Results 71 to 80 of about 29,619 (304)

Targeting carbonic anhydrase IX/XII prevents the anti‐ferroptotic effect of stromal lactic acid in prostate carcinoma

open access: yesMolecular Oncology, EarlyView.
In prostate carcinoma, lactic acid, secreted by highly glycolytic cancer‐associated fibroblasts, is imported into tumor cells through the MCT1 transporter and prevents RSL3 and erastin‐induced ferroptosis (A). Targeting of carbonic anhydrase IX/XII, the main extracellular pH regulators, in tumor and stromal cells reduces microenvironmental acidosis and
Elisa Pardella   +18 more
wiley   +1 more source

Deciphering the Kinematic Substructure of Local Dark Matter with LAMOST K Giants

open access: yesThe Astrophysical Journal
Numerical simulations indicate that correlations exist between the velocity distributions of stars and dark matter (DM). We study the local DM velocity distribution based on these correlations.
Hai Zhu   +7 more
doaj   +1 more source

Alpha Element Populations Among Local Halo Stars

open access: yesThe Astronomical Journal, 2023
Previous studies have shown that the halo of the Milky Way galaxy is made up of two distinct stellar populations, one from dissipative collapse and the other accreted.
Michael V. Reinhard, John B. Laird
doaj   +1 more source

The Dual Origin of Stellar Halos II: Chemical Abundances as Tracers of Formation History [PDF]

open access: yes, 2010
Fully cosmological, high resolution N-Body + SPH simulations are used to investigate the chemical abundance trends of stars in simulated stellar halos as a function of their origin.
Adi Zolotov   +27 more
core   +3 more sources

CNS Mitochondria‐Derived Vesicle in Blood: Potential Biomarkers for Brain Mitochondria Dysfunction

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial dysfunction is a hallmark of neurodegenerative diseases like Alzheimer's (AD) and Parkinson's (PD). Our goal was to develop practical, noninvasive methods to assess mitochondrial status through the detection of mitochondria‐derived vesicles (MDVs).
Qi Liu   +12 more
wiley   +1 more source

Chemical Abundances of the Outer Halo Stars in the Milky Way

open access: yes, 2009
We present chemical abundances of 57 metal-poor stars that are likely constituents of the outer stellar halo in the Milky Way. Almost all of the sample stars have an orbit reaching a maximum vertical distance (Z_max) of >5 kpc above and below the ...
Aoki, W., Chiba, M., Ishigaki, M.
core   +1 more source

β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations

open access: yesAdvanced Biology, Volume 9, Issue 3, March 2025.
Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio   +11 more
wiley   +1 more source

A Catalog of Distance Determinations for 5 Million Stars in LAMOST DR10

open access: yesThe Astronomical Journal
Using the distance estimation method outlined in J. L. Carlin et al., a Bayesian approach specifically tailored for LAMOST data, we estimated distances for 7,450,303 spectra from 5,394,174 unique stars in the LAMOST DR10 low-resolution data set.
Chengqun Yang   +5 more
doaj   +1 more source

The puzzling assembly of the Milky Way halo – contributions from dwarf Spheroidals and globular clusters

open access: yesEPJ Web of Conferences, 2012
While recent sky surveys have uncovered large numbers of ever fainter Milky Way satellites, their classification as star clusters, low-luminosity galaxies, or tidal overdensities remains often unclear. Likewise, their contributions to the build-up of the
Lépine S., Koch A., Çalışkan Ş.
doaj   +1 more source

Stream Fanning and Bifurcations: Observable Signatures of Resonances in Stellar Stream Morphology

open access: yesThe Astrophysical Journal, 2023
Recent observations have revealed a trove of unexpected morphological features in many of the Milky Way’s stellar streams. Explanations for such features include time-dependent deformations of the Galactic gravitational potential, local disruptions ...
Tomer D. Yavetz   +4 more
doaj   +1 more source

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