Results 31 to 40 of about 3,183 (234)

Mimosine Targets Serine Hydroxymethyltransferase [PDF]

Journal of Biological Chemistry, 1996
The plant amino acid, mimosine, is an extremely effective inhibitor of DNA replication in mammalian cells (Mosca, P. J., Dijkwel, P. A., and Hamlin, J. L. (1992) Mol. Cell. Biol. 12, 4375-4383). Mimosine appears to prevent the formation of replication forks at early-firing origins when delivered to mammalian cells approaching the G1/S boundary, and ...
H B, Lin, R, Falchetto, P J, Mosca, J, Shabanowitz, D F, Hunt, J L, Hamlin   +5 more
openaire   +2 more sources

Low mimosine content and nutrient-rich foliage of two Leucaena leucocephala varieties: a potential fodder resource in Mediterranean agroforestry systems

Plant Biosystems, 2022
Leucaena leucocephala is worldwide used for wood production, reforestation and for feeding livestock. To assess the potential use of leucaena for animal nutrition, we analysed the composition of methanolic extracts of leaf samples of two varieties ...
E. Badalamenti, A. Maggio, A. Dardi, Antonio Palumbo Piccionello, T. La Mantia   +4 more
semanticscholar   +1 more source

Generation of reactive oxygen species by hydroxypyridone compound/iron complexes

Redox Report, 2020
Objectives: Prooxidant properties of iron-binding hydroxypyridone compounds including deferiprone and mimosine were analyzed. Methods: Hydroxypyridone/iron-dependent production of reactive oxygen species was evidenced by the inactivation of aconitase ...
Keiko Murakami, Masataka Yoshino
doaj   +1 more source

Mimosine

, 2023
Mimosine parameters for Amber ff99sb and 03 force fields in Gromacs ...
David De Sancho
core   +1 more source

Potency Of Andrographolide, L-Mimosine And Asiaticoside Compound As Antiviral For Covid-19 Based On In Silico Method

Proceedings University of Muhammadiyah Yogyakarta Undergraduate Conference, 2022
Introduction - COVID-19 is an infectious disease that is a global challenge, making it necessary for innovation and the development of antiviral agents in prevention and treatment efforts.
D. Ningrum, D. Aini, Melisa Juniananda, Rifki Febriansah   +3 more
semanticscholar   +1 more source

The identification of dual protective agents against cisplatin-induced oto- and nephrotoxicity using the zebrafish model

eLife, 2020
Dose-limiting toxicities for cisplatin administration, including ototoxicity and nephrotoxicity, impact the clinical utility of this effective chemotherapy agent and lead to lifelong complications, particularly in pediatric cancer survivors.
Jaime N Wertman, Nicole Melong, Matthew R Stoyek, Olivia Piccolo, Stewart Langley, Benno Orr, Shelby L Steele, Babak Razaghi, Jason N Berman   +8 more
doaj   +1 more source

A novel methylated analogue of L-Mimosine exerts its therapeutic potency through ROS production and ceramide-induced apoptosis in malignant melanoma

Investigational new drugs, 2021
Melanoma is an aggressive and highly metastatic type of skin cancer where the design of new therapies is of utmost importance for the clinical management of the disease.
S. Kyriakou, William K. C. Cheung, T. Mantso, M. Mitsiogianni, I. Anestopoulos, S. Veuger, D. Trafalis, R. Franco, Aglaia Pappa, D. Tétard, M. Panayiotidis   +10 more
semanticscholar   +1 more source

DNA Breaks Induction by Mimosine

Zeitschrift für Naturforschung C, 2003
Abstract Mouse erythroleukemic F4 N cells were treated with mimosine, etoposide, Fe(II)-EDTA, and Cu(II) in the presence of ascorbate. DNA was isolated and subjected to agarose gel electrophoresis and the size and distribution of the DNA fragments produced by the agents were compared.
Emil, Mladenov, Boyka, Anachkova
openaire   +2 more sources

Alternative method for oral administration of insoluble toxins to rats. A prenatal study of L-mimosine.

Toxicon, 2021
L-mimosine is a compound found in Leucaena leucocephala, that is used as animal feed due to its high protein content, but it can also cause intoxication.
E. R. D. de Almeida, E. C. Martinelli, E. Pereira, L. E. Raspantini, I. M. Hueza   +4 more
semanticscholar   +1 more source

Does the size of larval groups influence the effect of metabolic inhibitors on the development of Phormia regina (Diptera: Calliphoridae) larvae?

European Journal of Entomology, 2002
A series of experiments were conducted to compare the susceptibility of P. regina larvae reared in isolation or in groups to the effects of diet-borne metabolic inhibitors: chlorogenic acid (CGA) and mimosine.
Paul W.C. GREEN, Monique S.J. SIMMONDS, Wally M. BLANEY   +2 more
doaj   +1 more source