Results 41 to 50 of about 5,772,490 (206)

Stellar halos of Milky Way-type galaxies in Eagle high resolution simulations [PDF]

, 2019
We study the stellar halos of Milky Way-type galaxies in the Eagle simulations and in a new set of zoomed Milky Way-mass galaxies resimulated at higher resolution. We analyse the surface brightness, metallicity, colour and age profiles of simulated halos
McCarthy, Ian G., McCarthy, Ian G. (7257581), Font, Andreea S., Font, Andreea S. (7257578)   +3 more
core   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Dynamics All the Way Down: The Satellites, Streams, and Stellar Halo of the Milky Way in the Gaia Era [PDF]

, 2023
The release of high-precision astrometric data from the Gaia space mission has revolutionized studies of the Milky Way s halo substructures over the past few years.
Riley, Alexander H
core  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Galactic-Seismology Substructures and Streams Hunter with LAMOST and Gaia. I. Methodology and Local Halo Results

The Astrophysical Journal
We present a novel, deep-learning-based method—dubbed Galactic-Seismology Substructures and Streams Hunter, or GS ^3 Hunter for short—to search for substructures and streams in stellar kinematics data.
Guan-Yu Wang, Hai-Feng Wang, Yang-Ping Luo, Yuan-Sen Ting, Thor Tepper-García, Joss Bland-Hawthorn, Jeffrey Carlin   +6 more
doaj   +1 more source

The building blocks of the Milky Way halo using APOGEE and Gaia -- or -- Is the Galaxy a typical galaxy? [PDF]

We summarise recent results from analysis of APOGEE/Gaia data for stellar populations in the Galactic halo, disk, and bulge, leading to constraints on the contribution of dwarf galaxies and globular clusters to the stellar content of the Milky Way halo ...
Pfeffer, JL, Crain, RA, Schiavon, RP, Mackereth, JT, Bovy, J   +4 more
core   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Precise Asteroseismic Ages for the Helmi Streams

The Astrophysical Journal
The Helmi streams are remnants of a dwarf galaxy that was accreted by the Milky Way and whose stars now form a distinct kinematic and chemical substructure in the Galactic halo. Precisely age-dating these typically faint stars of extragalactic origin has
Christopher J. Lindsay, Marc Hon, J. M. Joel Ong, Rafael A. García, Dinil B. Palakkatharappil, Jie Yu, Tanda Li, Tomás Ruiz-Lara, Amina Helmi   +8 more
doaj   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Building blocks of the Milky Way's stellar halo

, 2015
We study the assembly history of the stellar halo of Milky Way-like galaxies using the six high-resolution Aquarius dark matter simulations combined with the Munich-Groningen semi-analytic galaxy formation model.
Starkenburg, Else, Nelemans, Gijs, van Oirschot, Pim, Helmi, Amina   +3 more
core   +1 more source