Results 61 to 70 of about 7,457 (263)
Watching Our Galaxy Grow Up: The Mass and Color Evolution of the Milky Way
The Astrophysical JournalUsing our rich observations within the Milky Way to better understand galaxy evolution requires understanding what the Milky Way looks like “as a galaxy”—that is, its “true” shape and abundance profiles (unskewed by observational biases), signatures of ...
Gail Zasowski +2 more
doaj +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
The Astrophysical JournalThe Milky Way (MW) is a barred spiral galaxy shaped by tidal interactions with its satellites. The Large Magellanic Cloud (LMC) and the Sagittarius dwarf galaxy (Sgr) are the dominant influences at the present day. This paper presents a suite of four 10 ^
Ioana A. Stelea +2 more
doaj +1 more source
The evolution of dark matter substructure [PDF]
, 2001 This thesis investigates the dynamical evolution of systems orbiting within deeper potentials. Initially we use a simple satellite-halo interaction to study the dynamical processes that act on orbiting systems and we compare these results to analytical ...
Roldán, Carlos Antonio Calcáneo
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Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
The Stellar Disk Structure Revealed by the Mono-age Populations of the LAMOST Red Clump Star Sample
The Astronomical JournalUnderstanding the structure of the Galactic disk is crucial for understanding the formation and evolutionary history of the Milky Way. This study examines the structure of the Galactic disk by analyzing a sample of 138,667 primary red clump (RC) stars ...
Zheng Yu +4 more
doaj +1 more source
A Chemodynamical Simulation of Halo Stars in the Milky Way
, 2007 In this contribution, we present a new chemodynamical model for the early evolution history of the Milky Way with an improved chemical evolution description. Our new approach is based on the chemical evolution model by Tsujimoto et al. (1999).
N. Nakasato
core +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
Mapping the Chemodynamics of the Galactic Disk Using the LAMOST and APOGEE Red Clump Stars
The Astrophysical Journal Supplement SeriesA detailed measurement is made of the metallicity distributions, kinematics, and dynamics of the thin and thick disks across a large disk volume (5.0 ≤ R ≤ 15.0 kpc and ∣ Z ∣ ≤ 3.0 kpc) by using the LAMOST–APOGEE red clump stars.
Weixiang Sun +3 more
doaj +1 more source
Chemodynamical evolution of the Milky Way
, 2003 We simulate the chemodynamical evolution of the Milky Way using our GRAPE-SPH code, and reproduce the age-metallicity relation, the [O/Fe]-[Fe/H] relation, and the metallicity ...
Nomoto, K., Nakasato, N., Kobayashi, C.
core