Results 51 to 60 of about 8,049,523 (305)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Constraining the Milky Way Halo Accretion History with Simulated Stellar Halos: Designing the HALO7D-X Survey

open access: yesThe Astrophysical Journal
We present the design for HALO7D-X, a survey of the stellar halo to investigate the accretion history of the Milky Way. The survey will use a combination of Hubble Space Telescope (HST) and Gaia data for sky position and proper motions of faint stars (18 
Miranda Apfel   +4 more
doaj   +1 more source

Disentangling Stellar Age Estimates from Galactic Chemodynamical Evolution

open access: yesThe Astrophysical Journal, 2023
Stellar ages are key for determining the formation history of the Milky Way, but are difficult to measure precisely. Furthermore, methods that use chemical abundances to infer ages may entangle the intrinsic evolution of stars with the chemodynamical ...
Jeff Shen   +4 more
doaj   +1 more source

7Li evolution in the thin and thick discs of the Milky Way [PDF]

open access: yesMonthly Notices of the Royal Astronomical Society, 2018
13 pages, 7 figures, accepted for publication in ...
Cescutti G   +3 more
openaire   +3 more sources

Structure and evolution of metallicity and age radial profiles in Milky-Way-like galaxies

open access: yes, 2018
International audienceAbstract I will give here a very short summary of some of the work I have been doing lately on the chemical evolution in Milky-Way-like spiral ...
Athanassoula, E.
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

open access: yesMolecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu   +13 more
wiley   +1 more source

Mapping the Milky Way at 21 cm Wave Length with SALSA Radio Telescope

open access: yes, 2018
<p>Milky-Way-Mapping</p> <p>Mapping of the Milky Way is a galactic mapping at 21 cm Hydrogen spectrum to determine the Spiral Structure of Milky Way Galaxy in different Galactic planes from Galactic Longitude 6-225 Degree and Latitude ...
Mir Sakhawat Hossain
core   +2 more sources

The Milky Way’s Circular Velocity Curve Measured Using Element Abundance Gradients

open access: yesThe Astrophysical Journal
Spectroscopic surveys now supply precise stellar label measurements such as element abundances for large samples of stars throughout the Milky Way. These element abundances are known to correlate with orbital actions or other dynamical invariants.
Danny Horta   +6 more
doaj   +1 more source

Contrasting copper evolution in ω Centauri and the Milky Way [PDF]

open access: yesMonthly Notices of the Royal Astronomical Society: Letters, 2007
Abstract Despite the many studies on stellar nucleosynthesis published so far, the scenario for the production of copper in stars remains elusive. In particular, it is still debated whether copper originates mostly in massive stars or in Type Ia supernovae.
Romano, Donatella, Matteucci, Francesca
openaire   +2 more sources

Stellar abundances in clusters: High-resolution, multi-object spectroscopy of globular & open clusters in the Milky Way [PDF]

open access: yes, 2015
Talk on high-resolution, multi-object spectroscopy of globular & open clusters in the Milky ...
BRAGAGLIA, Angela
core  

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