Results 141 to 150 of about 75,563 (322)

A Novel Brain Penetrable Nanocarrier Delivers Brain‐Derived Neurotrophic Factor to Treat Alzheimer's Disease

Advanced Healthcare Materials, EarlyView.
A novel blood‐brain barrier‐penetrating terpolymer nanoparticle to deliver brain‐derived neurotrophic factor (BDNF) for the treatment of Alzheimer's disease (AD) is designed. The BDNF‐TPN significantly enhances BDNF accumulation in the brain following intravenous injection, reduces apoptosis and neuroinflammation, thus promoting neuronal survival and ...
Lily Yi Li, Elliya Park, Chunsheng He, Azhar Z. Abbasi, Pei Zhi, Paul E. Fraser, Andrew M. Rauth, Jeffery T. Henderson, Xiao Yu Wu   +8 more
wiley   +1 more source

THE SAGITTARIUS DWARF GALAXY: A MODEL FOR EVOLUTION IN A TRIAXIAL MILKY WAY HALO [PDF]

, 2010
David R. Law, Steven R. Majewski
openalex   +1 more source

ROS‐Scavenging Multifunctional Microneedle Patch Facilitating Wound Healing

Advanced Healthcare Materials, EarlyView.
A reactive oxygen species (ROS) scavenging and immunomodulatory microneedle patch based on hyaluronic acid methacrylate (HaMA) and Flightless I (Flii)‐siRNA‐laden arginine functionalized poly (β‐amino ester)/alginate particles is developed for chronic wound healing applications.
Mahshid Kharaziha, Sahar Salehi, Mahshid Shokri, Seyed Mohsen Ahmadi Tafti, Thomas Scheibel   +4 more
wiley   +1 more source

Chemical evolution models for spiral disks: the Milky Way, M 31, and M 33 [PDF]

, 2010
M. M. Marcon-Uchida, F. Matteucci, R. D. D. Costa   +2 more
openalex   +1 more source

Silencing Myostatin Using In Vivo Self‐Assembled siRNA Protects Against Cancer‐ and Dexamethasone‐Induced Muscle Atrophy

Advanced Healthcare Materials, EarlyView.
This study reports an in vivo self‐assembled siRNA strategy that enables the liver to generate small extracellular vesicles (sEVs) tagged with a muscle‐targeting peptide (MSP) and naturally loaded with myostatin (MSTN)‐siRNA. These MSP‐tagged sEVs are systemically delivered to skeletal muscle, efficiently silence MSTN, promote muscle hypertrophy, and ...
Xin Yin, Azhar Anwar, Jiehao Chen, Qinghao Sun, Likun Zhou, Jie Tang, Jingwei Guo, Linbo Yan, Yongci Chen, Feng Yin, Chen‐Yu Zhang, Zigang Li, Jizheng Ma, Liyuan Sheng, Xi Chen   +14 more
wiley   +1 more source

Integrin β4‐Enriched Small Extracellular Vesicle as Drug Delivery Vehicle for Targeting Pulmonary Metastasis of Hepatocellular Carcinoma

Advanced Healthcare Materials, EarlyView.
The expression of integrin β4 (ITGβ4) on small extracellular vesicle (sEV) correlates with lung‐tropism. Enrichment of ITGβ4 on sEVs enhances their lung‐targeting ability. The sEVs loaded with doxorubicin exhibit superior therapeutic efficacy in a lung metastasis mouse model.
Tung Him Ng, Aijun Liang, Maximus CF Yeung, Sze Keong Tey, Kam‐Leung Siu, Sin‐Yee Fung, Dong‐Yan Jin, Judy Wai Ping Yam   +7 more
wiley   +1 more source

Efficient and Accurate Force Replay in Cosmological-baryonic Simulations

The Astrophysical Journal
We construct time-evolving gravitational potential models for a Milky Way–mass galaxy from the FIRE-2 suite of cosmological-baryonic simulations using basis function expansions.
Arpit Arora, Robyn Sanderson, Christopher Regan, Nicolás Garavito-Camargo, Emily Bregou, Nondh Panithanpaisal, Andrew Wetzel, Emily C. Cunningham, Sarah R. Loebman, Adriana Dropulic, Nora Shipp   +10 more
doaj   +1 more source

"Fermi" bubbles are bursting from our galaxy. Their origins remain a mystery. [PDF]

Proc Natl Acad Sci U S A, 2023
Mann A.
europepmc   +1 more source

THE INFLUENCE OF RADIAL STELLAR MIGRATION ON THE CHEMICAL EVOLUTION OF THE MILKY WAY [PDF]

, 2013
Yue Wang, Gang Zhao
openalex   +1 more source

Evolution of the grain size distribution in Milky Way-like galaxies in post-processed IllustrisTNG simulations [PDF]

, 2020
Yu-Hsiu Huang, Hiroyuki Hirashita, Yun-Hsin Hsu, Yen‐Ting Lin, Dylan Nelson, Andrew P. Cooper   +5 more
openalex   +1 more source