Results 121 to 130 of about 7,795,018 (296)

MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation

FEBS Open Bio, EarlyView.
MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima, Kotone Watanabe, Grigorii Sultanakhmetov, Aoi Fukuchi, Keiya Ito, Sawako Shimizu, Taro Saito, Akiko Asada, Kanae Ando   +8 more
wiley   +1 more source

The Three-Phase Evolution of the Milky Way

, 2023
We illustrate the formation and evolution of the Milky Way over cosmic time, utilizing a sample of 10 million red giant stars with full chemodynamical information, including metallicities and $\alpha$-abundances from low-resolution Gaia XP spectra.
Bonaca, Ana, Andrae, Rene, Chandra, Vedant, Semenov, Vadim A., Li, Jiadong, Hernquist, Lars, Conroy, Charlie, Rix, Hans-Walter, Naidu, Rohan P.   +8 more
core  

Type I interferons modulate autophagy to shape gemcitabine response in pancreatic cancer cells

FEBS Open Bio, EarlyView.
Type I interferons differentially modulate autophagy and the response of pancreatic cancer cells to gemcitabine. IFNα2b stimulates autophagic flux and protects cells from gemcitabine‐induced cell death, contributing to chemoresistance. In contrast, IFNβ1a inhibits autophagosome formation and enhances gemcitabine‐induced cell death, resulting in ...
Lucy E. Bonilla, Martín M. Ledesma, Santiago A. Behr, Matías A. Pibuel, María L. Palanek, Daniel H. Grasso, Maria N. Garcia, Juan Garona, Silvina L. Lompardía, Elida Álvarez, Daniela L. Papademetrio   +10 more
wiley   +1 more source

Resolved Mass Assembly and Star Formation in Milky Way Progenitors since z = 5 from JWST/CANUCS: From Clumps and Mergers to Well-ordered Disks

The Astrophysical Journal
We present a resolved study of 877 progenitors of Milky Way Analogs (MWAs) at 0.3 
Vivian Yun Yan Tan, Adam Muzzin, Ghassan T. E. Sarrouh, Jacqueline Antwi-Danso, Visal Sok, Naadiyah Jagga, Gregor Rihtaršič, Westley Brown, Roberto Abraham, Yoshihisa Asada, Guillaume Desprez, Kartheik Iyer, Nicholas S. Martis, Rosa M. Mérida, Lamiya A. Mowla, Gaël Noirot, Kiyoaki Christopher Omori, Marcin Sawicki, Roberta Tripodi, Chris J. Willott   +19 more
doaj   +1 more source

Comprehensive Characterization of 98 Chinese Cases of Genetic Creutzfeldt‐Jakob Disease With T188K Mutation

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterize the demographic, clinical, and laboratory features of the Chinese patients of genetic Creutzfeldt‐Jakob disease with T188K variant (T188K‐gCJD), the most common subtype of genetic prion diseases (gPrDs) in China. Methods In this nationwide retrospective study, data from 98 genetically confirmed T188K‐gCJD patients ...
Chun‐Jie Li, Dong‐Lin Liang, Li‐Ping Gao, Wei‐Wei Zhang, Wei Zhou, A. Ruhan, Bing Xu, Run‐Dong Cao, Kang Xiao, Cao Chen, Qi Shi, Xiao‐Ping Dong   +11 more
wiley   +1 more source

Dynamical evolution of Milky Way globular clusters on the cosmological timescale [PDF]

Context. Based on the Gaia DR3, we reconstructed the orbital evolution of the known Milky Way globular clusters and found that six objects, NGC 6681, NGC 6981, Palomar 6, NGC 6642, HP 1, and NGC 1904, very likely interact closely with the nuclear star ...
Berczik, P., Mukhagali Kalambay, Anton Gluchshenko, Oleksandr Veles, Kuvatova, D., Gluchshenko, A., Veles, O., Olexander Sobodar, Kalambay, M., Taras Panamarev, Maryna Ishchenko, Dana Kuvatova, Sobolenko, M., Ishchenko, M., Omarov, C., Margaryta Sobolenko, Panamarev, T., Sobodar, O., Chingis Omarov, Peter Berczik   +19 more
core   +1 more source

Galactic Chemical Evolution Models Favor an Extended Type Ia Supernova Delay-time Distribution

The Astrophysical Journal
Type Ia supernovae (SNe Ia) produce most of the Fe-peak elements in the Universe and therefore are a crucial ingredient in galactic chemical evolution models.
Liam O. Dubay, Jennifer A. Johnson, James W. Johnson   +2 more
doaj   +1 more source

β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations

Advanced Biology, Volume 9, Issue 3, March 2025.
Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio, B. Spedicato, G. Corallo, A. Inguscio, M. Greco, D. Musarò, D. Vergara, A. F. Muro, G. De Sabbata, L. R. Soria, N. Brunetti Pierri, M. Maffia   +11 more
wiley   +1 more source

Gradient‐Conductivity Architecture Enables Synchronous Enhancement of Sensitivity and Detection Range in Multifunctional All‐Paper Sensors

Advanced Functional Materials, EarlyView.
A gradient‐engineered all‐paper sensor is fabricated by integrating MXene and in situ grown AgNPs within hierarchical cellulose networks. The device breaks the sensitivity–detection range trade‐off through cascaded conductive pathways, enabling ultrahigh pressure sensitivity, humidity–pressure decoupled dual‐mode sensing, and outstanding EMI shielding,
Ao Li, Jun Xu, Dezhong Xu, Zhaohui Zhang, Jiyi Li, Daxian Cao, Kefu Chen, Mizi Fan   +7 more
wiley   +1 more source

Gas accretion onto the Milky Way

, 2017
The Milky Way is surrounded by large amounts of gaseous matter that are slowly being accreted over cosmic timescales to support star formation in the disk.
Richter, Philipp (Prof. Dr.)
core   +1 more source