Results 201 to 210 of about 29,619 (304)

POLE Deficiency Exacerbates Diesel Engine Exhaust‐Induced Genomic Instability and Malignant Transformation of Bronchial Epithelial Cells

Advanced Science, EarlyView.
This study establishes a diesel engine exhaust (DEE)‐induced malignant transformation model in bronchial epithelial cells. Whole genome sequencing（WGS） and RNA‐seq reveal DEE‐induced mutational signatures and gene expression profiles. Mechanistically, DEEaffect polymerase epsilon (POLE) and mismatch repair, driving genomic instability and promoting ...
Pimei Zhang, Zhaoxu Wu, Qiang Ju, Nuo Xu, Xian Chen, Hongguang Chen, Shuaishuai Yang, Jing Ji, Yanjie Zhao   +8 more
wiley   +1 more source

The photometry and kinematics studies of NGC 2509 derived from Gaia DR3. [PDF]

Sci Rep
Ahmed NM, Tadross AL.
europepmc   +1 more source

Entropy of the Universe and Hierarchical Dark Matter. [PDF]

Entropy (Basel), 2022
Frampton PH.
europepmc   +1 more source

THE IMPACT OF STELLAR FEEDBACK ON THE STRUCTURE, SIZE, AND MORPHOLOGY OF GALAXIES IN MILKY-WAY-SIZED DARK MATTER HALOS [PDF]

, 2016
Oscar Agertz, Andrey V. Kravtsov
openalex   +1 more source

LEDGF Binds H3R17me2a Promoting De Novo Nucleotide Biosynthesis in SETD2 Mutant Clear Cell Renal Cell Carcinoma

Advanced Science, EarlyView.
In SETD2‐mutant ccRCC, the original LEDGF recognition of the H3K36me3 regulatory axis no longer exists. LEDGF interacts with CARM1‐dependent H3R17me2a regulating the transcription of key enzymes in the de novo synthesis pathway. The abnormally elevated LEDGF leads to the accumulation of purine nucleotides in SETD2‐mutant ccRCC, thereby satisfying the ...
Yuwei Zhang, Yuhua Zhou, Yuezhou Zhang, Jing Lv, Yang Shen, Dong Zhang, Bo Liu, Wei Zhao, Junyi Ju, Qingyi Zhu, Ke Wang, Ninghan Feng   +11 more
wiley   +1 more source

Evidence of star cluster migration and merger in dwarf galaxies. [PDF]

Nature
Poulain M, Smith R, Duc PA, Marleau FR, Habas R, Durrell PR, Fensch J, Lim S, Müller O, Paudel S, Sánchez-Janssen R.   +10 more
europepmc   +1 more source

The environments of the radio galaxy population in simba. [PDF]

Mon Not R Astron Soc, 2022
Thomas N, Davé R.
europepmc   +1 more source

On the stellar halo metallicity profile of Milky Way-like galaxies in the Auriga simulations [PDF]

, 2016
Antonela Monachesi, Facundo A. Gómez, Robert J. J. Grand, Guinevere Kauffmann, Federico Marinacci, Rüdiger Pakmor, Volker Springel, Carlos S. Frenk   +7 more
openalex   +1 more source

Nucleotides as an Anti‐Aging Supplementation in Older Adults: A Randomized Controlled Trial (TALENTs study)

Advanced Science, EarlyView.
The TALENTs randomized controlled trial evaluates the potential of nucleotides supplementation as an anti‐aging intervention in older adults. After 19 weeks, nucleotides supplementation significantly reduces DNA methylation age, suggesting a delay in epigenetic aging, and improves insulin sensitivity without severe adverse events.
Shuyue Wang, Lixia Song, Rui Fan, Qianqian Chen, Ruisheng Fu, Mei You, Yuxiao Wu, Meng Cai, Yong Li, Meihong Xu   +9 more
wiley   +1 more source

Tidal tail identification and detailed analysis of the open star cluster King 13 using Gaia DR3 and 2MASS. [PDF]

Sci Rep
Ahmed NM, Darwish MS.
europepmc   +1 more source