Results 21 to 30 of about 3,625 (212)

Generation of reactive oxygen species by hydroxypyridone compound/iron complexes

open access: yesRedox Report, 2020
Objectives: Prooxidant properties of iron-binding hydroxypyridone compounds including deferiprone and mimosine were analyzed. Methods: Hydroxypyridone/iron-dependent production of reactive oxygen species was evidenced by the inactivation of aconitase ...
Keiko Murakami, Masataka Yoshino
doaj   +1 more source

Mimosine concentration in Leucaena leucocephala under various environmental conditions

open access: yesTropical Grasslands-Forrajes Tropicales, 2019
Keynote paper presented at the International Leucaena Conference, 1‒3 November 2018, Brisbane, Queensland, Australia. Leucaena leucocephala (leucaena) is a multipurpose tropical tree-legume that is highly resistant to many biotic and abiotic stresses ...
Michael D.H. Honda, Dulal Borthakur
doaj   +1 more source

Nanosecond electric pulses penetrate the nucleus and enhance speckle formation [PDF]

open access: yes, 2007
Nanosecond electric pulses generate nanopores in the interior membranes of cells and modulate cellular functions. Here, we used confocal microscopy and flow cytometry to observe Smith antigen antibody (Y12) binding to nuclear speckles, known as small ...
Beebe, S J   +9 more
core   +1 more source

Phosphorylation of MCPH1 isoforms during mitosis followed by isoform‐specific degradation by APC/C‐CDH1 [PDF]

open access: yes, 2019
Microcephalin‐1 (MCPH1) exists as 2 isoforms that regulate cyclin‐dependent kinase‐1 activation and chromosome condensation during mitosis, with MCPH1 mutations causing primary microcephaly.
Blain, Peter G.   +5 more
core   +2 more sources

The identification of dual protective agents against cisplatin-induced oto- and nephrotoxicity using the zebrafish model

open access: yeseLife, 2020
Dose-limiting toxicities for cisplatin administration, including ototoxicity and nephrotoxicity, impact the clinical utility of this effective chemotherapy agent and lead to lifelong complications, particularly in pediatric cancer survivors.
Jaime N Wertman   +8 more
doaj   +1 more source

DNA Breaks Induction by Mimosine

open access: yesZeitschrift für Naturforschung C, 2003
Abstract Mouse erythroleukemic F4 N cells were treated with mimosine, etoposide, Fe(II)-EDTA, and Cu(II) in the presence of ascorbate. DNA was isolated and subjected to agarose gel electrophoresis and the size and distribution of the DNA fragments produced by the agents were compared.
Emil, Mladenov, Boyka, Anachkova
openaire   +2 more sources

EVALUATION OF MIMOSINE TOXICITY IN GOAT AND BUFFALO ERYTHROCYTE SYSTEM IN VITRO [PDF]

open access: yesExploratory Animal and Medical Research, 2012
Dose and time dependent effect of mimosine in goat and buffalo erythrocyte system in vitro have been evaluated in the present study. The results obtained exhibit that mimosine induces hemolysis in both mode of studies with concomitant increase in ...
Arun Kumar Brahmachari
doaj  

Mimosine functionalized gold nanoparticles (Mimo-AuNPs) suppress β-amyloid aggregation and neuronal toxicity

open access: yesBioactive Materials, 2021
Evidence suggests that increased level/aggregation of beta-amyloid (Aβ) peptides initiate neurodegeneration and subsequent development of Alzheimer's disease (AD). At present, there is no effective treatment for AD. In this study, we reported the effects
Bibin G. Anand   +6 more
doaj   +1 more source

Effect of Feeding Different Cultivars of Leucaena leucocephala on Rumen-Based in vitro Anaerobic Fermentations

open access: yesProceedings, 2020
The leguminous forage shrub, Leucaena leucocephala, is one of the few nutritional options available to significantly improve beef productivity in Northern Australia.
Diane Ouwerkerk   +6 more
doaj   +1 more source

DDK dependent regulation of TOP2A at centromeres revealed by a chemical genetics approach [PDF]

open access: yes, 2016
In eukaryotic cells the CDC7/DBF4 kinase, also known as DBF4-dependent kinase (DDK), is required for the firing of DNA replication origins. CDC7 is also involved in replication stress responses and its depletion sensitises cells to drugs that affect fork
Bachi, Angela   +7 more
core   +2 more sources

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