Results 51 to 60 of about 589 (260)

Discovery of a New Stellar Subpopulation Residing in the (Inner) Stellar Halo of the Milky Way [PDF]

The Astrophysical Journal Letters, 2019
Abstract We report the discovery of a unique collection of metal-poor giant stars that exhibit anomalously high levels of 28Si, clearly above typical Galactic levels. Our sample spans a narrow range of metallicities, peaking at −1.07 ± 0.06, and exhibits abundance ratios of [Si, Al/Fe] that are as extreme as those observed in Galactic ...
Fernández-Trincado, José, Beers, Timothy, Placco, Vinicius, Moreno, Edmundo, Alves-Brito, Alan, Minniti, Dante, Tang, Baitian, Pérez-Villegas, Angeles, Reylé, Céline, Robin, Annie, Villanova, Sandro   +10 more
openaire   +4 more sources

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

The stability of stellar discs in Milky Way-sized dark matter haloes [PDF]

Monthly Notices of the Royal Astronomical Society, 2015
22 pages, 23 figures, 1 tables. Accepted for publication in MNRAS.
Denis Yurin, Volker Springel
openaire   +2 more sources

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Stellar halos in Illustris: probing the histories of Milky Way-mass galaxies [PDF]

Monthly Notices of the Royal Astronomical Society, 2018
13 pages, 12 ...
Lydia M Elias, Laura V Sales, Peter Creasey, Michael C Cooper, James S Bullock, R Michael Rich, Lars Hernquist   +6 more
openaire   +2 more sources

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Galactic-Seismology Substructures and Streams Hunter with LAMOST and Gaia. I. Methodology and Local Halo Results

The Astrophysical Journal
We present a novel, deep-learning-based method—dubbed Galactic-Seismology Substructures and Streams Hunter, or GS ^3 Hunter for short—to search for substructures and streams in stellar kinematics data.
Guan-Yu Wang, Hai-Feng Wang, Yang-Ping Luo, Yuan-Sen Ting, Thor Tepper-García, Joss Bland-Hawthorn, Jeffrey Carlin   +6 more
doaj   +1 more source

Diverse stellar haloes in nearby Milky Way mass disc galaxies [PDF]

Monthly Notices of the Royal Astronomical Society, 2016
26 pages, 17 figures.
Harmsen, B., Monachesi, A., Bell, E.F., Jong, R.S. de, Bailin, J., Radburn-Smith, D.J., Holwerda, B.W.   +6 more
openaire   +4 more sources

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Precise Asteroseismic Ages for the Helmi Streams

The Astrophysical Journal
The Helmi streams are remnants of a dwarf galaxy that was accreted by the Milky Way and whose stars now form a distinct kinematic and chemical substructure in the Galactic halo. Precisely age-dating these typically faint stars of extragalactic origin has
Christopher J. Lindsay, Marc Hon, J. M. Joel Ong, Rafael A. García, Dinil B. Palakkatharappil, Jie Yu, Tanda Li, Tomás Ruiz-Lara, Amina Helmi   +8 more
doaj   +1 more source