Results 81 to 90 of about 247,055 (324)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Additional Evidence for the Existence of a Primordial Disk System

The Astrophysical Journal
The origin of very metal-poor (VMP; [Fe/H] ≤ −2.0) stars on planar orbits has been the subject of great attention since their first discovery. However, prior to the release of the Gaia BP/RP (XP) spectra and large photometric samples such as SkyMapper ...
Shuai Xu, Haibo Yuan, Bowen Huang, Timothy C. Beers, Yang Huang, Maosheng Xiang, Kai Xiao, Jihye Hong, Young Sun Lee, Wuming Yang   +9 more
doaj   +1 more source

Angular Momentum Variation of the Milky Way Thick Disk: The Dependence of Chemical Abundance and Evidence of the Inside-out Formation Scenario

The Astrophysical Journal, 2023
We investigate the angular momentum of mono-abundance populations (MAPs) of the Milky Way thick disk by using a sample of 26,076 giant stars taken from APOGEE Data Release (DR) 17 and Gaia early DR3.
Guozhen Hu, Zhengyi Shao, Lu Li
doaj   +1 more source

Evolution over time of the Milky Way's disc shape [PDF]

, 2017
Context. Galactic structure studies can be used as a path to constrain the scenario of formation and evolution of our Galaxy. The dependence with the age of stellar population parameters would be linked with the history of star formation and dynamical ...
E. Amôres, A. Robin, C. Reylé
semanticscholar   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Secular evolution of Milky Way-type galaxies

, 2017
The internal evolution of disk galaxies like the Milky Way are driven by non-axisymmetries (bars) and the implied angular momentum transfer of the matter; baryons are essentially driven inwards to build a more concentrated disk.
Combes, F.
core   +1 more source

Constraining the Milky Way Halo Accretion History with Simulated Stellar Halos: Designing the HALO7D-X Survey

The Astrophysical Journal
We present the design for HALO7D-X, a survey of the stellar halo to investigate the accretion history of the Milky Way. The survey will use a combination of Hubble Space Telescope (HST) and Gaia data for sky position and proper motions of faint stars (18 
Miranda Apfel, Kevin McKinnon, Constance M. Rockosi, Puragra Guhathakurta, Kathryn V. Johnston   +4 more
doaj   +1 more source

On the origin of fluorine in the Milky Way

, 2004
The main astrophysical factories of fluorine (19F) are thought to be Type II supernovae, Wolf-Rayet stars, and the asymptotic giant branch (AGB) of intermediate mass stars.
Agostino Renda, Alessandro Chieffi, Alibés, Allende Prieto, Amanda I. Karakas, Bekki, Bertelli, Brad K. Gibson, Cappellaro, Cunha, Dray, Fenner, Forestini, Frost, Frost, Gibson, Holweger, Iglesias, Iwamoto, John C. Lattanzio, Jorissen, Karakas, Karakas, Katia Cunha, Kroupa, Limongi, Lugaro, Meynet, Mowlavi, Myra, Rana, Renzini, Russell, Schaller, Simon Campbell, Smith, Timmes, Vassiliadis, Verne V. Smith, Woosley, Woosley, Woosley, Woosley, Yeshe Fenner   +43 more
core   +2 more sources

Black Hole Starvation and Bulge Evolution in a Milky Way-like Galaxy [PDF]

, 2015
We present a new zoom-in hydrodynamical simulation, "Erisbh", which follows the cosmological evolution and feedback effects of a supermassive black hole at the center of a Milky Way-type galaxy.
Bellovary, Jillian, Bonoli, Silvia, Governato, Fabio, Kazantzidis, Stelios, Madau, Piero, Mayer, Lucio   +5 more
core   +2 more sources

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source