Results 161 to 170 of about 43,519 (315)

Revealing Gas Inflows Toward the Galactic Central Molecular Zone

The Astrophysical Journal Letters
We study the gas inflows toward the Galactic Central Molecular Zone (CMZ) based on the gas morphological and kinematic features from the Milky Way Imaging Scroll Painting in the region of l = 1.°2–19.°0 and ∣ b ∣ ≲ 3.°0.
Yang Su, Shiyu Zhang, Yan Sun, Ji Yang, Qing-Zeng Yan, Shaobo Zhang, Zhiwei Chen, Xuepeng Chen, Xin Zhou, Lixia Yuan   +9 more
doaj   +1 more source

Topoisomerase I Inhibition in ETV4‐overexpressed Non‐Small Cell Lung Cancer Promotes Replication and Transcription Mediated R‐Loop Accumulation and DNA Damage

Advanced Science, EarlyView.
The oncogenic ETS factor ETV4 exerts a pleiotropic control over DNA replication both in a transcription‐dependent and ‐independent fashion in NSCLC cells. High‐ETV4 expression leads to R‐loop formation and DNA damage in response to TOP1 inhibition.
Jiaxi Zhang, Yan Wang, Shanhu Cao, Shelly M. Xie, Bei Liu, Yimeng Li, Yuqi Hou, Xue Meng, Mingzhu Ruan, Di Bu, Jia Kang, Ruxin Li, Lei Lou, Juan Wang, Lingxiao Xing   +14 more
wiley   +1 more source

How do the dynamics of the Milky Way–Large Magellanic Cloud system affect gamma-ray constraints on particle dark matter? [PDF]

, 2022
Christopher Eckner, Francesca Calore, Denis Erkal, Sophia Lilleengen, Michael Petersen   +4 more
openalex   +3 more sources

GD-1 Stellar Stream and Cocoon in the DESI Early Data Release

The Astrophysical Journal
We present  ∼115 new spectroscopically identified members of the GD-1 tidal stream observed with the 5000-fiber Dark Energy Spectroscopic Instrument (DESI).
M. Valluri, P. Fagrelius, S. E. Koposov, T. S. Li, Oleg Y. Gnedin, E. F. Bell, R. G. Carlberg, A. P. Cooper, J. Aguilar, S. Ahlen, C. Allende Prieto, V. Belokurov, L. Beraldo e Silva, D. Brooks, A. Byström, T. Claybaugh, K. Dawson, A. Dey, P. Doel, J. E. Forero-Romero, E. Gaztañaga, S. Gontcho A Gontcho, J. Han, K. Honscheid, T. Kisner, A. Kremin, A. Lambert, M. Landriau, L. Le Guillou, M. E. Levi, A. de la Macorra, M. Manera, P. Martini, G. E. Medina, A. Meisner, R. Miquel, J. Moustakas, A. D. Myers, J. Najita, C. Poppett, F. Prada, M. Rezaie, G. Rossi, A. H. Riley, E. Sanchez, D. Schlegel, M. Schubnell, D. Sprayberry, G. Tarlé, G. Thomas, B. A. Weaver, R. H. Wechsler, R. Zhou, H. Zou   +53 more
doaj   +1 more source

Structure and Dynamics of the Milky Way: an Astro2010 Science White Paper

, 2009
M. J. Reid, K. M. Menten, A. Brunthaler, G. Moellenbrock   +3 more
openalex   +2 more sources

LRRC8A Regulates Outer Hair Cell Volume and Electromotility and is Required for Hearing

Advanced Science, EarlyView.
This study identifies LRRC8A‐dependent volume‐regulated anion channels (VRACs) as essential for cochlear outer hair cells' electromotility and auditory signal amplification. LRRC8A deficiency disrupts cell volume control, impairs auditory sensitivity, and causes deafness, while targeted LRRC8A re‐expression restores auditory function.
Shengnan Wang, Yuehui Xi, Qiaojun Fang, Sai Shi, Fei Wang, Fuyu Xian, Zhongyang Zhang, Yuxin Yang, Xishuo Jin, Xiaomin Wang, Chen Cao, Hailin Zhang, Nikita Gamper, Zhigang Xu, Haitao Shen, Ping Lv   +15 more
wiley   +1 more source

Nearly coeval intermediate-age Milky Way star clusters at very different dynamics evolutionary stages [PDF]

, 2019
Andrés E. Piatti, M S Angelo, W. S. Dias   +2 more
openalex   +1 more source

Acod1 Promotes PAD4 Ubiquitination via UBR5 Alkylation to Modulate NETosis and Exert Protective Effects in Sepsis

Advanced Science, EarlyView.
In this study, Acod1 knockout in CLP mice significantly increases peripheral blood NET levels, exacerbating inflammation, organ damage, and reducing survival. Further research shows that UBR5 interacts with PAD4, a key NET formation protein. Acod1/itaconate (ITA) enhances the enzymatic activity of UBR5 by alkylating the Cys2768 site, promoting the K48 ...
Huifan Liu, Guoqing Jing, Shujuan Wu, Min Yuan, Yingyue Dong, Xue Chen, Huimin Zhou, Hailong Gong, Jing Zuo, Xiaojing Wu, Xuemin Song   +10 more
wiley   +1 more source

The Escape Velocity Profile of the Milky Way from Gaia DR3

The Astrophysical Journal
The escape velocity profile of the Milky Way offers a crucial and independent measurement of its underlying mass distribution and dark matter (DM) properties.
Cian Roche, Lina Necib, Tongyan Lin, Xiaowei Ou, Tri Nguyen   +4 more
doaj   +1 more source

IncRNA‐ZFAS1, an Emerging Gate‐Keeper in DNA Damage‐Dependent Transcriptional Regulation

Advanced Science, EarlyView.
LncZFAS1 plays a crucial role during DNA damage response in mammalian cells. Loss of lncZFAS1 results in deficient DNA lesion removal and reduced cell viability. Mechanistically, lncZFAS1 modulates RNAPII phosphorylation and transcription and thereby promotes both GG‐NER and TC‐NER upon UV damage.
Jiena Liu, Qing Lu, Zixuan Fan, Jiahui Lin, Nan He, Xin Zhang, Zhaoya Han, Tingting Zhu, Zhenzhen Wu, Yingying Xu, Yuming Wang   +10 more
wiley   +1 more source