Results 71 to 80 of about 13,860 (288)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Deciphering the Kinematic Substructure of Local Dark Matter with LAMOST K Giants
The Astrophysical JournalNumerical simulations indicate that correlations exist between the velocity distributions of stars and dark matter (DM). We study the local DM velocity distribution based on these correlations.
Hai Zhu +7 more
doaj +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
A-type stars in the Canada–France Imaging Survey I. The stellar halo of the Milky Way traced to large radius by blue horizontal branch stars [PDF]
Monthly notices of the Royal Astronomical Society, 2018 We present the stellar density profile of the outer halo of the Galaxy traced over a range of Galactocentric radii from $15< R_{GC} < 220$ kpc by blue horizontal branch (BHB) stars.
G. Thomas +16 more
semanticscholar +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Around the Way: Testing ΛCDM with Milky Way Stellar Stream Constraints [PDF]
, 2018 Recent analyses of the Pal 5 and GD-1 tidal streams suggest that the inner dark matter halo of the Milky Way is close to spherical, in tension with predictions from collisionless N-body simulations of cosmological structure formation.
B. Dai, B. Robertson, P. Madau
semanticscholar +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
A Catalog of Distance Determinations for 5 Million Stars in LAMOST DR10
The Astronomical JournalUsing the distance estimation method outlined in J. L. Carlin et al., a Bayesian approach specifically tailored for LAMOST data, we estimated distances for 7,450,303 spectra from 5,394,174 unique stars in the LAMOST DR10 low-resolution data set.
Chengqun Yang +5 more
doaj +1 more source
The stability of stellar discs in Milky Way-sized dark matter haloes [PDF]
Monthly Notices of the Royal Astronomical Society, 2015 22 pages, 23 figures, 1 tables. Accepted for publication in MNRAS.
Denis Yurin, Volker Springel
openaire +2 more sources
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source