Results 11 to 20 of about 169 (131)

The identification of dual protective agents against cisplatin-induced oto- and nephrotoxicity using the zebrafish model

eLife, 2020
Dose-limiting toxicities for cisplatin administration, including ototoxicity and nephrotoxicity, impact the clinical utility of this effective chemotherapy agent and lead to lifelong complications, particularly in pediatric cancer survivors.
Jaime N Wertman, Nicole Melong, Matthew R Stoyek, Olivia Piccolo, Stewart Langley, Benno Orr, Shelby L Steele, Babak Razaghi, Jason N Berman   +8 more
doaj   +1 more source

DNA Breaks Induction by Mimosine

Zeitschrift für Naturforschung C, 2003
Abstract Mouse erythroleukemic F4 N cells were treated with mimosine, etoposide, Fe(II)-EDTA, and Cu(II) in the presence of ascorbate. DNA was isolated and subjected to agarose gel electrophoresis and the size and distribution of the DNA fragments produced by the agents were compared.
Emil, Mladenov, Boyka, Anachkova
openaire   +2 more sources

Mimosine functionalized gold nanoparticles (Mimo-AuNPs) suppress β-amyloid aggregation and neuronal toxicity

Bioactive Materials, 2021
Evidence suggests that increased level/aggregation of beta-amyloid (Aβ) peptides initiate neurodegeneration and subsequent development of Alzheimer's disease (AD). At present, there is no effective treatment for AD. In this study, we reported the effects
Bibin G. Anand, Qi Wu, Govindarajan Karthivashan, Kiran P. Shejale, Sara Amidian, Holger Wille, Satyabrata Kar   +6 more
doaj   +1 more source

EVALUATION OF MIMOSINE TOXICITY IN GOAT AND BUFFALO ERYTHROCYTE SYSTEM IN VITRO [PDF]

Exploratory Animal and Medical Research, 2012
Dose and time dependent effect of mimosine in goat and buffalo erythrocyte system in vitro have been evaluated in the present study. The results obtained exhibit that mimosine induces hemolysis in both mode of studies with concomitant increase in ...
Arun Kumar Brahmachari
doaj  

Effect of Feeding Different Cultivars of Leucaena leucocephala on Rumen-Based in vitro Anaerobic Fermentations

Proceedings, 2020
The leguminous forage shrub, Leucaena leucocephala, is one of the few nutritional options available to significantly improve beef productivity in Northern Australia.
Diane Ouwerkerk, Anita Maguire, Jenny Gravel, Cathy Minchin, Michael Gravel, Athol Klieve, Ros Gilbert   +6 more
doaj   +1 more source

Does the size of larval groups influence the effect of metabolic inhibitors on the development of Phormia regina (Diptera: Calliphoridae) larvae?

European Journal of Entomology, 2002
A series of experiments were conducted to compare the susceptibility of P. regina larvae reared in isolation or in groups to the effects of diet-borne metabolic inhibitors: chlorogenic acid (CGA) and mimosine.
Paul W.C. GREEN, Monique S.J. SIMMONDS, Wally M. BLANEY   +2 more
doaj   +1 more source

Natural Deep Eutectic Solvent based Ultrasound-assisted extraction: A green approach for extraction of sulfhydryl and mimosine from Leucaena leucocephala (Lam) de Wit seeds

Heliyon, 2023
Leucaena leucocephala (Lam.) de Wit seeds, also known as river tamarind, contain sulfhydryl compounds that exhibit antioxidant effects. However, these seeds also possess a toxic effect from mimosine. In this study, the river tamarind seeds were extracted
Islamudin Ahmad, Baso Didik Hikmawan, Disqi Fahira Maharani, Nadya Nisrina, Ayun Erwina Arifianti, Abdul Mun’im   +5 more
doaj   +1 more source

Inhibition of activity of collagen degradation in cartilage of patients with osteoarthrosis byactivation of glycolysis

Остеопороз и остеопатии, 2011
Aim. To study the effect of glycolysis activators deferrioxamine (DFO), CoCl2, V(SO4)2 and mimosine on collagen cleavage activity by collagenase in osteoarthritic (OA) articular cartilage explants. Materials and methods.
E. V. Chetina, E. V. Chetina
doaj   +1 more source

Mimosine concentration in giant leucaena (Leucaena leucocephala subsp. glabrata) fluctuates with age and plant part

Tropical Grasslands-Forrajes Tropicales
Giant leucaena is a multipurpose tree-legume found throughout the tropics and sub-tropics. Its foliage is used as animal fodder due to high protein and fiber.
Michael Honda, Dulal Borthakur
doaj   +1 more source

Investigating the role of mimosine-induced genotoxic stress through DNA repair profiling

Molecular Therapy: Nucleic Acids
Small molecules that induce DNA double-strand breaks (DSBs) are of significant interest for cancer therapy due to their ability to exploit repair vulnerabilities in tumor cells.
Sai Pallavi Pradeep, Suraj Kalaria, Peter M. Glazer, Raman Bahal   +3 more
doaj   +1 more source