Results 71 to 80 of about 7,457 (263)

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Strong Chemical Tagging in the Milky Way

, 2020
Comprehending the evolutionary history of the Milky Way can offer great insight into how both our home Galaxy and others form and grow. However, studying the Milky Way from our position embedded within it is difficult, and this challenge is exacerbated ...
Price-Jones, Natalie Ruth
core  

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

Signatures of a Tidally Induced Spiral Arm at the Anticenter of the Milky Way and a Kinematically Extended Anticenter Stream Using DESI Data Release 2

The Astronomical Journal
Using the Dark Energy Spectroscopic Instrument (DESI) Milky Way Survey, we examine the six-dimensional space of the anticenter region of the Milky Way stellar disk (150° < Galactic longitude < 220°) using 61,883 main-sequence turnoff stars.
Mika Lambert, Constance M. Rockosi, Sergey E. Koposov, Ting S. Li, Monica Valluri, Leandro Beraldo e Silva, Songting Li, João A. S. Amarante, Amanda Byström, Gustavo E. Medina, Nathan R. Sandford, Joan Najita, Namitha Kizhuprakkat, Jessica N. Aguilar, Steven Ahlen, Davide Bianchi, David Brooks, Todd Claybaugh, Kyle Dawson, Axel de la Macorra, Peter Doel, Jaime E. Forero-Romero, Enrique Gaztañaga, Satya Gontcho A Gontcho, Gaston Gutierrez, Richard Joyce, Anthony Kremin, Claire Lamman, Martin Landriau, Laurent Le Guillou, Marc Manera, Aaron Meisner, Ramon Miquel, John Moustakas, Adam Myers, Seshadri Nadathur, Will Percival, Francisco Prada, Ignasi Pérez-Ràfols, Graziano Rossi, Eusebio Sanchez, David Schlegel, Michael Schubnell, Joseph H. Silber, David Sprayberry, Gregory Tarlé, Benjamin A. Weaver, Rongpu Zhou, Hu Zou   +48 more
doaj   +1 more source

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source

SF-R You Sure? The Conflicting Role of Star Formation Rates in Constraining the Evolution of Milky Way Analogs in Cosmological Simulations

The Astrophysical Journal
Milky Way analogs (MWAs) have long been studied by astronomers to place our Galaxy within an extragalactic context. With the power of cosmological simulations, we are now able to not only characterize MWAs today, but also watch as they evolve through ...
Alicia M. Savelli, Joshua S. Speagle, J. Ted Mackereth, Norman Murray, Kartheik G. Iyer   +4 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

A Galactic Self-portrait: Density Structure and Integrated Properties of the Milky Way Disk

The Astrophysical Journal
The evolutionary history of the Milky Way disk is imprinted in the ages, positions, and chemical compositions of individual stars. In this study, we derive the intrinsic density distribution of different stellar populations using the final data release ...
Julie Imig, Jon A. Holtzman, Gail Zasowski, Jianhui Lian, Nicholas F. Boardman, Alexander Stone-Martinez, J. Ted Mackereth, Moire K. M. Prescott, Rachael L. Beaton, Timothy C. Beers, Dmitry Bizyaev, Michael R. Blanton, Katia Cunha, José G. Fernández-Trincado, Catherine E. Fielder, Sten Hasselquist, Christian R. Hayes, Misha Haywood, Henrik Jönsson, Richard R. Lane, Steven R. Majewski, Szabolcs Mészáros, Ivan Minchev, David L. Nidever, Christian Nitschelm, Jennifer Sobeck   +25 more
doaj   +1 more source

Chemical evolution of the Milky Way: the origin of phosphorus

, 2012
Context. Recently, the abundance of P was measured for the first time in disk stars. This provides the opportunity of comparing the observed abundances with predictions from theoretical models.
P. François, E. Caffau, CESCUTTI, GABRIELE, François, P., G. Cescutti, F. Matteucci, Cescutti, G., Caffau, E., MATTEUCCI, MARIA FRANCESCA, Matteucci, F.   +9 more
core   +1 more source

Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells

FEBS Open Bio, EarlyView.
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai, Yong Xu, Jingjing Ma, Ratchanee Duangrat, Chen Yan, Jingyan Liang, Hua Wei, Bin Jiang, Tao‐Sheng Li   +8 more
wiley   +1 more source