance in colorectal cancer by competitively binding BRD9 to disrupt the ncBAF complex, thereby suppressing AMBRA1 transcription and ULK1‐mediated autophagy. Gemcitabine is identified as a direct Tex10 inhibitor that restores autophagy and overcomes resistance.
Ping Xu, Jie Huang, Xiaojin Gao, Lin Deng, Yanheng Deng, Denglu Wang, Chunlei Yu, Yunxiang Zhang, Jingdong Li, Xiaocong Xiang   +9 more
wiley   +1 more source

Dwarf Cosmology with the Stromlo Missing Satellites Survey

Advances in Astronomy, 2010
The standard Lambda Cold Dark Matter model is considered to be a triumph of theoretical astrophysics but observations of the Milky Way and its system of satellite galaxies irresistibly signal that theory is incomplete on galactic and subgalactic scales ...
Helmut Jerjen
doaj   +1 more source

The formation of satellite galaxies and their associated black holes [PDF]

, 2006
Not ...
Libeskind, Noam Isaac
core  

SDF‐1 Attenuates Oocyte Quality Decline During Reproductive Aging Through Autophagy‐Enhanced Stress Granule Scavenging

Advanced Science, EarlyView.
SDF‐1 levels decline significantly with maternal aging. Exogenous supplementation restores meiotic spindle morphology, chromosomal alignment, and mitochondrial function while reducing oxidative stress in aged oocytes. Mechanistically, SDF‐1 enhances autophagic activity to clear accumulated stress granules, thereby rescuing fertilization competence and ...
Rui Long, Meng Wang, Ruolin Mao, Hong Chen, Juepu Zhou, Xiangfei Wang, Zheng Yuan, Ri‐Cheng Chian, Nan Xiao, Qingsong Xi, Yimin Shu, Lei Jin, Lixia Zhu   +12 more
wiley   +1 more source

Effects of Dark Matter Self-interactions on Sagittarius and its Stream

The Astrophysical Journal
This work explores how assumptions regarding the particle-physics nature of dark matter can alter the evolution of the Sagittarius (Sgr) dwarf spheroidal galaxy and its expansive stellar stream.
Connor Hainje, Oren Slone, Mariangela Lisanti, Denis Erkal   +3 more
doaj   +1 more source

The Milky Way Tomography with SDSS. V. Mapping the Dark Matter Halo

, 2014
We present robust constraints from the Sloan Digital Sky Survey (SDSS) on the shape and distribution of the dark matter halo within the Milky Way (MW). Using the number density distribution and kinematics of SDSS halo stars, we probe the dark matter distribution to heliocentric distances exceeding 10 kpc and galactocentric distances exceeding 20 kpc ...
Loebman, Sarah R., Ivezic, Zeljko, Quinn, Thomas R., Bovy, Jo, Christensen, Charlotte R., Juric, Mario, Roskar, Rok, Brooks, Alyson M., Governato, Fabio   +8 more
openaire   +2 more sources