Results 221 to 230 of about 30,715 (290)

Atacama Large Aperture Submillimeter Telescope (AtLAST) science: The hidden circumgalactic medium. [PDF]

Open Res Eur
Lee M, Schimek A, Cicone C, Andreani P, Popping G, Sommovigo L, Appleton PN, Bischetti M, Cantalupo S, Chen CC, Dannerbauer H, De Breuck C, Di Mascolo L, Emonts BHC, Hatziminaoglou E, Pensabene A, Rizzo F, Rybak M, Shen S, Lundgren A, Booth M, Klaassen P, Mroczkowski T, Cordiner MA, Johnstone D, van Kampen E, Liu D, Maccarone T, Saintonge A, Smith M, Thelen AE, Wedemeyer S.   +31 more
europepmc   +1 more source

Discovery of SKP2‐Recruiting PROTACs for Target Protein Degradation

Advanced Science, EarlyView.
Based on the SKP2‐targeting ligand SL1, we designed non‐covalent PROTACs by linking it with the BRD4 inhibitor JQ1 and the AR antagonist AL through a linker. These PROTACs successfully induced the ubiquitination of BRD4 and AR, followed by proteasome‐mediated degradation.
Guanjun Dong, Aima Huang, Ziqing Zhao, Bikai Lai, Xin Pan, Huiyu Yang, Xiaohan Xu, Tianwei Wang, Fangchen Zhao, Zhimin Zhang, Yongbo Xue, Guanjun Deng, Wenbin Deng, Jianwei Chen   +13 more
wiley   +1 more source

Strong Lensing by Galaxies. [PDF]

Space Sci Rev
Shajib AJ, Vernardos G, Collett TE, Motta V, Sluse D, Williams LLR, Saha P, Birrer S, Spiniello C, Treu T.   +9 more
europepmc   +1 more source

Strong perturbation of a super-virial Magellanic circum-galactic medium

, 2023
Locatelli N, Ponti G, Merloni A, Zheng X, Dennerl K, Haberl F, Maitra C, Sanders J, Sasaki M, Vazza F.   +9 more
europepmc   +1 more source

NuSAP Safeguards Centriole Integrity to Mediate CEP57‐CEP152 Torus Recruitment for Proper Engagement

Advanced Science, EarlyView.
This study reveals a novel role for the microtubule stabilizer NuSAP at centrioles. NuSAP depletion destabilizes the centriole's tubulin structure, causing premature disengagement, PCM defects, and mis‐localization of the CEP57‐CEP63‐CEP152 complex. By reinforcing centriole architecture, NuSAP enables early CEP57 loading and initiates a newly proposed ...
Shiyu Zhang, Zemin Jiang, Qiaoyun Yang, Hong Zheng, Minghao Wang, Chennianci Zhu, Lih‐Wen Deng, Karen Carmelina Crasta, Yih‐Cherng Liou   +8 more
wiley   +1 more source

A cosmic-ray loaded nascent outflow driven by a massive star cluster. [PDF]

Nat Commun
Lemoine-Goumard M, Härer L, Mohrmann L, Bernet R, Hinton J, Peron G, Reville B, Tibaldo L, Vieu T.   +8 more
europepmc   +1 more source

Osmotic Tension Asymmetry Drives Electrotactic Migration via PDLIM7‐Polarized Microfilament Coordination in Breast Cancer Cells

Advanced Science, EarlyView.
This study establishes an electric field‐induced directional migration model using fluorescence tension probes to visualize microfilament forces and intracellular osmotic pressure dynamics in the electrotactic migration of breast cancer cells. This model delineates how electromechanical interactions among membrane potential, ion channels, OP, traction ...
Ling Zhu, Zihui Zheng, Wang Li, Chenyi Shou, Ying Zhao, Lijun Zhang, Xiaoli Shi, Yunfeng Hu, Huanhuan Zhao, Huiwen Wu, Jun Guo   +10 more
wiley   +1 more source

DNA Nanoflower LYTACs Enable Efficient VEGF Degradation and Verteporfin Loading for Combined Therapy of Wet Age‐Related Macular Degeneration

Advanced Science, EarlyView.
An integrated approach that combines a DNA nanoflower VEGF degrader with photodynamic therapy is developed for the treatment of wet age‐related macular degeneration, which reduces the risk of VEGF reactivation‐induced CNV recurrence and minimizes the systemic side effects associated with photodynamic therapy.
Mengxuan Li, Yan Yue, Sijin Wu, Xinyu He, Jiayi Song, Shuwen Ma, Haokun Zhang, Chenyu Xu, Song Chen, Yanming Huang, Songbo Xie, Hua Yan   +11 more
wiley   +1 more source

Abundant water from primordial supernovae at cosmic dawn. [PDF]

Nat Astron
Whalen DJ, Latif MA, Jessop C.
europepmc   +1 more source

Distribution and kinematics of ²⁶Al in the Galactic disc. [PDF]

Mon Not R Astron Soc, 2020
Fujimoto Y, Krumholz MR, Inutsuka SI.
europepmc   +1 more source