Results 151 to 160 of about 577,018 (252)

The Placenta Regulates Intrauterine Fetal Growth via Exosomal PPARγ

Advanced Science, EarlyView.
The placenta expresses much higher levels of PPARγ than fetal adipose tissue. Trophoblastic exosomes transport PPARγ into fetal preadipocytes via fetoplacental circulation and thus regulate adipogenic genes distinct from endogenous PPARγ. Compromised placental PPARγ leads to fetal adipogenesis deficiency and intrauterine growth restriction, reversible ...
Xiaofang Luo, Biao Huang, Ping Xu, Hao Wang, Baozhen Zhang, Li Lin, Jiujiang Liao, Mingyu Hu, Xiyao Liu, Jiayu Huang, Yong Fu, Mark D. Kilby, Rodney E. Kellems, Xiujun Fan, Yang Xia, Philip N. Baker, Hongbo Qi, Chao Tong   +17 more
wiley   +1 more source

Predicting Interstellar Object Chemodynamics with Gaia

The Astronomical Journal
The interstellar object (ISO) population of the Milky Way is a product of its stars. However, what is in fact a complex structure in the solar neighborhood has traditionally in ISO studies been described as smoothly distributed.
Matthew J. Hopkins, Michele T. Bannister, Chris Lintott   +2 more
doaj   +1 more source

The Inconsistency of Superfluid Dark Matter with Milky Way Dynamics

, 2019
There are many well-known correlations between dark matter and baryons that exist on galactic scales. These correlations can essentially be encompassed by a simple scaling relation between observed and baryonic accelerations, historically known as the ...
Lisanti, Mariangela, Moschella, Matthew, Outmezguine, Nadav Joseph, Slone, Oren   +3 more
core  

Curcumin Modulates PTPRZ1 Activity and RNA m6A Modifications in Neuroinflammation‐Associated Microglial Response

Advanced Science, EarlyView.
Wenxiang Meng and colleagues delve into the molecular mechanisms underlying curcumin's modulation of RNA post‐transcriptional N (6)‐methyladenosine (m6A) modification. It is found that curcumin interacts with the Z1‐type protein tyrosine phosphatase receptor (PTPRZ1), maintaining its enzymatic activity and thus regulating the phosphorylation of the m6A‐
Ninan Zhang, Ruifan Lin, Wenya Gao, Honglin Xu, Yuejia Li, Xiahe Huang, Yingchun Wang, Xianghong Jing, Wenxiang Meng, Qi Xie   +9 more
wiley   +1 more source

Decoding the Galactic Twirl: The Downfall of Milky Way-mass Galaxies Rotation Curves in the FIRE Simulations [PDF]

arXiv
Recent measurements of the Milky Way rotation curve found a sharp decline at around $15$-$20$ kpc from the center of the Galaxy, suggesting that the Galactic dark matter halo is much less massive than predicted by other dynamical tracers. To address this tension, we study the validity of the assumptions made in calculating the Milky Way's rotation ...
arxiv  

Roles of Kdm6a and Kdm6b in Regulation of Mammalian Neural Regeneration

Advanced Science, EarlyView.
This study reveals that Kdm6a plays key roles in repressing either peripheral nervous system (PNS) or central nervous system (CNS) axon regeneration, whereas Kdm6b is not involved in regulating CNS axon regeneration. Moreover, both demethylases are able to regulate CNS neuronal survival after injury, but with non‐overlapping mechanisms.
Shu‐Guang Yang, Chang‐Ping Li, Xue‐Wei Wang, Tao Huang, Cheng Qian, Qiao Li, Ling‐Rui Zhao, Si‐Yu Zhou, Chen‐Yun Ding, Rui Nie, Saijilafu, Yu‐Cai Hong, Chang‐Mei Liu, Feng‐Quan Zhou   +13 more
wiley   +1 more source

Revealing Gas Inflows Toward the Galactic Central Molecular Zone

The Astrophysical Journal Letters
We study the gas inflows toward the Galactic Central Molecular Zone (CMZ) based on the gas morphological and kinematic features from the Milky Way Imaging Scroll Painting in the region of l = 1.°2–19.°0 and ∣ b ∣ ≲ 3.°0.
Yang Su, Shiyu Zhang, Yan Sun, Ji Yang, Qing-Zeng Yan, Shaobo Zhang, Zhiwei Chen, Xuepeng Chen, Xin Zhou, Lixia Yuan   +9 more
doaj   +1 more source

On The Dynamics Of The Milky Way And Its Satellites In The Gaia Era

, 2017
We live in a new era in Astrophysics driven by the launch of the European satellite Gaia. Gaia is currently mapping our Galaxy by measuring distances and motions of one billion stars with exquisite accuracy and unprecedented detail. It is fair to say that the impact of this space mission on our understanding of galaxy evolution and dynamics will be ...
openaire   +2 more sources

PCSK9 Promotes the Malignancy of Triple‐negative Breast Cancer Cells by Reducing Cholesterol Levels at the Plasma Membrane to Activate EGFR and HER3

Advanced Science, EarlyView.
By decreasing cholesterol and lipid raft levels in the plasma membrane, proprotein convertase subtilisin/kexin type 9 (PCSK9) boosts human epidermal growth factor receptor 1 and 3 (EGFR and HER3) activation, driving tumor growth and metastasis in triple‐negative breast cancer (TNBC).
Tianhong Li, Renfei Wu, Kathy Qian Luo
wiley   +1 more source

GD-1 Stellar Stream and Cocoon in the DESI Early Data Release

The Astrophysical Journal
We present  ∼115 new spectroscopically identified members of the GD-1 tidal stream observed with the 5000-fiber Dark Energy Spectroscopic Instrument (DESI).
M. Valluri, P. Fagrelius, S. E. Koposov, T. S. Li, Oleg Y. Gnedin, E. F. Bell, R. G. Carlberg, A. P. Cooper, J. Aguilar, S. Ahlen, C. Allende Prieto, V. Belokurov, L. Beraldo e Silva, D. Brooks, A. Byström, T. Claybaugh, K. Dawson, A. Dey, P. Doel, J. E. Forero-Romero, E. Gaztañaga, S. Gontcho A Gontcho, J. Han, K. Honscheid, T. Kisner, A. Kremin, A. Lambert, M. Landriau, L. Le Guillou, M. E. Levi, A. de la Macorra, M. Manera, P. Martini, G. E. Medina, A. Meisner, R. Miquel, J. Moustakas, A. D. Myers, J. Najita, C. Poppett, F. Prada, M. Rezaie, G. Rossi, A. H. Riley, E. Sanchez, D. Schlegel, M. Schubnell, D. Sprayberry, G. Tarlé, G. Thomas, B. A. Weaver, R. H. Wechsler, R. Zhou, H. Zou   +53 more
doaj   +1 more source