Results 31 to 40 of about 6,401,648 (288)

mimic-2-preprocessed

, 2023
Preprocessed version of the MIMIC-II dataset.
Lukas Heumos (11460931)
core   +1 more source

Development of a machine learning-based prediction model for hypothyroidism-associated delirium in elderly hypothyroid patients in the intensive care unit

BMC Geriatrics
Background Patients with hypothyroidism admitted to the intensive care unit (ICU) frequently develop hypothyroidism-associated delirium (HAD), a condition strongly linked to adverse prognostic outcomes.
Binbin Guan, Lijing Lin, Zhou Chen, Li Ma, Libin Liu   +4 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Comparative analysis of dexmedetomidine, midazolam, and propofol impact on epilepsy-related mortality in the ICU: insights from the MIMIC-IV database

BMC Neurology
Background Dexmedetomidine (Dex), midazolam, and propofol are three distinct sedatives characterized by varying pharmacological properties. Previous literature has indicated the positive impact of each of these sedatives on ICU patients.
Xun Li, Wei Yue
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

A positive correlation between serum lactate dehydrogenase level and in-hospital mortality in ICU sepsis patients: evidence from two large databases

European Journal of Medical Research
Background Sepsis presents a significant healthcare challenge, characterized by high morbidity and mortality rates. There is a scarcity of relevant studies investigating the association between serum lactate dehydrogenase level and the prognosis of ...
Huijie Yu, Qilin Yang, Yuanwei Qian, Siyan Luo, Tianyu Kong, Guangqian Yang, Weiyan Chen, Fuhua Xie, Jieru Chen, Xuming Xiong, Deliang Wen, Zhenhui Zhang   +11 more
doaj   +1 more source

Prediction of Postoperative Stroke in Elderly Surgical ICU Patients Using Random Forest Model: Development on MIMIC-IV with Cross-Institutional and Temporal External Validation

BioMedInformatics
Postoperative stroke is a serious and fatal condition that often affects elderly surgical patients. This rare but severe complication arises from complex interactions between comorbidities, physiologic instability and demographic disturbances that ...
Houji Jin, Mohammadsaeed Haghi, Nausin Kudrot, Kamiar Alaei, Maryam Pishgar   +4 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Association between stress hyperglycemia ratio and all-cause mortality in patients with chronic obstructive pulmonary disease

Scientific Reports
The Stress Hyperglycemia Ratio (SHR) has emerged as a prognostic indicator associated with adverse outcomes in a variety of diseases. Nevertheless, the relationship between SHR and the prognosis of individuals with chronic obstructive pulmonary disease ...
Yunxiang Chen, Anbang Liu, Liping Zhang, Xinlong Wan, Jing Jiao, Zhigang Sun   +5 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source