Results 131 to 140 of about 179,288 (364)

Hypoxia promotes vasculogenic mimicry formation by vascular endothelial growth factor A mediating epithelial‐mesenchymal transition in salivary adenoid cystic carcinoma

Cell Proliferation, 2019
To investigate the role of hypoxia in vasculogenic mimicry (VM) of salivary adenoid cystic carcinoma (SACC) and the underlying mechanism involved.
Hao-Fan Wang, Sha-Sha Wang, Min Zheng, Lu-ling Dai, Ke Wang, Xiao-lei Gao, Ming-xin Cao, Xiang-hua Yu, Xin Pang, Mei Zhang, Jing-biao Wu, Jia-shun Wu, Xiao Yang, Ya-Jie Tang, Yu Chen, Ya-Ling Tang, Xin-hua Liang   +16 more
semanticscholar   +1 more source

Machine Learning‐Enabled Polymer Discovery for Enhanced Pulmonary siRNA Delivery

Advanced Functional Materials, EarlyView.
This study provides an efficient approach to train a machine learning model by merging heterogeneous literature data to predict suitable polymers for siRNA delivery. Without the need for extensive laboratory synthesis, the machine learning enabled a virtual screening and successfully predicted a polymer that is validated for effective gene silencing in
Felix Sieber‐Schäfer, Min Jiang, Adrian Kromer, Anny Nguyen, Müge Molbay, Simone Pinto Carneiro, David Jürgens, Gerald Burgstaller, Bastian Popper, Benjamin Winkeljann, Olivia Monika Merkel   +10 more
wiley   +1 more source

Improving the Breadth of the Host’s Immune Response to Lassa Virus

Pathogens, 2018
In 2017, the global Coalition for Epidemic Preparedness (CEPI) declared Lassa virus disease to be one of the world’s foremost biothreats. In January 2018, World Health Organization experts met to address the Lassa biothreat.
Juan Carlos Zapata, Sandra Medina-Moreno, Camila Guzmán-Cardozo, Maria S. Salvato   +3 more
doaj   +1 more source

Targeting the pregnane X receptor using microbial metabolite mimicry

bioRxiv, 2019
The human pregnane X receptor (PXR), a master regulator of drug metabolism, has important roles in intestinal homeostasis and abrogating inflammation. Existing PXR ligands have substantial off-target toxicity.
Z. Dvořák, F. Kopp, Cait M. Costello, Jazmin S. Kemp, Hao Li, Aneta Vrzalová, M. Štěpánková, Iveta Bartoňková, Eva Jiskrová, Karolína Poulíková, Barbora Vyhlídalová, L. Nordstroem, Chamini V. Karunaratne, H. S. Ranhotra, K. Mun, A. Naren, I. Murray, G. Perdew, J. Brtko, L. Toporova, A. Schön, W. Wallace, W. Walton, M. Redinbo, Katherine Y. Sun, A. Beck, S. Kortagere, Michelle C. Neary, A. Chandran, S. Vishveshwara, M. M. Cavalluzzi, G. Lentini, J. Cui, Haiwei Gu, J. March, S. Chatterjee, A. Matson, D. Wright, K. Flannigan, S. Hirota, R. Sartor, S. Mani   +41 more
semanticscholar   +1 more source

Printed Integrated Logic Circuits Based on Chitosan‐Gated Organic Transistors for Future Edible Systems

Advanced Functional Materials, EarlyView.
Edible electronics needs integrated logic circuits for computation and control. This work presents a potentially edible printed chitosan‐gated transistor with a design optimized for integration in circuits. Its implementation in integrated logic gates and circuits operating at low voltage (0.7 V) is demonstrated, as well as the compatibility with an ...
Giulia Coco, Valerio Francesco Annese, Valerio Galli, Ilaria Penna, Debora Russo, Marina Veronesi, Rita Scarpelli, Stefania Sabella, Mario Caironi   +8 more
wiley   +1 more source

Molecular mimicry, genetic homology, and gene sharing proteomic “molecular fingerprints” using an EBV (Epstein-Barr virus)-derived microarray as a potential diagnostic method in autoimmune disease [PDF]

, 2018
EBV (Epstein-Barr Virus) and other human DNA viruses are associated with autoimmune syndromes in epidemiologic studies. In this work, immunoglobulin G response to EBV-encoded proteins which share regions with human immune response proteins from the human
Alessandra Farina, Giuseppina, Dreyfus, David H., FARINA, Antonella   +2 more
core   +1 more source

Mechanisms of Vasculogenic Mimicry in Ovarian Cancer

Frontiers in Oncology, 2019
Solid tumors carry out the formation of new vessels providing blood supply for growth, tumor maintenance, and metastasis. Several processes take place during tumor vascularization.
L. Ayala-Domínguez, Leslie Olmedo-Nieva, J. O. Muñoz-Bello, A. Contreras-Paredes, J. Manzo-Merino, Imelda Martínez-Ramírez, M. Lizano   +6 more
semanticscholar   +1 more source

Engineering Topographical Cues to Enhance Neural Regeneration in Spinal Cord Injury: Overcoming Challenges and Advancing Therapies

Advanced Functional Materials, EarlyView.
Spinal cord injury (SCI) poses significant challenges for regeneration due to a series of secondary injury mechanisms. How to use biomaterial approach to target the failed regeneration after SCI remains a critical challenge. This review systematically evaluates current strategies to optimize biomaterial topographies for neurite outgrowth, axonal ...
Wei Xu, Fenghui Wang, Joshua Stein, Siqiao Wang, Pengfei Jiang, Letao Yang, Liming Cheng, Ki‐Bum Lee   +7 more
wiley   +1 more source

Vers une alternative au paradigme de la rationalité ? Victoires et déboires du programme spinoziste en économie.

Œconomia, 2014
Recently, Frederic Lordon has been devising an ambitious research programme aimed at superseding the rationality paradigm that draws on the work of Spinoza.
Michaël Lainé
doaj   +1 more source

Social top-down response modulation (STORM): a model of the control of mimicry in social interaction [PDF]

, 2012
Human social interaction is complex and dynamic(Hari and Kujala,2009).Individuals communicate with each other by means of multiple verbal and nonverbal behaviors,which rapidly change from moment to moment.Unraveling mechanisms underlying the subtlety of ...
Hamilton, AFDC, Wang, Y
core