Results 41 to 50 of about 8,242 (260)
Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source
High-resolution Chemical Abundances of the Nyx Stream
The Astrophysical Journal, 2023 Nyx is a nearby, prograde, and high-eccentricity stellar stream physically contained in the thick disk, but its origin is unknown. Nyx could be the remnant of a disrupted dwarf galaxy, in which case the associated dark matter substructure could affect ...
Shuyu Wang +7 more
doaj +1 more source
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Mapping the Chemodynamics of the Galactic Disk Using the LAMOST and APOGEE Red Clump Stars
The Astrophysical Journal Supplement SeriesA detailed measurement is made of the metallicity distributions, kinematics, and dynamics of the thin and thick disks across a large disk volume (5.0 ≤ R ≤ 15.0 kpc and ∣ Z ∣ ≤ 3.0 kpc) by using the LAMOST–APOGEE red clump stars.
Weixiang Sun +3 more
doaj +1 more source
Star Formation in the Central Molecular Zone of the Milky Way [PDF]
, 2022 Jonathan D. Henshaw +5 more
openalex +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
The Star Formation History of the Milky Way’s Nuclear Star Cluster
The Astrophysical Journal, 2023 We report the first star formation history study of the Milky Ways nuclear star cluster (NSC), which includes observational constraints from a large sample of stellar metallicity measurements.
Zhuo Chen +8 more
doaj +1 more source
FEBS Open Bio, EarlyView.Representation of the suggested mode of action of lactoferrin (Lf) in nonsmall cell lung cancer (NSCLC) A549 cells. Lf induces activation of caspase‐3 by activating p53 and AChE leading to decreased ACh concentrations. In turn, ACh signaling leads to activation of VEGF and AKT and blocking of caspase‐3.
Stuti Goel +9 more
wiley +1 more source
Constraining the formation of the Milky Way: Ages
EPJ Web of Conferences, 2013 We present a new approach for studying the chemodynamical evolution of the Milky Way, which combines a thin disk chemical evolution model with the dynamics from N-body simulation of a galaxy with properties similar to those of our Galaxy.
Martig M., Minchev I., Chiappini C.
doaj +1 more source
The Parallax and 3D Kinematics of Water Masers in the Massive Star-forming Region G034.43+0.24
The Astrophysical Journal, 2023 We report a measurement of the trigonometric parallax of 22 GHz water masers in the massive star-forming region G034.43+0.24 as part of the Bar and Spiral Structure Legacy Survey using the Very Long Baseline Array.
Xiaofeng Mai +14 more
doaj +1 more source