Results 81 to 90 of about 7,795,018 (296)

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

A 3D Chemodynamical Census of Inner-Galaxy Metal-poor Giants to [Fe/H] ∼ −3.5

The Astrophysical Journal Letters
The earliest assembly of the Milky Way remains poorly understood, yet the spatial, chemical, and kinematic properties of its most metal-poor stars provide a unique fossil record of its proto-Galaxy phase.
Shenglan Sun, Yang Huang, Fangzhou Jiang, Huawei Zhang, Xiang-Xiang Xue, Timothy C. Beers, Chengye Cao, Qikang Feng, Ruizhi Zhang, Haiyang Xing, João A. S. Amarante   +10 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

The Extremely Metal-rich Knot of Stars at the Heart of the Galaxy

The Astrophysical Journal
We show with Gaia XP spectroscopy that extremely metal-rich (EMR) stars in the Milky Way ([M/H] _XP ≳ 0.5) are largely confined to a tight “knot” at the center of the Galaxy. This EMR knot is round in projection, has a fairly abrupt edge near R _GC,proj ∼
Hans-Walter Rix, Vedant Chandra, Gail Zasowski, Annalisa Pillepich, Sergey Khoperskov, Sofia Feltzing, Rosemary F. G. Wyse, Neige Frankel, Danny Horta, Juna Kollmeier, Keivan Stassun, Melissa K. Ness, Jonathan C. Bird, David Nidever, José G. Fernández-Trincado, João A. S. Amarante, Chervin F. P. Laporte, Jianhui Lian   +17 more
doaj   +1 more source

Detection of a Supervirial Hot Component in the Milky Way Circumgalactic Medium Along Multiple Sight Lines by Using the Stacking Technique

The Astrophysical Journal, 2023
The study of the elusive hot component ( T ≳ 10 ^7 K) of the Milky Way circumgalactic medium (CGM) is a novel topic for understanding Galactic formation and evolution.
Armando Lara-DI, Smita Mathur, Yair Krongold, Sanskriti Das, Anjali Gupta   +4 more
doaj   +1 more source

Evolution of lithium in the Milky Way halo, discs, and bulge [PDF]

Monthly Notices of the Royal Astronomical Society, 2019
Abstract In this work, we study the Galactic evolution of lithium by means of chemical evolution models in the light of the most recent spectroscopic data from Galactic stellar surveys. We consider detailed chemical evolution models for the Milky Way halo, discs, and bulge, and we compare our model predictions with the most recent ...
Grisoni, V., Matteucci, F., Romano, D., Fu, X.   +3 more
openaire   +5 more sources

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

The Milky Way’s Rowdy Neighbors: The Effects of the Large Magellanic Cloud and Sagittarius Dwarf on the Milky Way Disk

The Astrophysical Journal
The Milky Way (MW) is a barred spiral galaxy shaped by tidal interactions with its satellites. The Large Magellanic Cloud (LMC) and the Sagittarius dwarf galaxy (Sgr) are the dominant influences at the present day. This paper presents a suite of four 10 ^
Ioana A. Stelea, Jason A. S. Hunt, Kathryn V. Johnston   +2 more
doaj   +1 more source

Chemical Evolution of the Milky Way and Its Satellites [PDF]

, 2014
To appear on the Proceedings of the 37th Saas-Fee Advanced Course of the Swiss Society for Astrophysics and Astronomy, " The Origin of the Galaxy and the Local Group", eds. E. Grebel and B.
openaire   +2 more sources

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source