Results 11 to 20 of about 3,625 (212)

Leucaena leucocephala IN RUMINANT NUTRITION [PDF]

Tropical and Subtropical Agroecosystems, 2014
It is a common situation in extensive ruminant production systems in tropical countries to have low production indicators due to nutrient deficiencies in the diet.
M. Barros-Rodríguez, C.A. Sandoval-Castro, J. Solorio-Sánchez, L. Sarmiento-Franco, R. Rojas-Herrera, A.V. Klieve   +5 more
doaj   +3 more sources

Tolerance and Excretion of Mimosine in the Fowl [PDF]

Nature, 1965
Hegarty, Schinckel and Court1 have reported the use of isolated mimosine (β-[N-(3-hydroxypyridone-4)]-α-aminopropionic acid) in metabolism investigations with sheep. They reported that the major metabolite 3,4-di-hydroxypyridine (DHP) was present in the urine, and that degradation of mimosine to DHP occurred in the rumen, the animal being unable to ...
exaly   +3 more sources

Systemic Toxicity of L-Mimosine in Rabbits: A Non-Rodent Model for Safety Assessment. [PDF]

J Appl Toxicol
ABSTRACT L‐mimosine is a non‐protein amino acid primarily found in the Mimosoideae subfamily, with high concentrations in Leucaena leucocephala and Mimosa pudica. These plants are widely used in both human and animal nutrition, as well as in phytotherapeutic applications. While the toxic effects of L‐mimosine have been extensively studied in ruminants,
Ferreira SM, Zapparoli H, Mussi CS, Maiorka PC, Andrade AFC, Górniak SL, Gotardo AT.   +6 more
europepmc   +2 more sources

A new spin on chemotaxonomy: Using non-proteogenic amino acids as a test case. [PDF]

Appl Plant Sci
Abstract Premise Specialized metabolites serve various roles for plants and humans. Unlike core metabolites, specialized metabolites are restricted to certain plant lineages; thus, in addition to their ecological functions, specialized metabolites can serve as diagnostic markers of plant lineages.
Gibson M, Thives Santos W, Oyler AR, Busta L, Schenck CA.   +4 more
europepmc   +2 more sources

Nuclear Import Defects Drive Cell Cycle Dysregulation in Neurodegeneration. [PDF]

Aging Cell
Overview of Dysregulated Cell Cycle Mechanisms in Neuronal Cells. A nuclear import block drives cell cycle re‐entry from G0, culminating in cell cycle arrest at G1/S. This cell cycle arrest is associated with activation of CKIs from the INK locus (p15, p16, p18, p19) and Cip/Kip (p21, p27) which act on specific CDK/Cyclin complexes.
Plessis-Belair J, Russo T, Riessland M, Sher RB.   +3 more
europepmc   +2 more sources

A maceration treatment of leucaena foliage improves its nutritional value by reducing mimosine concentration

Tropical Grasslands-Forrajes Tropicales, 2022
Giant leucaena produces high dry matter yields but the foliage contains mimosine, a non-protein amino acid that is toxic to animals, especially non-ruminants.
Michael D.H. Honda, Adel Youkhana, Travis Idol, Dulal Borthakur   +3 more
doaj   +1 more source

Mimosine Targets Serine Hydroxymethyltransferase [PDF]

Journal of Biological Chemistry, 1996
The plant amino acid, mimosine, is an extremely effective inhibitor of DNA replication in mammalian cells (Mosca, P. J., Dijkwel, P. A., and Hamlin, J. L. (1992) Mol. Cell. Biol. 12, 4375-4383). Mimosine appears to prevent the formation of replication forks at early-firing origins when delivered to mammalian cells approaching the G1/S boundary, and ...
H B, Lin, R, Falchetto, P J, Mosca, J, Shabanowitz, D F, Hunt, J L, Hamlin   +5 more
openaire   +2 more sources

Removal of Mimosine from Leucaena leucocephala (Lam.) de Wit Seeds to Increase Their Benefits as Nutraceuticals

Pharmaceutical Sciences and Research, 2020
The Leucaena leucocephala (Lam.) de Wit tree contains pharmacologically active compounds and can easily be found in abundant quantities. The utilization of this tree as a source of nutraceuticals would increase its value.
Sri Wardatun, Yahdiana Harahap, Abdul Mun’im, Fadlina Chany Saputri, Noorwati Sutandyo   +4 more
doaj   +1 more source

Synthesis of novel azo compounds containing 5(4H)-oxazolone ring as potent tyrosinase inhibitors [PDF]

, 2013
Six new azo dyes containing of 5(4H)-oxazolone ring were prepared by diazotization of 4-aminohippuric acid and coupling with N,N-dimethylaniline, 1-naphthol and 2-naphthol and condensation with 4-fluoro benzaldehyde or 4-trifluoromethoxy benzaldehyde ...
Abbasalipour, V., Fozooni, S., Hamidian, H., Namjou, M., Tagizadeh, R., Taheri, A.   +5 more
core   +1 more source

Identification of murine phosphodiesterase 5A isoforms and their functional characterization in HL-1 cardiac cell line [PDF]

, 2017
Phosphodiesterase 5A (PDE5A) specifically degrades the ubiquitous second messenger cGMP and experimental and clinical data highlight its important role in cardiac diseases.
Barbagallo, Federica, Campolo, Federica, Cardarelli, Silvia, Cornacchione, Marisa, DE ARCANGELIS, Valeria, DI GRAZIA, Antonio, Gianfrilli, Daniele, Giorgi, Mauro, Isidori, Andrea, Lenzi, Andrea, Monaco, Lucia, Naro, Fabio, Pellegrini, Manuela, Zevini, Alessandra   +13 more
core   +1 more source