Results 31 to 40 of about 5,772,490 (206)

ELVES IV: The Satellite Stellar-to-Halo Mass Relation Beyond the Milky-Way [PDF]

, 2023
Quantifying the connection between galaxies and their host dark matter halos has been key for testing cosmological models on various scales. Below $M_\star \sim 10^9\,M_\odot$, such studies have primarily relied on the satellite galaxy population ...
Carlsten, Scott, Beaton, Rachael, Goulding, Andy D., Danieli, Shany, Greene, Jenny E., Jiang, Fangzhou   +5 more
core  

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

STELLAR POPULATION VARIATIONS IN THE MILKY WAY's STELLAR HALO [PDF]

, 2010
If the stellar halos of disk galaxies are built up from the disruption of dwarf galaxies, models predict highly structured variations in the stellar populations within these halos.
Christine Ruhland, Bell, Eric F., Xiang Xiang Xue, Ruhland, Christine, Hogg, David W., Eric F. Bell, Rix, Hans-Walter, Xue, Xiang Xiang, Hans-Walter Rix, David W. Hogg   +9 more
core   +1 more source

Discovery and Modeling of Milky Way Stellar Streams [PDF]

, 2021
Stellar streams, the tidal remnants of accreted globular clusters and dwarf galaxies, are uniquely powerful tools for studying the Milky Way. In particular, they allow for strong constraints on the local distribution of dark matter, and they provide ...
Shipp, Nora
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Insight Into The Formation Of The Milky Way Through Cold Halo Substructure. I. The Echos Of Milky Way Formation [PDF]

, 2009
We identify 10-seven for the first time-elements of cold halo substructure (ECHOS) in the volume within 17.5 kpc of the Sun in the inner halo of the Milky Way.
Rockosi, Constance M., Malanushenko, Viktor, Pan, Kaike, Simmons, Audrey, Bizyaev, Dmitry, Yanny, Brian, Lee, Young Sun, Oravetz, Dan, Schlaufman, Kevin C., Malanushenko, Elena, Snedden, Stephanie, Prieto, Carlos Allende, Beers, Timothy C., Brewington, Howard   +13 more
core   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

A Catalog of Distance Determinations for 5 Million Stars in LAMOST DR10

The Astronomical Journal
Using the distance estimation method outlined in J. L. Carlin et al., a Bayesian approach specifically tailored for LAMOST data, we estimated distances for 7,450,303 spectra from 5,394,174 unique stars in the LAMOST DR10 low-resolution data set.
Chengqun Yang, Xiang-Xiang Xue, Chao Liu, Hao Tian, Ling Zhu, Lan Zhang   +5 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

AuriDESI: mock catalogues for the DESI Milky Way Survey [PDF]

The Dark Energy Spectroscopic Instrument Milky Way Survey (DESI MWS) will explore the assembly history of the Milky Way by characterizing remnants of ancient dwarf galaxy accretion events and improving constraints on the distribution of dark matter in ...
de la Macorra, Axel, Ahlen, Steven, Claybaugh, Todd, Meisner, Aaron, Koposov, Sergey E, Rezaie, Mehdi, Zhou, Zhimin, Manera, Marc, Grand, Robert J J, Kizhuprakkat, Namitha, Honscheid, Klaus, Cooper, Andrew P, Dawson, Kyle, Schubnell, Michael, Tarlé, Gregory, Brooks, David, Landriau, Martin, Allende Prieto, Carlos, Seo, Hee-Jong, Nie, Jundan, Rossi, Graziano, Valluri, Monica, Miquel, Ramon, Gaztañaga, Enrique, Gontcho A Gontcho, Satya, Frenk, Carlos, Prada, Francisco, Sanchez, Eusebio, Kehoe, Robert, Aguilar, Jessica Nicole, Gnedin, Oleg Y, Riley, Alexander H, Doel, Peter, Forero-Romero, Jaime E, de la Macorra, A, Riley, Alexander H., Grand, Robert J. J., Grand, RJJ, Gaztañaga, E, Cooper, AP, Zhou, Z, Forero-Romero, JE, Prada, F, Miquel, R, Claybaugh, T, Schubnell, M, Seo, HJ, Manera, M, Forero-Romero, Jaime E., Koposov, SE, Frenk, C, Gnedin, Oleg Y., Honscheid, K, Sanchez, E, Gnedin, OY, Landriau, M, Rezaie, M, Nie, J, Prieto, Carlos Allende, Kehoe, R, Prieto, CA, Cooper, Andrew P., Tarlé, G, Brooks, D, Doel, P, Gontcho, SGA, Kizhuprakkat, N, Meisner, A, Koposov, Sergey E., Dawson, K, Valluri, M, Ahlen, S, Gontcho, Satya Gontcho A, Rossi, G, Aguilar, JN, Riley, AH   +75 more
core   +1 more source