Results 61 to 70 of about 6,401,648 (288)

Salzburg Intensive Care database (SICdb): a detailed exploration and comparative analysis with MIMIC-IV

Scientific Reports
AbstractThe utilization of artificial intelligence (AI) in healthcare is on the rise, demanding increased accessibility to (public) medical data for benchmarking. The digitization of healthcare in recent years has facilitated medical data scientists’ access to extensive hospital data, fostering AI-based research. A notable addition to this trend is the
Sina Sadeghi, Lars Hempel, Niklas Rodemund, Toralf Kirsten   +3 more
openaire   +3 more sources

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Exploring the potential effects of acute respiratory failure on patients with early-stage bronchopulmonary cancer

Scientific Reports
Acute respiratory failure is a common disease, impacting various cancer survivors and reflecting post-surgery complications. However, little evidence based on respiratory failure has been developed for prognostic assessment and prediction in patients ...
Ziwen Lv, Qi Feng, Junhui Gu, Zhuo Gao, Dong Liu   +4 more
doaj   +1 more source

Alveolar–arterial oxygen gradient nonlinearly impacts the 28‐day mortality of patients with sepsis: Secondary data mining based on the MIMIC‐IV database

The Clinical Respiratory Journal, 2023
Objective Lung is often implicated in sepsis, resulting in acute respiratory distress syndrome (ARDS). The alveolar–arterial oxygen gradient [D(A‐a)O2] reflects lung diffusing capacity, which is usually compromised in ARDS.
Ying Wang, Yan He, Lu Chen, Ying Liu, Jia Yuan, Hongying Bi, Qimin Chen, Xianjun Chen, Feng Shen   +8 more
doaj   +1 more source

Exploring the influence of lactoferrin on wound healing and related signaling pathways: a systematic review

FEBS Open Bio, EarlyView.
Lactoferrin promotes wound healing by activating MAPK, PI3K/Akt, and extracellular matrix pathways, enhancing fibroblast remodeling, proliferation, and re‐epithelialization. These mechanisms highlight its therapeutic potential in inflammation control, tissue repair, and remodeling.
Morgana Lüdtke Azevedo, Kátia Cristiane Hall, Matheus dos Santos Fernandez, Geovanna Peter Corrêa, Rafael Guerra Lund   +4 more
wiley   +1 more source

Nighttime intensive care unit admission increased 30-day mortality in sepsis patients: a retrospective propensity-score matched analysis based on MIMIC-IV database

Scientific Reports
Although there has been extensive research on the mortality and prognosis of sepsis, none of them has been focused on the association between mortality and timing of admission to intensive care unit (ICU) in sepsis patients. This study used MIMIC-IV data
Cheng Peng, Tianqi Shen, Jie Peng, Xueming Wu, Jie Yan, Yongjun Zheng, Haimiao Wu, Fan Gao   +7 more
doaj   +1 more source

Evaluation of Argatroban in Sepsis-Induced Coagulopathy: A Retrospective Study Based on MIMIC-IV Database

Clinical and Applied Thrombosis/Hemostasis
Background Sepsis-Induced Coagulopathy (SIC) is common complications of sepsis in intensive care unit (ICU) patients. It has a significant impact on the prognosis of patients with sepsis and is an important cause of death. However, there is no evidence for the use of Argatroban in SIC anticoagulant therapy.
Jiaqi Tang, Hongguang Ding, Zhiwei Su, Hongke Zeng   +3 more
openaire   +2 more sources

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Dual native G‐quadruplex folding is associated with chromatin looping at the MYC locus

FEBS Open Bio, EarlyView.
BG4‐detectable G‐quadruplex (G4) in HaCaT and NHEK keratinocytes identified folded and unfolded G4s enriched at promoters/TSSs and active enhancers, whereas unfolded G4s also overlapped weak/poised enhancers. At MYC–PVT1, 3C‐qPCR detected enhancer–promoter looping only when G4s were simultaneously folded at both regulatory elements under native ...
Dieila Giomo de Lima, Gustavo Narvaes Guimarães, Emilyane de Oliveira Santana Amaral, Bianca Caroline Figueiredo Bianco, Manuel Jara‐Espejo, Sérgio Roberto Peres Line, Ana Paula de Souza, Aline Cristiane Planello   +7 more
wiley   +1 more source

Diabetes–TyG interaction and mortality in critical cerebrovascular disease: a retrospective cohort study

Scientific Reports
Critically ill cerebrovascular disease (CVD) patients face high mortality, yet modifiable prognostic factors remain underexplored. The triglyceride-glucose (TyG) index has emerged as a surrogate marker of insulin resistance, but its association with ...
Hui Wang, Xiaojun Ding, Xuelei Cao, Jinglei Lv   +3 more
doaj   +1 more source