Results 151 to 160 of about 1,984 (304)
Advanced Science, EarlyView.In PCOS patients with hyperandrogenemia, decreased ferritin heavy chain 1 (FTH1) causes Fe2⁺ overload and ferroptosis in trophoblasts. Androgens induce FTH1 protein degradation via AR‐LAMP2A‐mediated chaperone‐mediated autophagy pathway, leading to placental development disruption and early pregnancy loss. Metformin mitigates androgen‐induced placental
Hanjing Zhou +10 more
wiley +1 more source
Advanced Science, EarlyView.This study presents an engineered human interferon‐lambda (hIFN‐λ) as an intranasal prophylactic against respiratory viruses. By combining AI‐guided backbone redesign and glycoengineering, the authors developed a thermostable, protease‐resistant, and scalable variant with improved mucosal penetration.
Jeongwon Yun +12 more
wiley +1 more source
The history of dynamics and stellar feedback revealed by the H I filamentary structure in the disk of the Milky Way [PDF]
, 2020 J. D. Soler +21 more
openalex +1 more source
Advanced Science, EarlyView.The SNARE protein YKT6 is upregulated in bladder cancer (BLCA), correlating with poor prognosis. YKT6 promotes tumor proliferation and metastasis by activating Wnt/β‐catenin signaling. It recruits Ubiquitin‐Specific Peptidase 7 (USP7) to deubiquitinate and stabilize β‐catenin, enhancing its nuclear accumulation and driving oncogenic gene expression ...
Sheng Tu +16 more
wiley +1 more source
Spectral Analysis of the Orbital Dynamics of Globular Clusters in the Central Region of the Milky Way [PDF]
A. T. Bajkova +2 more
openalex +1 more source
Nearly coeval intermediate-age Milky Way star clusters at very different dynamics evolutionary stages [PDF]
, 2019 Andrés E. Piatti +2 more
openalex +1 more source
Milky Way globular cluster dynamics: are they preferentially co-rotating? [PDF]
, 2020 Saikat Das, Nirupam Roy
openalex +1 more source
Enlighten the dark in the Milky Way with dynamical models
, 2015 Since the first studies of galactic rotation curves we have seen evidence of a dark mass component in the halos of galaxies we can not observe directly. As the motion of astronomical objects are sensitive to the underlying gravitational potential, we can use dynamical models to infer the distribution of dark matter in galaxies including the Milky Way ...
openaire +2 more sources
NDST3‐Induced Epigenetic Reprogramming Reverses Neurodegeneration in Parkinson's Disease
Advanced Science, EarlyView.NDST3‐mediated epigenetic reprogramming revitalizes neuronal circuits in the substantia nigra and striatum to halt dopaminergic neuron degeneration and restore motor function in Parkinson's disease models. This strategy promotes neuronal maintenance and functional recovery, highlighting NDST3's therapeutic potential in neurodegenerative disorders ...
Yujung Chang +18 more
wiley +1 more source
Advanced Science, EarlyView.PDAC has a poor prognosis due to chemoresistance. We revealed that MCU upregulation is associated with chemoresistance and stemness in PDAC. MCU‐mediated Ca2+ influx induced ER stress, activating the PERK‐ATF4/NRF2 axis to enhance PSAT1/SLC711 expression and glutathione synthesis, reducing ROS and maintaining stemness.
Zekun Li +17 more
wiley +1 more source