Results 81 to 90 of about 8,049,523 (305)

The Extremely Metal-rich Knot of Stars at the Heart of the Galaxy

The Astrophysical Journal
We show with Gaia XP spectroscopy that extremely metal-rich (EMR) stars in the Milky Way ([M/H] _XP ≳ 0.5) are largely confined to a tight “knot” at the center of the Galaxy. This EMR knot is round in projection, has a fairly abrupt edge near R _GC,proj ∼
Hans-Walter Rix, Vedant Chandra, Gail Zasowski, Annalisa Pillepich, Sergey Khoperskov, Sofia Feltzing, Rosemary F. G. Wyse, Neige Frankel, Danny Horta, Juna Kollmeier, Keivan Stassun, Melissa K. Ness, Jonathan C. Bird, David Nidever, José G. Fernández-Trincado, João A. S. Amarante, Chervin F. P. Laporte, Jianhui Lian   +17 more
doaj   +1 more source

Chemical Evolution of the Milky Way and Its Satellites [PDF]

, 2014
To appear on the Proceedings of the 37th Saas-Fee Advanced Course of the Swiss Society for Astrophysics and Astronomy, " The Origin of the Galaxy and the Local Group", eds. E. Grebel and B.
openaire   +2 more sources

Radial migration and chemical evolution in the Milky Way

, 2016
International audienceThe role of radial migration on the chemical evolution of the Milky Way is studied with semi-analytical models of disk evolution, using several new/updated ingredients and parametrized prescriptions for blurring and churning.
N. Prantzos, Prantzos, N.
core   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

The Milky Way’s Rowdy Neighbors: The Effects of the Large Magellanic Cloud and Sagittarius Dwarf on the Milky Way Disk

The Astrophysical Journal
The Milky Way (MW) is a barred spiral galaxy shaped by tidal interactions with its satellites. The Large Magellanic Cloud (LMC) and the Sagittarius dwarf galaxy (Sgr) are the dominant influences at the present day. This paper presents a suite of four 10 ^
Ioana A. Stelea, Jason A. S. Hunt, Kathryn V. Johnston   +2 more
doaj   +1 more source

4MOST Consortium Survey 3: Milky Way disc and bulge low-resolution survey (4MIDABLE-LR)

, 2019
The mechanisms of the formation and evolution of the Milky Way are encoded in the orbits, chemistry and ages of its stars. With the 4MOST MIlky way Disk And BuLgE Low-Resolution Survey (4MIDABLE-LR) we aim to study kinematic and chemical substructures in
Feltzing, S., Kovalev, M., Rix, H., Monari, G., Fouesneau, M., Ryde, N., Traven, G., Storm, J., Fusillo, N.~G., Tremblay, P., Xiang, M., Khalatyan, A., Casagrande, L., Lemasle, B., Asplund, M., Queiroz, A.~B.~D.~A., Fusillo, N., Kordopatis, G., Zucker, D., Steinmetz, M., Bensby, T., Cescutti, G., de Queiroz, A., Minchev, I., Schwope, A., Matijevic, G., Bergemann, M., McMillan, P., Anders, F., Church, R., Walton, N., Gerhard, O., Arentsen, A., Tremblay, P. -E., Chiappini, C., Grebel, E.~K., Team, 4MIDABLE-Lr, Guiglion, G., Rybizki, J., Queiroz, A., Starkenburg, E., Valentini, M., Team, 4., Rix, H. -W., Andrae, R., Grebel, E., McMillan, P.,, Church, R.,, Bensby, T.,, Lund University., Feltzing, S.,, Traven, G.,, Ryde, N.,   +52 more
core   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

What Is Missing from the Local Stellar Halo?

The Astrophysical Journal
The Milky Way’s stellar halo, which extends to >100 kpc, encodes the evolutionary history of our Galaxy. However, most studies of the halo to date have been limited to within a few kiloparsecs of the Sun.
Katherine Sharpe, Rohan P. Naidu, Charlie Conroy   +2 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Watching Our Galaxy Grow Up: The Mass and Color Evolution of the Milky Way

The Astrophysical Journal
Using our rich observations within the Milky Way to better understand galaxy evolution requires understanding what the Milky Way looks like “as a galaxy”—that is, its “true” shape and abundance profiles (unskewed by observational biases), signatures of ...
Gail Zasowski, Julie Imig, Hayley Coluccio   +2 more
doaj   +1 more source