Results 41 to 50 of about 169 (131)

Nuclear Import Defects Drive Cell Cycle Dysregulation in Neurodegeneration

Aging Cell, Volume 24, Issue 8, August 2025.
Overview of Dysregulated Cell Cycle Mechanisms in Neuronal Cells. A nuclear import block drives cell cycle re‐entry from G0, culminating in cell cycle arrest at G1/S. This cell cycle arrest is associated with activation of CKIs from the INK locus (p15, p16, p18, p19) and Cip/Kip (p21, p27) which act on specific CDK/Cyclin complexes.
Jonathan Plessis‐Belair, Taylor Russo, Markus Riessland, Roger B. Sher   +3 more
wiley   +1 more source

Comprehensive Network pharmacology and in vitro investigation of L-mimosine: unveiling multi-targeted therapeutic potential against breast cancer

BMC Complementary Medicine and Therapies
Breast cancer remains the leading cause of mortality among women globally, primarily due to its heterogeneity and complex pathophysiology. Conventional treatments such as surgery, radiation therapy, and chemotherapy often face limitations, including ...
Jyoti Kumari Yadav, Krupa Shah, Mohammadfesal Ghanchi, Gaurang sindhav, Saumya Patel, Rakesh Rawal   +5 more
doaj   +1 more source

An update on leucaena toxicity: Is inoculation with Synergistes jonesii necessary?

Tropical Grasslands-Forrajes Tropicales, 2019
Keynote paper presented at the International Leucaena Conference, 1‒3 November 2018, Brisbane, Queensland, Australia. Concern about mimosine toxicity and its management has contributed to the restricted adoption of leucaena as a forage for ruminants ...
H. Max Shelton, Graham Kerven, Scott A. Dalzell   +2 more
doaj   +1 more source

A new spin on chemotaxonomy: Using non‐proteogenic amino acids as a test case

Applications in Plant Sciences, Volume 13, Issue 4, July-August 2025.
Abstract Premise Specialized metabolites serve various roles for plants and humans. Unlike core metabolites, specialized metabolites are restricted to certain plant lineages; thus, in addition to their ecological functions, specialized metabolites can serve as diagnostic markers of plant lineages.
Makenzie Gibson, William Thives Santos, Alan R. Oyler, Lucas Busta, Craig A. Schenck   +4 more
wiley   +1 more source

Fishing for protective compounds

eLife, 2020
A new zebrafish study identifies compounds that shield ears and kidneys against an anticancer drug.
Giuliano Ciarimboli
doaj   +1 more source

Effect on Arabica Coffee Flavor Quality of Enhanced Fermentation With Pichia membranifaciens Through Change Microbial Communities and Chemical Compounds

Food Science &Nutrition, Volume 13, Issue 7, July 2025.
Weissella, Lactococcus, Trichococcus, Leuconostoc, and Massila at the bacterial general level and Pichia, Hanseniaspora, Lachancea, Candida, and Cystofilobasidium at the fungi general level were the predominant microorganisms during the enhanced fermentation of Arabica coffee.
Xiaojing Shen, Qi Wang, Jia Zheng, Xingyu Li, Song Li, Yanhua Yin, Mengli Shang, Kunyi Liu, Wenjuan Yuan, Jilai Zhang   +9 more
wiley   +1 more source

Dynamic Changes of Microbial Communities and Chemical Compounds During the Dry Processing of Coffea arabica

Food Science &Nutrition, Volume 13, Issue 4, April 2025.
Tatumella, Klebsiella, Gluconobacter, Brevundimonas, and Staphylococcus at the bacterial general level and Candida, Lachancea, Aschersonia, Cercospora, and Pichia at the fungi general level were the predominant microorganisms during the dry processing of Coffea arabica.
Xiaojing Shen, Qi Wang, Biao Yuan, Zhiheng Yin, Muzi Li, Runxin Shi, Kunyi Liu, Wenjuan Yuan   +7 more
wiley   +1 more source

Study on the causal relationship and optimise the extraction procedure of herbal preparation from Herba Mimosae pudicae, Folium Erythrinae variegatae, Cortex Cinnamomi iners and Herba et radix Scopariae

Vietnam Journal of Science, Technology and Engineering
Herbal preparations from four herbs - Mimosa pudica, Erythrina variegata, Scoparia dulcis, and Cinnamomum iners - exhibit sedative effects, treat insomnia, and effectively reduce anxiety and depression. The chemical components present in these medicinal
Oanh - Hoang Hua, Van- Thi- Thanh Nguyen, Nam- Van- Ho Phan, Kiet- Khang Chung, Quyen- Hong- To Duong   +4 more
doaj   +3 more sources

Hypoxic Responses in Periodontal Tissues: Influence of Smoking and Periodontitis

Journal of Clinical Periodontology, Volume 52, Issue 2, Page 249-257, February 2025.
ABSTRACT Aim This study aimed to investigate the hypoxic changes in periodontal tissues resulting from smoking and periodontitis by assessing levels of hypoxia‐inducible factors (HIF‐1α, HIF‐2α, HIF‐3α) and vascular endothelial growth factor (VEGF) in gingival crevicular fluid (GCF).
Bejna Bozyel, Özlem Doğan, Serenay Elgün, Burcu Özdemir   +3 more
wiley   +1 more source

Mimosine Is a Cell-specific Antagonist of Folate Metabolism [PDF]

Journal of Biological Chemistry, 2000
Iron deficiency and iron chelators are known to alter folate metabolism in mammals, but the underlying biochemical mechanisms have not been established. Although many studies have demonstrated that the iron chelators mimosine and deferoxamine inhibit DNA replication in mammalian cells, their mechanism of action remains controversial.
E W, Oppenheim, I M, Nasrallah, M G, Mastri, P J, Stover   +3 more
openaire   +2 more sources