Results 141 to 150 of about 155,710 (341)

The Milky Way Radial Metallicity Gradient as an Equilibrium Phenomenon: Why Old Stars Are Metal Rich

The Astrophysical Journal
Metallicities of both gas and stars decline toward large radii in spiral galaxies, a trend known as the radial metallicity gradient. We quantify the evolution of the metallicity gradient in the Milky Way as traced by APOGEE red giants with age estimates ...
James W. Johnson, David H. Weinberg, Guillermo A. Blanc, Ana Bonaca, Gwen C. Rudie, Yuxi (Lucy) Lu, Bronwyn Reichardt Chu, Emily J. Griffith, Tawny Sit, Jennifer A. Johnson, Liam O. Dubay, Miqaela K. Weller, Daniel A. Boyea, Jonathan C. Bird   +13 more
doaj   +1 more source

β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations

Advanced Biology, Volume 9, Issue 3, March 2025.
Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio, B. Spedicato, G. Corallo, A. Inguscio, M. Greco, D. Musarò, D. Vergara, A. F. Muro, G. De Sabbata, L. R. Soria, N. Brunetti Pierri, M. Maffia   +11 more
wiley   +1 more source

Targeting RAGE with Nanobodies for Molecular Imaging of Cancers and Alzheimer's Disease

Advanced Biology, EarlyView.
RAGE‐specific nanobodies were isolated via phage display and characterized by ELISA, cell ELISA, and SPR. In vivo imaging in renal carcinoma and Alzheimer's disease mouse models demonstrated that NbF8, the highest‐affinity clone, selectively targeted RAGE‐overexpressing tumors and brain tissues, highlighting its potential as a molecular imaging agent ...
Guangfeng Liang, Fujing Wang, Wei Xiong, Guangwei Shi, Junling Yuan, Yang Li, Hongyan Zhang, Yanmei Xing, Shan Jin, Kongjun Yang, Zhongliang Dai, Jichao Sun, Zhijie Li, Jianhong Wang   +13 more
wiley   +1 more source

True Pair-instability Supernova Descendant: Implications for the First Stars’ Mass Distribution

The Astrophysical Journal Letters
The initial mass function (IMF) of the first Population III (Pop III) stars remains a persistent mystery. Their predicted massive nature implies the existence of stars exploding as pair-instability supernovae (PISNe), but no observational evidence had ...
Ioanna Koutsouridou, Stefania Salvadori, Ása Skúladóttir   +2 more
doaj   +1 more source

Dynamical evolution of a bulge in an N-body model of the Milky Way

EPJ Web of Conferences, 2012
The detailed dynamical structure of the bulge in the Milky Way is currently under debate. Although kinematics of the bulge stars can be well reproduced by a boxy-bulge, the possible existence of a small embedded classical bulge can not be ruled out.
Gerhard O., Martinez-Valpuesta I., Saha K.   +2 more
doaj   +1 more source

Secular evolution of Milky Way-type galaxies

, 2017
The internal evolution of disk galaxies like the Milky Way are driven by non-axisymmetries (bars) and the implied angular momentum transfer of the matter; baryons are essentially driven inwards to build a more concentrated disk. This mass concentration may lead to the decoupling of a secondary bar, since the orbit precessing frequency is then much ...
openaire   +3 more sources

The Potential for Extracellular Vesicles in Nanomedicine: A Review of Recent Advancements and Challenges Ahead

Advanced Biology, EarlyView.
Extracellular vesicles (EVs) play a dual role in diagnostics and therapeutics, offering innovative solutions for treating cancer, cardiovascular, neurodegenerative, and orthopedic diseases. This review highlights EVs’ potential to revolutionize personalized medicine through specific applications in disease detection and treatment.
Farbod Ebrahimi, Anjali Kumari, Samaneh Ghadami, Saqer Al Abdullah, Kristen Dellinger   +4 more
wiley   +1 more source

A North–South Metallicity Asymmetry in the Outer Galactic Disk—Evidence for the Pericentric Passage of the Sagittarius Dwarf Galaxy

The Astrophysical Journal Letters
We present maps of the mean metallicity distributions on the Galactocentric R – Z plane at different azimuthal angles using red clump stars selected from the LAMOST and APOGEE surveys.
Chun Wang, Yang Huang, Timothy C. Beers, Payel Das, Haibo Yuan, Lizhi Xie, Shi Shao   +6 more
doaj   +1 more source

The ESO-Max Planck photometric and spectroscopic survey in the south: EMPhaSSiS

EPJ Web of Conferences, 2012
EMPhaSSiS is a photometric and spectroscopic survey of the disk of the Milky Way. The survey covers 33 fields in the 3rd quadrant of the Milky Way and probes every ten degrees in Galactic Longitude between l = 180∘ - 280∘ and at Galactic Latitudes of b =
Ibata R., Lane R., Lewis G., Bensby T., Noël N., Martin N., Rix H.-W., Ederoclite A., Conn B., Irwin M., Beers T., Lee Y.S.   +11 more
doaj   +1 more source

HMGB1 Derived from the Pyroptotic Microenvironment Promotes Macrophage Extracellular Traps in Hirschsprung‐Associated Enterocolitis

Advanced Biology, EarlyView.
HMGB1 derived from the pyroptotic environment in Hirschsprung‐associated enterocolitis mediates the formation of macrophage extracellular traps through TLR4 ‐p38 MAPK/p65 NF‐kB signaling pathways. Macrophage extracellular traps induce increased ROS production and pyroptosis of colonic epithelial cells.
Rui Zhang, Jing Li, Lili Song, Liya Pan, Chengchen Zhang, Zhiyan Zhan, Li Hong   +6 more
wiley   +1 more source