Results 51 to 60 of about 6,401,648 (288)

L-shaped association of body mass index with prognosis in individuals with sepsis: a multicenter cohort study

Diabetology & Metabolic Syndrome
Objective The relationship between body mass index (BMI) and sepsis prognosis remains highly controversial and uncertain. This study investigated the association between BMI and prognosis in patients with sepsis.
Kunping Cui, Xiangnan Teng, Wei liu, Xiaoxiao Zhao, Shanling Xu, Lang Bai   +5 more
doaj   +1 more source

Association between short-term systemic use of glucocorticoids and prognosis of cardiogenic shock: a retrospective analysis

BMC Anesthesiology, 2023
Objective To investigate the prescription rate of short-term systemic use of glucocorticoids during hospitalization in patients with cardiogenic shock (CS), and outcomes related with glucocorticoid use. Methods We extracted patients' information from the
Hua-Ping Fan, Yan Zhou, Yu Zhou, Jun Jin, Tian-Yang Hu   +4 more
doaj   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

The PaO2/FiO2 is independently associated with 28-day mortality in patients with sepsis: a retrospective analysis from MIMIC-IV database

BMC Pulmonary Medicine, 2023
Background To clarify the relationship between the PaO2/FiO2 and 28-day mortality in patients with sepsis. Methods This was a retrospective cohort study regarding MIMIC-IV database.
Hongying Bi, Xu Liu, Chi Chen, Lu Chen, Xian Liu, Jianmin Zhong, Yan Tang   +6 more
doaj   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Unveiling the prognostic power of FIB-4 index: a new frontier in heart failure mortality

European Journal of Medical Research
Background The fibrosis-4 (FIB-4) index is valuable in predicting cardiovascular events in individuals with type 2 diabetes. This paper was to ascertain the predictive power of FIB-4 for mortality in patients with heart failure (HF). Methods Patient data
Wen Lu, Changxi Wang, Hansong Zhu, Xi Zheng, Ji Fang, Min Lin, Yan Zheng, Kaiyang Lin, Yansong Guo   +8 more
doaj   +1 more source

Association of platelet-to-lymphocyte ratio with sepsis based on MIMIC-IV database

Vojnosanitetski pregled
Background/Aim. Sepsis is a potentially lethal condition that ranks among the most severe medical disorders globally and results in elevated mortality rates. The aim of this study was to examine the correlation between sepsis outcomes in patients and the platelet-to-lymphocyte ratio (PLR), including mortality and duration of intensive care unit (ICU ...
Hui Zhao, Kai Wang, Zhiheng Li, Lili Mao, Jinli Miao, Yan Sun   +5 more
openaire   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Factors influencing sepsis associated thrombocytopenia (SAT): A multicenter retrospective cohort study.

PLoS ONE
IntroductionSepsis associated thrombocytopenia (SAT) is a common complication of sepsis. We designed this study to investigate factors influencing SAT.MethodsPatients with sepsis (2984 in Peking union medical college hospital [PUMCH] database, 13165 in ...
Lu Wang, Jieqing Chen, Xiang Zhou, China National Critical Care Quality Control Centre Group (China-NCCQC)   +3 more
doaj   +1 more source