Results 31 to 40 of about 8,049,523 (305)
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
The Milky Way - Our Home in the Universe
, 2018 Aakasha Ganga, Via Lactea or the Milky Way is our home in the Universe. The discovery of the telescope by Galileo Galilei had facilitated the sky watchers to notice a variety of geometrical forms in the sky.
Divakara Mayya
core +1 more source
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
Andromeda and the Milky Way: Twin sisters, distant relations, or strangers in the night?
, 2012 I summarize some recent key results from the Pan-Andromeda Archaeological Survey (PAndAS), in particular showing how recent discoveries in and around M31 compare to the known structure of the Milky Way and its satellite ...
Richardson J. +11 more
core +1 more source
A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
FEBS Letters, EarlyView.Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source
Secular Evolution in the Milky Way [PDF]
Proceedings of the International Astronomical Union, 2012 AbstractI will review the secular evolution of the Milky Way disk and bulge with particular attention to the bulge and disk. Evidence for the importance of stellar migration in the Solar neighbourhood will be presented. The upcoming Gaia satellite will lead to a wealth of new data with which to explore these effects.
openaire +1 more source
Milky Way versus Andromeda: a tale of two disks
, 2009 Aims. We study the chemical evolution of the disks of the Milky Way (MW) and of Andromeda (M31), to identify the common properties and differences between the two major galaxies of the Local ...
J. L. Hou +13 more
core +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Observational Constraints of Radial Migration in the Galactic Disk Driven by the Slowing Bar
The Astrophysical Journal LettersRadial migration is an important dynamical effect that has reshaped the Galactic disk, but its origin has yet to be elucidated. In this work, we present evidence that resonant dragging by the corotation of a decelerating bar could be the main driver of ...
HanYuan Zhang +9 more
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source