Results 101 to 110 of about 7,795,018 (296)

Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells

FEBS Open Bio, EarlyView.
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai, Yong Xu, Jingjing Ma, Ratchanee Duangrat, Chen Yan, Jingyan Liang, Hua Wei, Bin Jiang, Tao‐Sheng Li   +8 more
wiley   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Milky Way of Words

, 2016
No Full ...
Frank, Jane
core  

Signatures of a Tidally Induced Spiral Arm at the Anticenter of the Milky Way and a Kinematically Extended Anticenter Stream Using DESI Data Release 2

The Astronomical Journal
Using the Dark Energy Spectroscopic Instrument (DESI) Milky Way Survey, we examine the six-dimensional space of the anticenter region of the Milky Way stellar disk (150° < Galactic longitude < 220°) using 61,883 main-sequence turnoff stars.
Mika Lambert, Constance M. Rockosi, Sergey E. Koposov, Ting S. Li, Monica Valluri, Leandro Beraldo e Silva, Songting Li, João A. S. Amarante, Amanda Byström, Gustavo E. Medina, Nathan R. Sandford, Joan Najita, Namitha Kizhuprakkat, Jessica N. Aguilar, Steven Ahlen, Davide Bianchi, David Brooks, Todd Claybaugh, Kyle Dawson, Axel de la Macorra, Peter Doel, Jaime E. Forero-Romero, Enrique Gaztañaga, Satya Gontcho A Gontcho, Gaston Gutierrez, Richard Joyce, Anthony Kremin, Claire Lamman, Martin Landriau, Laurent Le Guillou, Marc Manera, Aaron Meisner, Ramon Miquel, John Moustakas, Adam Myers, Seshadri Nadathur, Will Percival, Francisco Prada, Ignasi Pérez-Ràfols, Graziano Rossi, Eusebio Sanchez, David Schlegel, Michael Schubnell, Joseph H. Silber, David Sprayberry, Gregory Tarlé, Benjamin A. Weaver, Rongpu Zhou, Hu Zou   +48 more
doaj   +1 more source

The Chemical Evolution of the Milky Way Galaxy

, 2021
The elemental abundance gradients of elements up to Zn are predicted using the N body Monte Carlo technique by developing homogenous and heterogeneous Galactic Chemical Evolution (GCE) simulations. In the case of homogeneous GCE models, the galaxy is radially divided into eight annular rings of 2 kpc width each at a distance of 2-18 kpc from the center
openaire   +2 more sources

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

The evolution of dark matter substructure [PDF]

, 2001
This thesis investigates the dynamical evolution of systems orbiting within deeper potentials. Initially we use a simple satellite-halo interaction to study the dynamical processes that act on orbiting systems and we compare these results to analytical ...
Roldán, Carlos Antonio Calcáneo
core  

SF-R You Sure? The Conflicting Role of Star Formation Rates in Constraining the Evolution of Milky Way Analogs in Cosmological Simulations

The Astrophysical Journal
Milky Way analogs (MWAs) have long been studied by astronomers to place our Galaxy within an extragalactic context. With the power of cosmological simulations, we are now able to not only characterize MWAs today, but also watch as they evolve through ...
Alicia M. Savelli, Joshua S. Speagle, J. Ted Mackereth, Norman Murray, Kartheik G. Iyer   +4 more
doaj   +1 more source

Exploring the influence of lactoferrin on wound healing and related signaling pathways: a systematic review

FEBS Open Bio, EarlyView.
Lactoferrin promotes wound healing by activating MAPK, PI3K/Akt, and extracellular matrix pathways, enhancing fibroblast remodeling, proliferation, and re‐epithelialization. These mechanisms highlight its therapeutic potential in inflammation control, tissue repair, and remodeling.
Morgana Lüdtke Azevedo, Kátia Cristiane Hall, Matheus dos Santos Fernandez, Geovanna Peter Corrêa, Rafael Guerra Lund   +4 more
wiley   +1 more source

A Galactic Self-portrait: Density Structure and Integrated Properties of the Milky Way Disk

The Astrophysical Journal
The evolutionary history of the Milky Way disk is imprinted in the ages, positions, and chemical compositions of individual stars. In this study, we derive the intrinsic density distribution of different stellar populations using the final data release ...
Julie Imig, Jon A. Holtzman, Gail Zasowski, Jianhui Lian, Nicholas F. Boardman, Alexander Stone-Martinez, J. Ted Mackereth, Moire K. M. Prescott, Rachael L. Beaton, Timothy C. Beers, Dmitry Bizyaev, Michael R. Blanton, Katia Cunha, José G. Fernández-Trincado, Catherine E. Fielder, Sten Hasselquist, Christian R. Hayes, Misha Haywood, Henrik Jönsson, Richard R. Lane, Steven R. Majewski, Szabolcs Mészáros, Ivan Minchev, David L. Nidever, Christian Nitschelm, Jennifer Sobeck   +25 more
doaj   +1 more source